Abstract:This chapter discusses different types of censoring. It provides some background regarding the survival function and the use of the Kaplan—Meier method for estimation of proportions based on censored ...This chapter discusses different types of censoring. It provides some background regarding the survival function and the use of the Kaplan—Meier method for estimation of proportions based on censored data. The logrank statistic and Gehan's generalization of Wilcoxon rank sum statistic for the censored data are outlined. The chapter describes the semiparametric proportional hazard model with covariates as proposed by Cox. The concepts of calendar and information time are illustrated. The chapter covers different methods for interim analysis. These methods include the group sequential methods proposed by Pocock and O'Brien and Fleming, repeated confidence intervals suggested by Jennison and Turnbull, the method of alpha spending function by DeMets and Lan, and B-values by Lan and Wittes. Whenever possible, numerical examples using published data from real trials are used to illustrate the methods presented in the chapter. Controlled Vocabulary Terms Censoring; Kaplan-Meier estimator; proportional hazards models; sequential analysis; survival function; Wilcoxon-Mann-Whitney TestRead More
Publication Year: 2013
Publication Date: 2013-10-30
Language: en
Type: other
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot