Publication Information

{'id': 'https://openalex.org/W1485150548', 'doi': 'https://doi.org/10.1128/jb.176.10.2999-3006.1994', 'title': 'Determining the DNA sequence elements required for binding integration host factor to two different target sites', 'display_name': 'Determining the DNA sequence elements required for binding integration host factor to two different target sites', 'publication_year': 1994, 'publication_date': '1994-05-01', 'ids': {'openalex': 'https://openalex.org/W1485150548', 'doi': 'https://doi.org/10.1128/jb.176.10.2999-3006.1994', 'mag': '1485150548', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8188600', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/205457'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jb.176.10.2999-3006.1994', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S133274750', 'display_name': 'Journal of Bacteriology', 'issn_l': '0021-9193', 'issn': ['0021-9193', '1067-8832', '1098-5530'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1128/jb.176.10.2999-3006.1994', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080539334', 'display_name': 'Laura M. Hales', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L M Hales', 'raw_affiliation_strings': ['Department of Microbiology, University of Illinois, Urbana 61801.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Illinois, Urbana 61801.', 'institution_ids': ['https://openalex.org/I157725225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048798724', 'display_name': 'Richard Gumport', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R I Gumport', 'raw_affiliation_strings': ['Department of Microbiology, University of Illinois, Urbana 61801.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Illinois, Urbana 61801.', 'institution_ids': ['https://openalex.org/I157725225']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052602824', 'display_name': 'Jeffrey F. Gardner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J F Gardner', 'raw_affiliation_strings': ['Department of Microbiology, University of Illinois, Urbana 61801.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Illinois, Urbana 61801.', 'institution_ids': ['https://openalex.org/I157725225']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.355, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 75, 'citation_normalized_percentile': {'value': 0.921564, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '176', 'issue': '10', 'first_page': '2999', 'last_page': '3006'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11048', 'display_name': 'Bacteriophages and microbial interactions', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Genetics and Biotechnology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sequence', 'display_name': 'Sequence (biology)', 'score': 0.45978692}, {'id': 'https://openalex.org/keywords/conserved-sequence', 'display_name': 'Conserved sequence', 'score': 0.4582166}, {'id': 'https://openalex.org/keywords/host-factor', 'display_name': 'Host factors', 'score': 0.43564686}, {'id': 'https://openalex.org/keywords/dna-binding-site', 'display_name': 'DNA binding site', 'score': 0.4259874}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.79298997}, {'id': 'https://openalex.org/C54985914', 'wikidata': 'https://www.wikidata.org/wiki/Q1295754', 'display_name': 'Consensus sequence', 'level': 4, 'score': 0.782415}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.76156014}, {'id': 'https://openalex.org/C2776441376', 'wikidata': 'https://www.wikidata.org/wiki/Q165028', 'display_name': 'Bacteriophage', 'level': 4, 'score': 0.66521055}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.5752814}, {'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.5672646}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.48579574}, {'id': 'https://openalex.org/C2778112365', 'wikidata': 'https://www.wikidata.org/wiki/Q3511065', 'display_name': 'Sequence (biology)', 'level': 2, 'score': 0.45978692}, {'id': 'https://openalex.org/C199216141', 'wikidata': 'https://www.wikidata.org/wiki/Q4995178', 'display_name': 'Conserved sequence', 'level': 4, 'score': 0.4582166}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.4438144}, {'id': 'https://openalex.org/C2777627835', 'wikidata': 'https://www.wikidata.org/wiki/Q16963978', 'display_name': 'Host factor', 'level': 3, 'score': 0.43564686}, {'id': 'https://openalex.org/C3662595', 'wikidata': 'https://www.wikidata.org/wiki/Q5205743', 'display_name': 'DNA binding site', 'level': 5, 'score': 0.4259874}, {'id': 'https://openalex.org/C51639874', 'wikidata': 'https://www.wikidata.org/wiki/Q167149', 'display_name': 'Plasma protein binding', 'level': 2, 'score': 0.42333114}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.4183344}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4161957}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.39632618}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18771556}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17375293}, {'id': 'https://openalex.org/C3017666073', 'wikidata': 'https://www.wikidata.org/wiki/Q1764062', 'display_name': 'Base sequence', 'level': 3, 'score': 0.13273418}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.12957361}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.12695146}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010582', 'descriptor_name': 'Bacteriophage lambda', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010582', 'descriptor_name': 'Bacteriophage lambda', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016384', 'descriptor_name': 'Consensus Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034982', 'descriptor_name': 'Integration Host Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017422', 'descriptor_name': 'Sequence Analysis, DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jb.176.10.2999-3006.1994', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S133274750', 'display_name': 'Journal of Bacteriology', 'issn_l': '0021-9193', 'issn': ['0021-9193', '1067-8832', '1098-5530'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc205457', 'pdf_url': 'https://europepmc.org/articles/pmc205457?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC205457', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8188600', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jb.176.10.2999-3006.1994', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S133274750', 'display_name': 'Journal of Bacteriology', 'issn_l': '0021-9193', 'issn': ['0021-9193', '1067-8832', '1098-5530'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1017438797', 'https://openalex.org/W1243723833', 'https://openalex.org/W1523079115', 'https://openalex.org/W1544705562', 'https://openalex.org/W1546783991', 'https://openalex.org/W1578950175', 'https://openalex.org/W1851242167', 'https://openalex.org/W1933613941', 'https://openalex.org/W1946198865', 'https://openalex.org/W1973310140', 'https://openalex.org/W1978974322', 'https://openalex.org/W2003045418', 'https://openalex.org/W2011093920', 'https://openalex.org/W2018732451', 'https://openalex.org/W2020631738', 'https://openalex.org/W2032767707', 'https://openalex.org/W2044899180', 'https://openalex.org/W2078089931', 'https://openalex.org/W2082927796', 'https://openalex.org/W2090631246', 'https://openalex.org/W2099105015', 'https://openalex.org/W2118142087', 'https://openalex.org/W2127385277', 'https://openalex.org/W2128745387', 'https://openalex.org/W2272873059', 'https://openalex.org/W2404978881', 'https://openalex.org/W579964744'], 'related_works': ['https://openalex.org/W2412031876', 'https://openalex.org/W2144857133', 'https://openalex.org/W2130150170', 'https://openalex.org/W2115769169', 'https://openalex.org/W2099810742', 'https://openalex.org/W2041348782', 'https://openalex.org/W2036927633', 'https://openalex.org/W2003184006', 'https://openalex.org/W1979206664', 'https://openalex.org/W1927891221'], 'abstract_inverted_index': {'Binding': [0], 'sites': [1, 82, 109], 'for': [2, 59, 127, 144, 191], 'the': [3, 22, 66, 78, 90, 104, 111, 117, 132, 137, 148, 166, 176, 179, 195, 208, 215, 219], 'Escherichia': [4], 'coli': [5], 'protein': [6], 'integration': [7], 'host': [8], 'factor': [9], '(IHF)': [10], 'include': [11], 'a': [12, 49, 101, 203, 222], 'set': [13], 'of': [14, 69, 85, 202, 207, 221], 'conserved': [15], 'bases': [16, 177], 'that': [17, 122, 159, 186, 200, 218], 'can': [18], 'be': [19, 57], 'summarized': [20], 'by': [21, 88], 'consensus': [23, 113, 139, 181, 211], 'sequence': [24, 72], 'WATCAANNNNTTR': [25], '(W': [26], 'is': [27, 32, 38, 48, 142, 189], 'dA': [28, 33], 'or': [29, 34, 161], 'dT,': [30], 'R': [31], 'dG,': [35], 'and': [36, 80], 'N': [37], 'any': [39], 'nucleotide).': [40], 'However,': [41], 'additional': [42], "5'-proximal": [43], 'bases,': [44], 'whose': [45], 'common': [46], 'feature': [47], 'high': [50], 'dA+dT': [51], 'content,': [52], 'are': [53, 125], 'also': [54], 'thought': [55], 'to': [56, 74, 77, 98, 129, 131, 147, 165, 194], 'required': [58, 126], 'binding': [60, 76, 146, 164, 193], 'at': [61, 107], 'some': [62], 'sites.': [63], 'We': [64, 198], 'examine': [65], 'relative': [67], 'contribution': [68], 'these': [70], 'two': [71], 'elements': [73, 124], 'IHF': [75, 95, 128, 145, 163, 192, 226], "H'": [79, 108, 133], 'H1': [81, 149, 167, 196, 209], 'in': [83, 103, 175, 178], 'attP': [84], 'bacteriophage': [86, 91], 'lambda': [87], 'using': [89], 'P22-based': [92], 'challenge-phage': [93, 105], 'system.': [94], 'was': [96], 'unable': [97], 'act': [99], 'as': [100], 'repressor': [102], 'assay': [106], 'containing': [110], 'core': [112, 138, 180, 210], 'element': [114, 182, 205, 212, 224], 'but': [115], 'lacking': [116], 'dA+dT-rich': [118, 155, 204, 223], 'element.': [119], 'This': [120], 'indicates': [121], 'both': [123], 'bind': [130], 'site.': [134, 197], 'In': [135], 'contrast,': [136], 'determinant': [140, 188], 'alone': [141], 'sufficient': [143, 190], 'site,': [150], 'which': [151], 'lacks': [152], 'an': [153], 'upstream': [154, 206], 'region.': [156], 'Fifty': [157], 'mutants': [158], 'decreased': [160], 'eliminated': [162], 'site': [168], 'were': [169], 'isolated.': [170], 'Sequence': [171], 'analysis': [172], 'showed': [173], 'changes': [174], 'only,': [183], 'further': [184], 'indicating': [185], 'this': [187], 'found': [199], 'placement': [201], 'significantly': [213], 'increased': [214], 'affinity,': [216], 'suggesting': [217], 'presence': [220], 'enhances': [225], 'binding.': [227]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1485150548', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T15:56:23.163751', 'created_date': '2016-06-24'}