Title: The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease
Abstract: Obestatin is a 23 amino acid, ghrelin gene-derived peptide hormone produced in the stomach
and a range of other tissues throughout the body. While it was initially reported that obestatin
opposed the actions of ghrelin with regards to appetite and food intake, it is now clear that
obestatin is not an endogenous ghrelin antagonist of ghrelin, but it is a multi-functional
peptide hormone in its own right. In this review we will discuss the controversies associated
with the discovery of obestatin and explore emerging central and peripheral roles of
obestatin, roles in adipogenesis, pancreatic homeostasis and cancer.
Publication Year: 2011
Publication Date: 2011-04-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot