Title: Diagnostics of autoimmune bullous diseases in German dermatology departments
Abstract: JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 10, Issue 7 p. 492-499 Diagnostics of autoimmune bullous diseases in German dermatology departments Nina van Beek, Nina van Beek Department of Dermatology, Allergology and Venereology, University of LübeckSearch for more papers by this authorDiana Knuth- Rehr, Diana Knuth- Rehr Institute for Systemic Inflammation Research, University of LübeckSearch for more papers by this authorPeter Altmeyer, Peter Altmeyer Department of Dermatology and Allergology, University of BochumSearch for more papers by this authorChalid Assaf, Chalid Assaf Dermatology Clinic, HELIOS Clinic, KrefeldSearch for more papers by this authorPhilipp Babilas, Philipp Babilas Department of Dermatology, University of RegensburgSearch for more papers by this authorChristiane Bayerl, Christiane Bayerl Department of Dermatology and Allergology, Dr.Horst Schmidt Clinics, WiesbadenSearch for more papers by this authorSandrine Benoit, Sandrine Benoit Department of Dermatology, Venereology and Allergology, University of WürzburgSearch for more papers by this authorEdgar Dippel, Edgar Dippel Dermatology Clinic LudwigshafenSearch for more papers by this authorIsaak Effendy, Isaak Effendy Department of Dermatology, Municipal Clinic of BielefeldSearch for more papers by this authorRüdiger Eming, Rüdiger Eming Department of Dermatology, University of MarburgSearch for more papers by this authorMatthias Fischer, Matthias Fischer Department of Dermatology and Venereology, HELIOS Clinic AueSearch for more papers by this authorThomas Glaenz, Thomas Glaenz PsoriSol Dermatology Clinic, HersbruckSearch for more papers by this authorRegine Gläser, Regine Gläser Department of Dermatology, Allergology and Venereology, University of KielSearch for more papers by this authorMatthias Goebeler, Matthias Goebeler Department for Dermatology, Venereology and Allergology, University of GießenSearch for more papers by this authorHarald Gollnick, Harald Gollnick Department of Dermatology and Venereology, University of MagdeburgSearch for more papers by this authorSteven Götze, Steven Götze Department of Dermatology and Allergology, University of JenaSearch for more papers by this authorGerd Gross, Gerd Gross Department of Dermatology and Venereology, University of RostockSearch for more papers by this authorEva Hadaschik, Eva Hadaschik Department of Dermatology, University of HeidelbergSearch for more papers by this authorRudolf Herbst, Rudolf Herbst Department of Dermatology and Allergolgoy, HELIOS Clinic ErfurtSearch for more papers by this authorBarbara Hermes, Barbara Hermes Department of Dermatology and Phlebology, Vivantes Clinic Friedrichshain, BerlinSearch for more papers by this authorBernhard Homey, Bernhard Homey Department of Dermatology, University of DüsseldorfSearch for more papers by this authorNico Hunzelmann, Nico Hunzelmann Department of Dermatology and Venereology, University of KölnSearch for more papers by this authorMichael Jünger, Michael Jünger Department of Dermatology, University of GreifswaldSearch for more papers by this authorAlexander Kapp, Alexander Kapp Department of Dermatology, Allergology and Venerology, Hannover Medical SchoolSearch for more papers by this authorJohannes S. Kern, Johannes S. Kern Department of Dermatology, University of FreiburgSearch for more papers by this authorAndreas Körber, Andreas Körber Department of Dermatology, University of EssenSearch for more papers by this authorThomas Luger, Thomas Luger Department of Dermatology, University of MünsterSearch for more papers by this authorDirk Mechtel, Dirk Mechtel Department of Dermatology and Allergology, Heinrich Braun Clinic ZwickauSearch for more papers by this authorMosaad Megahed, Mosaad Megahed Department of Dermatology, University of AachenSearch for more papers by this authorIngrid Moll, Ingrid Moll Department of Dermatology and Venereology, University Clinic of Eppendorf, HamburgSearch