Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1485297825', 'doi': 'https://doi.org/10.1038/nrm1155', 'title': 'Calcium signalling: dynamics, homeostasis and remodelling', 'display_name': 'Calcium signalling: dynamics, homeostasis and remodelling', 'publication_year': 2003, 'publication_date': '2003-07-01', 'ids': {'openalex': 'https://openalex.org/W1485297825', 'doi': 'https://doi.org/10.1038/nrm1155', 'mag': '1485297825', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12838335'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nrm1155', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196724125', 'display_name': 'Nature Reviews Molecular Cell Biology', 'issn_l': '1471-0072', 'issn': ['1471-0072', '1471-0080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://lirias.kuleuven.be/bitstream/123456789/465710/1/Nat%20Rev%20Mol%20Cell%20Biol%202003%20Berridge.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078013249', 'display_name': 'Michael J. Berridge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1302113299', 'display_name': 'Babraham Institute', 'ror': 'https://ror.org/01d5qpn59', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1302113299', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Michael J. Berridge', 'raw_affiliation_strings': ['Laboratory of Molecular Signalling, The Babraham Institute, Babraham, UK'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Signalling, The Babraham Institute, Babraham, UK', 'institution_ids': ['https://openalex.org/I1302113299']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035998010', 'display_name': 'Martin D. Bootman', 'orcid': 'https://orcid.org/0000-0002-6447-3451'}, 'institutions': [{'id': 'https://openalex.org/I1302113299', 'display_name': 'Babraham Institute', 'ror': 'https://ror.org/01d5qpn59', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1302113299', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martin D. Bootman', 'raw_affiliation_strings': ['Laboratory of Molecular Signalling, The Babraham Institute, Babraham, UK'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Signalling, The Babraham Institute, Babraham, UK', 'institution_ids': ['https://openalex.org/I1302113299']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029465797', 'display_name': 'H. Llewelyn Roderick', 'orcid': 'https://orcid.org/0000-0001-7065-3523'}, 'institutions': [{'id': 'https://openalex.org/I1302113299', 'display_name': 'Babraham Institute', 'ror': 'https://ror.org/01d5qpn59', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1302113299', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'H. Llewelyn Roderick', 'raw_affiliation_strings': ['Laboratory of Molecular Signalling, The Babraham Institute, Babraham, UK'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Signalling, The Babraham Institute, Babraham, UK', 'institution_ids': ['https://openalex.org/I1302113299']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 20.995, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 5148, 'citation_normalized_percentile': {'value': 0.977273, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '4', 'issue': '7', 'first_page': '517', 'last_page': '529'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13415', 'display_name': 'Lysosomal Calcium Signaling in Physiology and Pathology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13415', 'display_name': 'Lysosomal Calcium Signaling in Physiology and Pathology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11204', 'display_name': 'Calcium Signaling and Ion Channels in Sensation', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/signalling', 'display_name': 'Signalling', 'score': 0.7861005}, {'id': 'https://openalex.org/keywords/calcium-signaling', 'display_name': 'Calcium Signaling', 'score': 0.630217}, {'id': 'https://openalex.org/keywords/cell-signaling', 'display_name': 'Cell Signaling', 'score': 0.562053}, {'id': 'https://openalex.org/keywords/homeostasis', 'display_name': 'Homeostasis', 'score': 0.5499392}, {'id': 'https://openalex.org/keywords/dynamics', 'display_name': 'Dynamics (music)', 'score': 0.53485906}, {'id': 'https://openalex.org/keywords/lysosomal-calcium-signaling', 'display_name': 'Lysosomal Calcium Signaling', 'score': 0.524883}, {'id': 'https://openalex.org/keywords/calcium-channels', 'display_name': 'Calcium Channels', 'score': 0.506661}], 'concepts': [{'id': 'https://openalex.org/C39743133', 'wikidata': 'https://www.wikidata.org/wiki/Q3262595', 'display_name': 'Signalling', 'level': 2, 'score': 0.7861005}, {'id': 'https://openalex.org/C201571599', 