Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1502186090', 'doi': 'https://doi.org/10.18632/oncotarget.3959', 'title': 'EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy', 'display_name': 'EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy', 'publication_year': 2015, 'publication_date': '2015-04-29', 'ids': {'openalex': 'https://openalex.org/W1502186090', 'doi': 'https://doi.org/10.18632/oncotarget.3959', 'mag': '1502186090', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26036637', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4627323'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3959', 'pdf_url': 'https://www.oncotarget.com/article/3959/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3959/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008769133', 'display_name': 'Yun-Tian Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yun-Tian Li', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103343374', 'display_name': 'Xiao-Jun Qian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}, {'id': 'https://openalex.org/I4210129412', 'display_name': 'Anhui Provincial Hospital', 'ror': 'https://ror.org/03n5gdd09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129412']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Jun Qian', 'raw_affiliation_strings': ['Department of Oncology, Anhui Provincial Hospital, Affiliated to Anhui Medical University, Hefei, China', 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Anhui Provincial Hospital, Affiliated to Anhui Medical University, Hefei, China', 'institution_ids': ['https://openalex.org/I197869895', 'https://openalex.org/I4210129412']}, {'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103264433', 'display_name': 'Yan Yu', 'orcid': 'https://orcid.org/0000-0001-5598-763X'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Yu', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100357917', 'display_name': 'Zhenhua Li', 'orcid': 'https://orcid.org/0000-0001-6188-9454'}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhen-Hua Li', 'raw_affiliation_strings': ['The School of Medicine, Jinan University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'The School of Medicine, Jinan University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100810052', 'display_name': 'Rui-Yan Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rui-Yan Wu', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100991166', 'display_name': 'Jiao Ji', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiao Ji', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101728615', 'display_name': 'Lin Jiao', 'orcid': 'https://orcid.org/0000-0001-5861-2585'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin Jiao', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100362252', 'display_name': 'Xuan Li', 'orcid': 'https://orcid.org/0000-0001-5744-5818'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xuan Li', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103052467', 'display_name': 'Pengfei Kong', 'orcid': 'https://orcid.org/0000-0001-5864-4317'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Peng-Fei Kong', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034200339', 'display_name': 'Wen-Dan Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen-Dan Chen', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100836048', 'display_name': 'Gong-Kan Feng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gong-Kan Feng', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041146217', 'display_name': 'Rong Deng', 'orcid': 'https://orcid.org/0000-0003-3724-0326'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rong Deng', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101587495', 'display_name': 'Xiao‐Feng Zhu', 'orcid': 'https://orcid.org/0000-0002-1313-4783'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Feng Zhu', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-Sen University, Guangzhou, China.', 'institution_ids': ['https://openalex.org/I157773358']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.885, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.602727, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '6', 'issue': '19', 'first_page': '17491', 'last_page': '17500'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11535', 'display_name': 'Chemotherapy-induced cardiotoxicity and mitigation', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lapatinib', 'display_name': 'Lapatinib', 'score': 0.4915062}, {'id': 'https://openalex.org/keywords/egfr-inhibitors', 'display_name': 'EGFR Inhibitors', 'score': 0.45511088}], 'concepts': [{'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.80145836}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.6442441}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.5896596}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.56019485}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5300486}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.5038523}, {'id': 'https://openalex.org/C2777329042', 'wikidata': 'https://www.wikidata.org/wiki/Q420323', 'display_name': 'Lapatinib', 'level': 5, 'score': 0.4915062}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.4768418}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.45575494}, {'id': 'https://openalex.org/C2777506169', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'EGFR inhibitors', 'level': 4, 'score': 0.45511088}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.45364308}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.43115985}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.43050763}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41801023}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.31686574}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.31112552}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30854008}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1664517}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.16015118}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.14342886}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.08222309}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.06159264}, {'id': 'https://openalex.org/C2779786085', 'wikidata': 'https://www.wikidata.org/wiki/Q412616', 'display_name': 'Trastuzumab', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053181', 'descriptor_name': 'Caspase 8', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D055503', 'descriptor_name': 'Protein Multimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053181', 'descriptor_name': 'Caspase 8', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D000069347', 'descriptor_name': 'Erlotinib Hydrochloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069347', 'descriptor_name': 'Erlotinib Hydrochloride', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077341', 'descriptor_name': 'Lapatinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3959', 'pdf_url': 'https://www.oncotarget.com/article/3959/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4627323', 'pdf_url': 'https://europepmc.org/articles/pmc4627323?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627323', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26036637', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3959', 'pdf_url': 'https://www.oncotarget.com/article/3959/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.71, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1525771749', 'https://openalex.org/W1543790510', 'https://openalex.org/W161836838', 'https://openalex.org/W181281151', 'https://openalex.org/W1922109732', 'https://openalex.org/W1966106271', 'https://openalex.org/W1966176339', 'https://openalex.org/W1974091059', 'https://openalex.org/W1998887711', 'https://openalex.org/W2000800162', 'https://openalex.org/W2002408013', 'https://openalex.org/W2013993442', 'https://openalex.org/W2017322442', 'https://openalex.org/W2042280375', 'https://openalex.org/W2048428832', 'https://openalex.org/W2050573392', 'https://openalex.org/W2061061337', 'https://openalex.org/W2061620817', 'https://openalex.org/W2089082314', 'https://openalex.org/W2106926141', 'https://openalex.org/W2114865501', 'https://openalex.org/W2116827288', 'https://openalex.org/W2123183032', 'https://openalex.org/W2127101185', 'https://openalex.org/W2138095640', 'https://openalex.org/W2139552156', 'https://openalex.org/W2140860403', 'https://openalex.org/W2144169031', 'https://openalex.org/W2151457918', 'https://openalex.org/W2151967230', 'https://openalex.org/W2152595793', 'https://openalex.org/W2152755651', 'https://openalex.org/W2153769134', 'https://openalex.org/W2409064332', 'https://openalex.org/W4233039589'], 'related_works': ['https://openalex.org/W4385483651', 'https://openalex.org/W4224986373', 'https://openalex.org/W2418580632', 'https://openalex.org/W2391963389', 'https://openalex.org/W2363922458', 'https://openalex.org/W2150377676', 'https://openalex.org/W2110887292', 'https://openalex.org/W2091157550', 'https://openalex.org/W2075966869', 'https://openalex.org/W2048136894'], 'abstract_inverted_index': {'//': [0, 111], 'Yun-Tian': [1], 'Li': [2, 14, 30], '1,*': [3, 11], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44], 'Xiao-Jun': [5], 'Qian': [6], '1,2,*': [7], 'Yan': [9], 'Yu': [10], 'Zhen-Hua': [13], '3': [15, 88], 'Rui-Yan': [17], 'Wu': [18], '1': [19, 23, 27, 31, 35, 39, 43, 47, 51, 52], 'Jiao': [21, 26], 'Ji': [22], 'Lin': [25], 'Xuan': [29], 'Peng-Fei': [33], 'Kong': [34], 'Wen-Dan': [37], 'Chen': [38], 'Gong-Kan': [41], 'Feng': [42], 'Rong': [45], 'Deng': [46], 'and': [48, 142, 170, 200, 207, 216, 292, 301], 'Xiao-Feng': [49, 108], 'Zhu': [50], 'State': [53], 'Key': [54], 'Laboratory': [55], 'of': [56, 76, 91, 140, 168, 190, 196, 205, 252, 264, 289, 299], 'Oncology': [57], 'in': [58, 150], 'South': [59], 'China,': [60], 'Collaborative': [61], 'Innovation': [62], 'Center': [63], 'for': [64, 283, 286], 'Cancer': [65, 67], 'Medicine,': [66, 92], 'Center,': [68], 'Sun': [69], 'Yat-sen': [70], 'University,': [71, 85, 94], 'Guangzhou,': [72, 95], 'China': [73, 87, 96], '2': [74], 'Department': [75], 'Oncology,': [77], 'Anhui': [78, 83], 'Provincial': [79], 'Hospital,': [80], 'Affiliated': [81], 'to': [82, 103, 194, 248, 276], 'Medical': [84], 'Hefei,': [86], 'The': [89, 138], 'School': [90], 'Jinan': [93], '*': [97], 'These': [98], 'authors': [99], 'have': [100], 'contributed': [101], 'equally': [102], 'this': [104], 'work': [105], 'Correspondence': [106], 'to:': [107], 'Zhu,': [109], 'email:': [110], 'Keywords': [112], ':': [113, 123, 128, 133], 'EGFR': [114, 198, 226, 265], 'inhibitors,': [115], 'doxorubicin,': [116], 'breast': [117], 'cancer,': [118], 'caspase-8,': [119], 'sequential': [120], 'application': [121, 204], 'Received': [122], 'February': [124], '11,': [125], '2015': [126, 131, 136], 'Accepted': [127], 'April': [129, 134], '09,': [130], 'Published': [132], '29,': [135], 'Abstract': [137], 'combination': [139], 'time': [141, 300], 'order-dependent': [143, 302], 'chemotherapeutic': [144], 'strategies': [145, 285], 'has': [146, 245], 'demonstrated': [147], 'enhanced': [148, 186], 'efficacy': [149], 'killing': [151], 'cancer': [152, 274], 'cells': [153, 172, 275], 'while': [154, 236], 'minimizing': [155], 'adverse': [156], 'effects.': [157], 'However,': [158], 'the': [159, 187, 197, 246, 250, 262, 287], 'precise': [160], 'mechanism': [161], 'remains elusive.': [162], 'Our': [163, 240, 279], 'results': [164], 'showed': [165], 'that': [166, 225, 243, 272], 'pre-treatment': [167], 'MCF-7': [169], 'MDA-MB-468': [171], 'with': [173], 'epidermal': [174], 'growth': [175], 'factor': [176], 'receptor': [177], '(EGFR)': [178], 'tyrosine': [179, 266], 'kinase': [180, 267], 'inhibitor': [181, 199], 'erlotinib': [182, 206], 'or': [183], 'lapatinib': [184], 'significantly': [185], 'cytotoxic': [188, 293], 'effects': [189], 'DNA-damaging': [191, 201, 277], 'agents': [192], 'compared': [193], 'coadministration': [195, 220], 'agent.': [202], 'Sequential': [203], 'doxorubicin': [208, 237], 'increased': [209], 'activated': [210], 'caspase-8': [211], 'by': [212, 231, 255], 'promoting': [213], 'pro-caspase-8': [214, 229, 253, 257, 270], 'homodimerization': [215, 230], 'autocatalytical': [217], 'cleavage,': [218], 'whereas': [219], 'did': [221], 'not.': [222], 'We': [223], 'found': [224], 'inhibitors': [227, 268], 'promoted': [228, 238], 'inhibiting': [232], 'ERK': [233, 244], 'pathway': [234], 'signaling,': [235], 'it.': [239], 'data': [241], 'highlight': [242], 'potential': [247], 'inhibit': [249], 'formation': [251], 'homodimers': [254], 'phosphorylating': [256], 'at': [258], 'S387.': [259], 'In': [260], 'conclusion,': [261], 'pretreatment': [263], 'promote': [269], 'dimerization': [271], 'sensitizes': [273], 'agents.': [278], 'findings': [280], 'provide': [281], 'rationale': [282], 'novel': [284], 'implementation': [288], 'combined': [290], 'targeted': [291], 'chemotherapy': [294], 'within': [295], 'a': [296], 'new': [297], 'framework': [298], 'therapy.': [303]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1502186090', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-12-09T09:41:01.166465', 'created_date': '2016-06-24'}