for more papers by this authorKlaus-Peter Peters, Klaus-Peter Peters Department of Dermatology, Bayreuth Hospital, BayreuthSearch for more papers by this authorChristiane Pfeiffer, Christiane Pfeiffer Department of Dermatology and Alergology, University of UlmSearch for more papers by this authorJohannes Ring, Johannes Ring Department of Dermatology and Allergology, Technical University of MunichSearch for more papers by this authorMartin Röcken, Martin Röcken Department of Dermatology, University of TübingenSearch for more papers by this authorMiklós Sárdy, Miklós Sárdy Department of Dermatology and Allergology, Ludwig Maximilian University of MunichSearch for more papers by this authorCornelia S. Seitz, Cornelia S. Seitz Department of Dermatology, Venereology and Allergology, University of GöttingenSearch for more papers by this authorRudolf Stadler, Rudolf Stadler Department of Dermatology, Johannes Wesling Clinic, MindenSearch for more papers by this authorKerstin Steinbrink, Kerstin Steinbrink Department of Dermatology, University of MainzSearch for more papers by this authorMichael Sticherling, Michael Sticherling Department of Dermatology, University of ErlangenSearch for more papers by this authorRolf-Markus Szeimies, Rolf-Markus Szeimies Department of Dermatology and Allergology, Vest Clinic-Miners' Hospital, RecklinghausenSearch for more papers by this authorMichael Tronnier, Michael Tronnier Department of Dermatology, Venereology and Allergology, Hildesheim Clinic, HildesheimSearch for more papers by this authorJens Ulrich, Jens Ulrich Department of Dermatology and Allerogology, Erxleben Clinic, QuedlinburgSearch for more papers by this authorThomas Vogt, Thomas Vogt Department of Dermatology, Venereology and Allergology, University of the Saarland, Homburg/SaarSearch for more papers by this authorNicola Wagner, Nicola Wagner Department of Dermatology, Darmstadt Hospital, DarmstadtSearch for more papers by this authorJulia Welzel, Julia Welzel Department of Dermatology, Augsburg Hospital, AugsburgSearch for more papers by this authorJörg Wenzel, Jörg Wenzel Department of Dermatology and Allergology, University of BonnSearch for more papers by this authorGottfried Wozel, Gottfried Wozel Department of Dermatology, University of DresdenSearch for more papers by this authorChristos C. Zouboulis, Christos C. Zouboulis Department of Dermatology, Venereology and Allergology/ Immunological Center, Municipal Clinic of Dessau (all Germany)Search for more papers by this authorDetlef Zillikens, Detlef Zillikens Department of Dermatology, Allergology and Venereology, University of LübeckSearch for more papers by this authorEnno Schmidt, Enno Schmidt Department of Dermatology, Allergology and Venereology, University of Lübeck Institute for Systemic Inflammation Research, University of LübeckSearch for more papers by this author Nina van Beek, Nina van Beek Department of Dermatology, Allergology and Venereology, University of LübeckSearch for more papers by this authorDiana Knuth- Rehr, Diana Knuth- Rehr Institute for Systemic Inflammation Research, University of LübeckSearch for more papers by this authorPeter Altmeyer, Peter Altmeyer Department of Dermatology and Allergology, University of BochumSearch for more papers by this authorChalid Assaf, Chalid Assaf Dermatology Clinic, HELIOS Clinic, KrefeldSearch for more papers by this authorPhilipp Babilas, Philipp Babilas Department of Dermatology, University of RegensburgSearch for more papers by this authorChristiane Bayerl, Christiane Bayerl Department of Dermatology and Allergology, Dr.Horst Schmidt Clinics, WiesbadenSearch for more papers by this authorSandrine Benoit, Sandrine Benoit Department of Dermatology, Venereology and Allergology, University of WürzburgSearch for more papers by this authorEdgar Dippel, Edgar Dippel Dermatology Clinic LudwigshafenSearch for more papers by this authorIsaak Effendy, Isaak Effendy Department of Dermatology, Municipal Clinic of BielefeldSearch for more papers by this authorRüdiger