'wikidata': 'https://www.wikidata.org/wiki/Q5018840', 'display_name': 'Calcium signaling', 'level': 3, 'score': 0.71506137}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.59675264}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.57096153}, {'id': 'https://openalex.org/C63645605', 'wikidata': 'https://www.wikidata.org/wiki/Q103191', 'display_name': 'Homeostasis', 'level': 2, 'score': 0.5499392}, {'id': 'https://openalex.org/C145912823', 'wikidata': 'https://www.wikidata.org/wiki/Q113558', 'display_name': 'Dynamics (music)', 'level': 2, 'score': 0.53485906}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4758282}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.43227077}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.36048973}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.29934436}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.133982}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015290', 'descriptor_name': 'Second Messenger Systems', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015220', 'descriptor_name': 'Calcium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015220', 'descriptor_name': 'Calcium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015290', 'descriptor_name': 'Second Messenger Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nrm1155', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196724125', 'display_name': 'Nature Reviews Molecular Cell Biology', 'issn_l': '1471-0072', 'issn': ['1471-0072', '1471-0080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://lirias.kuleuven.be/handle/123456789/465710', 'pdf_url': 'https://lirias.kuleuven.be/bitstream/123456789/465710/1/Nat%20Rev%20Mol%20Cell%20Biol%202003%20Berridge.pdf', 'source': {'id': 'https://openalex.org/S4306401954', 'display_name': 'Lirias (KU Leuven)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I99464096', 'host_organization_name': 'KU Leuven', 'host_organization_lineage': ['https://openalex.org/I99464096'], 'host_organization_lineage_names': ['KU Leuven'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12838335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://lirias.kuleuven.be/handle/123456789/465710', 'pdf_url': 'https://lirias.kuleuven.be/bitstream/123456789/465710/1/Nat%20Rev%20Mol%20Cell%20Biol%202003%20Berridge.pdf', 'source': {'id': 'https://openalex.org/S4306401954', 'display_name': 'Lirias (KU Leuven)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I99464096', 'host_organization_name': 'KU Leuven', 'host_organization_lineage': ['https://openalex.org/I99464096'], 'host_organization_lineage_names': ['KU Leuven'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 120, 'referenced_works': ['https://openalex.org/W1480735239', 'https://openalex.org/W1517851992', 'https://openalex.org/W1533702935', 'https://openalex.org/W1597131590', 'https://openalex.org/W1599277155', 'https://openalex.org/W1605990605', 'https://openalex.org/W1615545200', 'https://openalex.org/W1650401181', 'https://openalex.org/W1666469474', 'https://openalex.org/W1781581231', 'https://openalex.org/W1884928912', 'https://openalex.org/W1888295889', 'https://openalex.org/W1965350385', 'https://openalex.org/W1968816568', 'https://openalex.org/W1970093299', 'https://openalex.org/W1970815708', 'https://openalex.org/W1972557433', 'https://openalex.org/W1974535915', 'https://openalex.org/W1976151623', 'https://openalex.org/W1976405409', 'https://openalex.org/W1977150932', 'https://openalex.org/W1977703065', 'https://openalex.org/W1978053844', 'https://openalex.org/W1980830385', 'https://openalex.org/W1982486909', 'https://openalex.org/W1983188620', 'https://openalex.org/W1983820893', 'https://openalex.org/W1983913693', 'https://openalex.org/W1987651777', 'https://openalex.org/W1990758206', 'https://openalex.org/W1997778815', 'https://openalex.org/W2001749475', 'https://openalex.org/W2003187190', 'https://openalex.org/W2003784972', 'https://openalex.org/W2004810045', 'https://openalex.org/W2006221479', 'https://openalex.org/W2006483772', 'https://openalex.org/W2010795846', 'https://openalex.org/W2011182719', 'https://openalex.org/W2013624095', 'https://openalex.org/W2014264816', 'https://openalex.org/W2017763545', 'https://openalex.org/W2021153400', 'https://openalex.org/W2022729995', 'https://openalex.org/W2023541046', 'https://openalex.org/W2023732918', 'https://openalex.org/W2025642842', 'https://openalex.org/W2027204345', 'https://openalex.org/W2030891380', 'https://openalex.org/W2031943544', 'https://openalex.org/W2036028191', 'https://openalex.org/W2036287496', 'https://openalex.org/W2038392013', 