Publication Information

{'id': 'https://openalex.org/W1488314371', 'doi': 'https://doi.org/10.7175/fe.v3i3.754', 'title': 'Il trattamento di pazienti con sepsi grave mediante drotrecogin alfa: una valutazione economica con riferimento all’Italia', 'display_name': 'Il trattamento di pazienti con sepsi grave mediante drotrecogin alfa: una valutazione economica con riferimento all’Italia', 'publication_year': 2002, 'publication_date': '2002-09-15', 'ids': {'openalex': 'https://openalex.org/W1488314371', 'doi': 'https://doi.org/10.7175/fe.v3i3.754', 'mag': '1488314371'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7175/fe.v3i3.754', 'pdf_url': 'http://journals.seedmedicalpublishers.com/index.php/FE/article/download/754/852', 'source': {'id': 'https://openalex.org/S2764479002', 'display_name': 'Farmeconomia Health economics and therapeutic pathways', 'issn_l': '1721-6915', 'issn': ['1721-6915', '1721-6923', '2240-256X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317588', 'host_organization_name': 'SEEd Medical Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317588'], 'host_organization_lineage_names': ['SEEd Medical Publishers'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://journals.seedmedicalpublishers.com/index.php/FE/article/download/754/852', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006429617', 'display_name': 'Carlo Lucioni', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Carlo Lucioni', 'raw_affiliation_strings': ['ADIS International/Health Economics, Milano'], 'affiliations': [{'raw_affiliation_string': 'ADIS International/Health Economics, Milano', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108371468', 'display_name': 'S. Mazzi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Silvio Mazzi', 'raw_affiliation_strings': ['ADIS International/Health Economics, Milano'], 'affiliations': [{'raw_affiliation_string': 'ADIS International/Health Economics, Milano', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074973896', 'display_name': 'C Chinn', 'orcid': None}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Chinn Christopher', 'raw_affiliation_strings': ['Ely Lilly UK'], 'affiliations': [{'raw_affiliation_string': 'Ely Lilly UK', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1485, 'currency': 'EUR', 'value_usd': 1601, 'provenance': 'doaj'}, 'apc_paid': {'value': 1485, 'currency': 'EUR', 'value_usd': 1601, 'provenance': 'doaj'}, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.489174, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 71}, 'biblio': {'volume': '3', 'issue': '3', 'first_page': '171', 'last_page': '177'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10218', 'display_name': 'Sepsis Diagnosis and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10218', 'display_name': 'Sepsis Diagnosis and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11961', 'display_name': 'Neonatal and Maternal Infections', 'score': 0.9696, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10867', 'display_name': 'Intensive Care Unit Cognitive Disorders', 'score': 0.9492, 'subfield': {'id': 'https://openalex.org/subfields/2706', 'display_name': 'Critical Care and Intensive Care Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/drotrecogin-alfa', 'display_name': 'Drotrecogin alfa', 'score': 0.99355197}], 'concepts': [{'id': 'https://openalex.org/C2778005785', 'wikidata': 'https://www.wikidata.org/wiki/Q412888', 'display_name': 'Drotrecogin alfa', 'level': 5, 'score': 0.99355197}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.90823513}, {'id': 'https://openalex.org/C2778384902', 'wikidata': 'https://www.wikidata.org/wiki/Q183134', 'display_name': 'Sepsis', 'level': 2, 'score': 0.7192725}, {'id': 'https://openalex.org/C2781287897', 'wikidata': 'https://www.wikidata.org/wiki/Q412810', 'display_name': 'Protein C', 'level': 2, 'score': 0.5319745}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.52045035}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.45553565}, {'id': 'https://openalex.org/C2777628635', 'wikidata': 'https://www.wikidata.org/wiki/Q1765564', 'display_name': 'Septic shock', 'level': 3, 'score': 0.3975832}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.31652853}, {'id': 'https://openalex.org/C2994086866', 'wikidata': 'https://www.wikidata.org/wiki/Q183134', 'display_name': 'Severe sepsis', 'level': 4, 'score': 0.2327978}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.7175/fe.v3i3.754', 'pdf_url': 'http://journals.seedmedicalpublishers.com/index.php/FE/article/download/754/852', 'source': {'id': 'https://openalex.org/S2764479002', 'display_name': 'Farmeconomia Health economics and