Eming, Rüdiger Eming Department of Dermatology, University of MarburgSearch for more papers by this authorMatthias Fischer, Matthias Fischer Department of Dermatology and Venereology, HELIOS Clinic AueSearch for more papers by this authorThomas Glaenz, Thomas Glaenz PsoriSol Dermatology Clinic, HersbruckSearch for more papers by this authorRegine Gläser, Regine Gläser Department of Dermatology, Allergology and Venereology, University of KielSearch for more papers by this authorMatthias Goebeler, Matthias Goebeler Department for Dermatology, Venereology and Allergology, University of GießenSearch for more papers by this authorHarald Gollnick, Harald Gollnick Department of Dermatology and Venereology, University of MagdeburgSearch for more papers by this authorSteven Götze, Steven Götze Department of Dermatology and Allergology, University of JenaSearch for more papers by this authorGerd Gross, Gerd Gross Department of Dermatology and Venereology, University of RostockSearch for more papers by this authorEva Hadaschik, Eva Hadaschik Department of Dermatology, University of HeidelbergSearch for more papers by this authorRudolf Herbst, Rudolf Herbst Department of Dermatology and Allergolgoy, HELIOS Clinic ErfurtSearch for more papers by this authorBarbara Hermes, Barbara Hermes Department of Dermatology and Phlebology, Vivantes Clinic Friedrichshain, BerlinSearch for more papers by this authorBernhard Homey, Bernhard Homey Department of Dermatology, University of DüsseldorfSearch for more papers by this authorNico Hunzelmann, Nico Hunzelmann Department of Dermatology and Venereology, University of KölnSearch for more papers by this authorMichael Jünger, Michael Jünger Department of Dermatology, University of GreifswaldSearch for more papers by this authorAlexander Kapp, Alexander Kapp Department of Dermatology, Allergology and Venerology, Hannover Medical SchoolSearch for more papers by this authorJohannes S. Kern, Johannes S. Kern Department of Dermatology, University of FreiburgSearch for more papers by this authorAndreas Körber, Andreas Körber Department of Dermatology, University of EssenSearch for more papers by this authorThomas Luger, Thomas Luger Department of Dermatology, University of MünsterSearch for more papers by this authorDirk Mechtel, Dirk Mechtel Department of Dermatology and Allergology, Heinrich Braun Clinic ZwickauSearch for more papers by this authorMosaad Megahed, Mosaad Megahed Department of Dermatology, University of AachenSearch for more papers by this authorIngrid Moll, Ingrid Moll Department of Dermatology and Venereology, University Clinic of Eppendorf, HamburgSearch for more papers by this authorKlaus-Peter Peters, Klaus-Peter Peters Department of Dermatology, Bayreuth Hospital, BayreuthSearch for more papers by this authorChristiane Pfeiffer, Christiane Pfeiffer Department of Dermatology and Alergology, University of UlmSearch for more papers by this authorJohannes Ring, Johannes Ring Department of Dermatology and Allergology, Technical University of MunichSearch for more papers by this authorMartin Röcken, Martin Röcken Department of Dermatology, University of TübingenSearch for more papers by this authorMiklós Sárdy, Miklós Sárdy Department of Dermatology and Allergology, Ludwig Maximilian University of MunichSearch for more papers by this authorCornelia S. Seitz, Cornelia S. Seitz Department of Dermatology, Venereology and Allergology, University of GöttingenSearch for more papers by this authorRudolf Stadler, Rudolf Stadler Department of Dermatology, Johannes Wesling Clinic, MindenSearch for more papers by this authorKerstin Steinbrink, Kerstin Steinbrink Department of Dermatology, University of MainzSearch for more papers by this authorMichael Sticherling, Michael Sticherling Department of Dermatology, University of ErlangenSearch for more papers by this authorRolf-Markus Szeimies, Rolf-Markus Szeimies Department of Dermatology and Allergology, Vest Clinic-Miners' Hospital, RecklinghausenSearch for more papers by this authorMichael