'https://openalex.org/W2040206752', 'https://openalex.org/W2046470310', 'https://openalex.org/W2047067502', 'https://openalex.org/W2049807537', 'https://openalex.org/W2051450681', 'https://openalex.org/W2053330560', 'https://openalex.org/W2058861807', 'https://openalex.org/W2059545632', 'https://openalex.org/W2059675111', 'https://openalex.org/W2061603242', 'https://openalex.org/W2065368005', 'https://openalex.org/W2067686089', 'https://openalex.org/W2068613600', 'https://openalex.org/W2070121353', 'https://openalex.org/W2070518369', 'https://openalex.org/W2073574276', 'https://openalex.org/W2073706613', 'https://openalex.org/W2075982463', 'https://openalex.org/W2076056288', 'https://openalex.org/W2077757600', 'https://openalex.org/W2077870164', 'https://openalex.org/W2079457311', 'https://openalex.org/W2080955459', 'https://openalex.org/W2082502466', 'https://openalex.org/W2083837898', 'https://openalex.org/W2084332777', 'https://openalex.org/W2086076030', 'https://openalex.org/W2088264073', 'https://openalex.org/W2089033487', 'https://openalex.org/W2089063033', 'https://openalex.org/W2092613581', 'https://openalex.org/W2092924768', 'https://openalex.org/W2093923609', 'https://openalex.org/W2095121497', 'https://openalex.org/W2095869636', 'https://openalex.org/W2096013132', 'https://openalex.org/W2097331211', 'https://openalex.org/W2097939257', 'https://openalex.org/W2098275443', 'https://openalex.org/W2105014609', 'https://openalex.org/W2109213213', 'https://openalex.org/W2110375403', 'https://openalex.org/W2114942701', 'https://openalex.org/W2115032762', 'https://openalex.org/W2117527010', 'https://openalex.org/W2117805913', 'https://openalex.org/W2121003362', 'https://openalex.org/W2123113436', 'https://openalex.org/W2133742018', 'https://openalex.org/W2134656239', 'https://openalex.org/W2135011583', 'https://openalex.org/W2136285855', 'https://openalex.org/W2136875701', 'https://openalex.org/W2140313595', 'https://openalex.org/W2140313980', 'https://openalex.org/W2156029588', 'https://openalex.org/W2156433522', 'https://openalex.org/W2159560209', 'https://openalex.org/W2159659012', 'https://openalex.org/W2159977558', 'https://openalex.org/W2160385558', 'https://openalex.org/W2161440135', 'https://openalex.org/W2162489885', 'https://openalex.org/W2164020057', 'https://openalex.org/W2170579633', 'https://openalex.org/W4244420109', 'https://openalex.org/W4252020624'], 'related_works': ['https://openalex.org/W562261238', 'https://openalex.org/W4367835058', 'https://openalex.org/W4210298392', 'https://openalex.org/W3012992526', 'https://openalex.org/W2077767442', 'https://openalex.org/W2018800923', 'https://openalex.org/W2005549605', 'https://openalex.org/W1973994948', 'https://openalex.org/W1584469354', 'https://openalex.org/W1485297825'], 'abstract_inverted_index': {'Ca2+': [0, 40, 53, 57, 59], 'is': [1, 24], 'a': [2, 10, 61], 'highly': [3, 38], 'versatile': [4], 'intracellular': [5, 56], 'signal': [6], 'that': [7, 73], 'operates': [8], 'over': [9], 'wide': [11], 'temporal': [12, 35], 'range': [13], 'to': [14, 26], 'regulate': [15, 42], 'many': [16], 'different': [17, 32], 'cellular': [18], 'processes.': [19], 'An': [20], 'extensive': [21], 'Ca2+-signalling': [22], 'toolkit': [23], 'used': [25], 'assemble': [27], 'signalling': [28, 71], 'systems': [29, 72], 'with': [30], 'very': [31], 'spatial': [33], 'and': [34, 81], 'dynamics.': [36], 'Rapid': [37], 'localized': [39], 'spikes': [41], 'fast': [43], 'responses,': [44], 'whereas': [45], 'slower': [46], 'responses': [47], 'are': [48, 74], 'controlled': [49], 'by': [50], 'repetitive': [51], 'global': [52], 'transients': [54], 'or': [55], 'waves.': [58], 'has': [60], 'direct': [62], 'role': [63], 'in': [64, 78], 'controlling': [65], 'the': [66], 'expression': [67], 'patterns': [68], 'of': [69], 'its': [70], 'constantly': [75], 'being': [76], 'remodelled': [77], 'both': [79], 'health': [80], 'disease.': [82]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1485297825', 'counts_by_year': [{'year': 2024, 'cited_by_count': 145}, {'year': 2023, 'cited_by_count': 258}, {'year': 2022, 'cited_by_count': 264}, {'year': 2021, 'cited_by_count': 242}, {'year': 2020, 'cited_by_count': 276}, {'year': 2019, 'cited_by_count': 259}, {'year': 2018, 'cited_by_count': 259}, {'year': 2017, 'cited_by_count': 273}, {'year': 2016, 'cited_by_count': 262}, {'year': 2015, 'cited_by_count': 260}, {'year': 2014, 'cited_by_count': 239}, {'year': 2013, 'cited_by_count': 271}, {'year': 2012, 'cited_by_count': 310}], 'updated_date': '2024-09-18T18:27:24.939436', 'created_date': '2016-06-24'}