therapeutic pathways', 'issn_l': '1721-6915', 'issn': ['1721-6915', '1721-6923', '2240-256X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317588', 'host_organization_name': 'SEEd Medical Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317588'], 'host_organization_lineage_names': ['SEEd Medical Publishers'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/09a7ae3f8b4d4218bf684e91a008c344', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7175/fe.v3i3.754', 'pdf_url': 'http://journals.seedmedicalpublishers.com/index.php/FE/article/download/754/852', 'source': {'id': 'https://openalex.org/S2764479002', 'display_name': 'Farmeconomia Health economics and therapeutic pathways', 'issn_l': '1721-6915', 'issn': ['1721-6915', '1721-6923', '2240-256X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317588', 'host_organization_name': 'SEEd Medical Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317588'], 'host_organization_lineage_names': ['SEEd Medical Publishers'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.73}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1588026902', 'https://openalex.org/W1964007673', 'https://openalex.org/W2015414378', 'https://openalex.org/W2017401577', 'https://openalex.org/W2041987555', 'https://openalex.org/W2071686284', 'https://openalex.org/W2074503728', 'https://openalex.org/W207879614', 'https://openalex.org/W2322121630', 'https://openalex.org/W2417718136', 'https://openalex.org/W4236420392', 'https://openalex.org/W4236624503'], 'related_works': ['https://openalex.org/W4301131473', 'https://openalex.org/W2574447609', 'https://openalex.org/W2410461217', 'https://openalex.org/W2353762539', 'https://openalex.org/W2344808345', 'https://openalex.org/W2093800984', 'https://openalex.org/W2071300566', 'https://openalex.org/W2062073860', 'https://openalex.org/W2037114949', 'https://openalex.org/W2015805780'], 'abstract_inverted_index': {'Sepsis': [0], 'can': [1], 'be': [2], 'defined': [3], 'as': [4, 195], 'a': [5, 16, 39, 82, 139], 'spectrum': [6], 'of': [7, 15, 42, 60, 109, 113, 121, 131, 146, 180], 'clinical': [8], 'conditions': [9], 'caused': [10], 'by': [11, 24], 'the': [12, 53, 57, 107, 122, 128, 132, 144, 147, 156, 163, 176, 191, 198], 'immune': [13], 'response': [14], 'host': [17], 'to': [18, 126, 138, 155, 162], 'infection': [19], 'or': [20, 68], 'trauma': [21], 'and': [22, 27, 33, 44, 77, 111, 168], 'characterized': [23], 'systemic': [25], 'inflammation': [26], 'coagulation.': [28], 'Particularly': [29], 'in': [30, 46, 62, 81, 93, 183, 197], 'elderly,': [31], 'immunocompromised': [32], 'critically': [34], 'ill': [35], 'patients,': [36], 'sepsis': [37, 55, 95, 115, 185], 'is': [38, 56, 125, 187], 'major': [40], 'cause': [41, 59], 'morbidity': [43], 'mortality': [45, 92], 'intensive': [47], 'care': [48], 'units': [49], '(ICUs)': [50], 'worldwide.': [51], 'In': [52, 100], 'US,': [54], 'leading': [58], 'death': [61], 'noncoronary': [63], 'ICU': [64], 'patients.': [65], 'Drotrecogin': [66, 87, 135], 'alfa,': [67, 136], 'recombinant': [69], 'human': [70], 'activated': [71], 'protein': [72], 'C,': [73], 'has': [74, 152], 'antithrombotic,': [75], 'antiinflammatory,': [76], 'profibrinolytic': [78], 'properties.': [79], 'Recently': [80], 'phase': [83], 'III': [84], 'trial': [85, 102], '(PROWESS),': [86], 'alfa': [88, 182], 'demonstrated': [89], 'significantly': [90], 'reduced': [91], 'severe': [94, 114, 184], 'patients': [96, 186], 'at': [97], '28': [98], 'days.': [99], 'this': [101], 'important': [103], 'value': [104], 'factors': [105], 'for': [106], 'assessment': [108], 'costs': [110, 164, 169], 'outcomes': [112], 'were': [116], 'also': [117], 'considered.': [118], 'The': [119, 150], 'purpose': [120], 'present': [123], 'study': [124, 151], 'determine': [127], 'economic': [129], 'burden': [130], 'treatment': [133], 'with': [134], 'according': [137], 'cost-effectiveness': [140, 178], 'analysis': [141], 'based': [142], 'on': [143], 'data': [145], 'PROWESS': [148], 'trial.': [149], 'been': [153], 'adapted': [154], 'italian': [157], 'health': [158], 'environment.': [159], 'As': [160], 'regards': [161], 'per': [165, 170], 'surviving': [166], 'patient': [167], 'QALY': [171], '(Quality': [172], 'Adjusted': [173], 'Life': [174], 'Year),': [175], 'predicted': [177], 'ratio': [179], 'drotrecogin': [181], 'much': [188], 'lower': [189], 'than': [190], 'standard': [192], 'values': [193], 'considered': [194], 'acceptable': [196], 'international': [199], 'litterature.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1488314371', 'counts_by_year': [{'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-07T21:49:34.800746', 'created_date': '2016-06-24'}