Tronnier, Michael Tronnier Department of Dermatology, Venereology and Allergology, Hildesheim Clinic, HildesheimSearch for more papers by this authorJens Ulrich, Jens Ulrich Department of Dermatology and Allerogology, Erxleben Clinic, QuedlinburgSearch for more papers by this authorThomas Vogt, Thomas Vogt Department of Dermatology, Venereology and Allergology, University of the Saarland, Homburg/SaarSearch for more papers by this authorNicola Wagner, Nicola Wagner Department of Dermatology, Darmstadt Hospital, DarmstadtSearch for more papers by this authorJulia Welzel, Julia Welzel Department of Dermatology, Augsburg Hospital, AugsburgSearch for more papers by this authorJörg Wenzel, Jörg Wenzel Department of Dermatology and Allergology, University of BonnSearch for more papers by this authorGottfried Wozel, Gottfried Wozel Department of Dermatology, University of DresdenSearch for more papers by this authorChristos C. Zouboulis, Christos C. Zouboulis Department of Dermatology, Venereology and Allergology/ Immunological Center, Municipal Clinic of Dessau (all Germany)Search for more papers by this authorDetlef Zillikens, Detlef Zillikens Department of Dermatology, Allergology and Venereology, University of LübeckSearch for more papers by this authorEnno Schmidt, Enno Schmidt Department of Dermatology, Allergology and Venereology, University of Lübeck Institute for Systemic Inflammation Research, University of LübeckSearch for more papers by this author First published: 03 February 2012 https://doi.org/10.1111/j.1610-0387.2011.07840.xCitations: 16 Prof. Enno Schmidt, MD, PhD Department of Dermatology University of Lübeck Ratzeburger Allee 160 D-23538 Lübeck, GermanyTel.: +49–451-500—2538Fax: +49–451-500—2981E-mail: [email protected] With the exception of the first two and last authors in alphabetical order. Data were summarized (< 120 words) in [ 37]. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary Background: No consistent data are available on the currently employed diagnostic tools for autoimmune bullous diseases in Germany. The aim of this survey was to describe currently performed diagnostic methods for bullous autoimmune diseases in German dermatology departments. Methods: A standardized questionnaire evaluated the available diagnostic methods i. e. direct immunofluorescence microscopy (IFM), indirect IFM, commercial ELISA systems, and non-commercial serological tests as well as the number of samples per year in all 34 university and 39 non-university dermatology departments. Results: The overall return rate was 89 %, 100 % and 79 % for the university and non-university departments, respectively. Direct IFM was the most frequently used method and was applied in 98 % of the responding departments. In 74 % of the responding departments, indirect IFM was used mainly on monkey esophagus and human salt-split skin. Commercial ELISA systems were employed in 58 % of the clinics; all of them used anti-desmoglein ELISA, while anti-BP180 and anti-BP230 ELISA were established in 49 % and 48 % of departments, respectively. Non-commercial analytic methods were only performed in 22 % of the departments. Conclusions: The high return rate of this survey allows a relatively precise description of the current diagnostic methods used in German dermatology departments. Standard diagnostic tests are available nationwide and in bullous pemphigoid and pemphigus, the antigen-specific detection of autoantibodies is routinely performed in half of the departments. Rare disorders may be diagnosed by cooperation with some specialized centers. References 1 Bertram F, Bröcker EB, Zillikens D, Schmidt E. Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany. J Dtsch Dermatol Ges 2009; 7(5): 434–40. 10.1111/j.1610-0387.2008.06976.x CASPubMedWeb of Science®Google Scholar 2 Hahn-Ristic K, Rzany B, Amagai M, Bröcker EB, Zillikens D. Increased incidence of pemphigus vulgaris in southern Europeans living in Germany compared with native Germans. 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