Abstract: Migraine is a common, disabling, typically episodic disorder of headache with associated symptoms of generalized sensitivity to afferent stimulation, such as to light or sound. Approximately one-third of migraine patients have an associated neurological disturbance referred to as the migraine aura. A small proportion of these patients with aura have weakness or paralysis in the limbs – hemiplegic migraine. When hemiplegic migraine runs in families, it is termed familial hemiplegic migraine. Three genes have been identified to produce this condition and each affects ion fluxes. The underlying pathophysiological process behind migraine aura is likely to be the cortical spreading depression of Leao. Advances in understanding this rare form of migraine will no doubt shed light on more common migraine aura and perhaps give insights into the biology of migraine more generally.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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