Title: Chapter 31. Genetically modified crops as a source for pharmaceuticals
Abstract: This chapter presents an overview of genetically modified crops as a source for pharmaceuticals. The use of plants as bioreactors for recombinant protein production was made possible through the development of genetic engineering technologies and plant transformation procedures that allow introduction of foreign genes, which are stably expressed and transmissible through generations into plant cells. This concept is based on the capability to generate transformed cells that are able to regenerate into plants. The potential of transgenic plants to function as efficient bioreactors for production of recombinant proteins has generated enthusiasm for this alternative production system. Today, several human proteins are produced in transgenic crops. The focus is on pharmaceuticals produced in transgenic plants. The impact of the plant system on the development of new pharmaceuticals is discussed and production in tobacco-based expression system is elaborated. Some examples of pharmaceutical proteins produced in the tobacco plant system are presented and other recombinant protein production systems are elaborated. Development status for pharmaceuticals produced in plants is described.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 2
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