Title: Effect of periodontal treatment on circulating CD34+ cells and peripheral vascular endothelial function: a randomized controlled trial
Abstract: Journal of Clinical PeriodontologyVolume 38, Issue 2 p. 148-156 Effect of periodontal treatment on circulating CD34+ cells and peripheral vascular endothelial function: a randomized controlled trial Xiao Li, Xiao Li Faculty of Dentistry, PeriodontologySearch for more papers by this authorHung Fat Tse, Hung Fat Tse Department of Medicine, Division of Cardiology, Queen Mary HospitalSearch for more papers by this authorKai Hang Yiu, Kai Hang Yiu Department of Medicine, Division of Cardiology, Queen Mary HospitalSearch for more papers by this authorLeonard Sheung Wai Li, Leonard Sheung Wai Li Department of Medicine, Tung Wah Hospital, The University of Hong Kong, Hong Kong SAR, ChinaSearch for more papers by this authorLijian Jin, Lijian Jin Faculty of Dentistry, PeriodontologySearch for more papers by this author Xiao Li, Xiao Li Faculty of Dentistry, PeriodontologySearch for more papers by this authorHung Fat Tse, Hung Fat Tse Department of Medicine, Division of Cardiology, Queen Mary HospitalSearch for more papers by this authorKai Hang Yiu, Kai Hang Yiu Department of Medicine, Division of Cardiology, Queen Mary HospitalSearch for more papers by this authorLeonard Sheung Wai Li, Leonard Sheung Wai Li Department of Medicine, Tung Wah Hospital, The University of Hong Kong, Hong Kong SAR, ChinaSearch for more papers by this authorLijian Jin, Lijian Jin Faculty of Dentistry, PeriodontologySearch for more papers by this author First published: 06 December 2010 https://doi.org/10.1111/j.1600-051X.2010.01651.xCitations: 36 Address:Prof. Lijian JinFaculty of DentistryPrince Philip Dental HospitalThe University of Hong Kong34 Hospital RoadHong Kong SARChinaE-mail: [email protected] Conflict of interest and source of funding The authors declare that they have no conflict of interests.This study was supported by the Hong Kong Research Grants Council (HKU 7518/05M and HKU766909M), The University of Hong Kong (CRCG Funds 200507176137, 200607176038, 200707176095 and 200907176052) and the Sun Chieh Yeh Heart Foundation. This clinical trial was registered at http://www.hkclinicaltrials.com, No. HKCTR-458. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Li X, Tse HF, Yiu KH, Li LSW, Jin L. Effect of periodontal treatment on circulating CD34+ cells and peripheral vascular endothelial function: a randomized controlled trial. J Clin Periodontol 2011; 38: 148–156. doi: 10.1111/j.1600-051X.2010.01651.x. Aim: Periodontal disease is associated with endothelial dysfunction and increased circulating progenitor cell (CPC) count. This study sought to investigate the effect of periodontal treatment on CPC count and vascular endothelial function. Materials and Methods: A single-blind, randomized controlled trial was conducted in 50 otherwise healthy subjects with moderate-to-severe chronic periodontitis. They were randomly assigned into Treatment group (n=25), in whom periodontal treatment was conducted immediately, and Control group (n=25), in whom periodontal treatment was postponed until the completion of this 3-month study. CPCs and peripheral endothelial function were evaluated at baseline and 3-month follow-up using flow cytometry and peripheral arterial tonometry, respectively. Results: Based on the intention-to-treat analysis, periodontal treatment exhibited neutral effects on endothelial function [treatment effect: 0.03, 95% confidence interval (CI): −0.29 to 0.35, p=0.85]. However, circulating CD34+ cells count significantly decreased in the Treatment group compared with the controls (treatment effect: −29.85 cells/μl, 95% CI: −52.62 to −7.08, p=0.011). The reduction of circulating CD34+ count was positively correlated with the decrease in sites% with bleeding on probing or periodontal pockets 4 mm. Conclusions: This study suggests that treatment of periodontitis has neutral effects on peripheral endothelial function but significantly decreases circulating CD34+ cell count. References Altman, D. G. & Bland, J. M. (2005) Treatment allocation by minimisation. British Medical Journal 330, 843. Behle, J. H., Sedaghatfar, M. H., Demmer, R. T., Wolf, D. L., Celenti, R., Kebschull, M., Belusko, P. B., Herrera-Abreu, M., Lalla, E. & Papapanou, P. N. (2009) Heterogeneity of systemic inflammatory responses to periodontal therapy. Journal of Clinical Periodontology 36, 287–294. 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