Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1485090153', 'doi': 'https://doi.org/10.1016/s0021-9258(20)64349-6', 'title': 'Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption', 'display_name': 'Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption', 'publication_year': 1991, 'publication_date': '1991-03-01', 'ids': {'openalex': 'https://openalex.org/W1485090153', 'doi': 'https://doi.org/10.1016/s0021-9258(20)64349-6', 'mag': '1485090153', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1999430'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(20)64349-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(20)64349-6', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034112083', 'display_name': 'John C. Fyfe', 'orcid': 'https://orcid.org/0000-0002-5774-3150'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J C Fyfe', 'raw_affiliation_strings': ['Section of Medical Genetics, Veterinary School of the University of Pennsyluania, Philadelphia, Pennsylvania 19104-6010'], 'affiliations': [{'raw_affiliation_string': 'Section of Medical Genetics, Veterinary School of the University of Pennsyluania, Philadelphia, Pennsylvania 19104-6010', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113278003', 'display_name': 'K.S. Ramanujam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204308271', 'display_name': 'Medical College of Wisconsin', 'ror': 'https://ror.org/00qqv6244', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204308271']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K S Ramanujam', 'raw_affiliation_strings': ['Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226', 'institution_ids': ['https://openalex.org/I204308271']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113704386', 'display_name': 'Krishnamurthy Ramaswamy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1322918889', 'display_name': 'United States Department of Veterans Affairs', 'ror': 'https://ror.org/05rsv9s98', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1322918889']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K Ramaswamy', 'raw_affiliation_strings': ['Veterans Administration Medical Center, Milwaukee, Wisconsin 53226'], 'affiliations': [{'raw_affiliation_string': 'Veterans Administration Medical Center, Milwaukee, Wisconsin 53226', 'institution_ids': ['https://openalex.org/I1322918889']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109928533', 'display_name': 'Donald F. Patterson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D F Patterson', 'raw_affiliation_strings': ['Section of Medical Genetics, Veterinary School of the University of Pennsyluania, Philadelphia, Pennsylvania 19104-6010'], 'affiliations': [{'raw_affiliation_string': 'Section of Medical Genetics, Veterinary School of the University of Pennsyluania, Philadelphia, Pennsylvania 19104-6010', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5114019674', 'display_name': 'Bellur Seetharam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204308271', 'display_name': 'Medical College of Wisconsin', 'ror': 'https://ror.org/00qqv6244', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204308271']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'B Seetharam', 'raw_affiliation_strings': ['Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226', 'institution_ids': ['https://openalex.org/I204308271']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.469, 'has_fulltext': False, 'cited_by_count': 106, 'citation_normalized_percentile': {'value': 0.952716, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '266', 'issue': '7', 'first_page': '4489', 'last_page': '4494'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12460', 'display_name': 'Pediatric Hepatobiliary Diseases and Treatments', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 0.9855, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intrinsic-factor', 'display_name': 'Intrinsic factor', 'score': 0.9415754}, {'id': 'https://openalex.org/keywords/brush-border', 'display_name': 'Brush border', 'score': 0.7439505}], 'concepts': [{'id': 'https://openalex.org/C2780676250', 'wikidata': 'https://www.wikidata.org/wiki/Q187706', 'display_name': 'Cobalamin', 'level': 3, 'score': 0.98263055}, {'id': 'https://openalex.org/C2777569460', 'wikidata': 'https://www.wikidata.org/wiki/Q410153', 'display_name': 'Intrinsic factor', 'level': 3, 'score': 0.9415754}, {'id': 'https://openalex.org/C5426402', 'wikidata': 'https://www.wikidata.org/wiki/Q2462753', 'display_name': 'Brush border', 'level': 4, 'score': 0.7439505}, {'id': 'https://openalex.org/C2780439177', 'wikidata': 'https://www.wikidata.org/wiki/Q1442923', 'display_name': 'Malabsorption', 'level': 2, 'score': 0.6966754}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49244937}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42556933}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33956045}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3379233}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.271491}, {'id': 'https://openalex.org/C2779750884', 'wikidata': 'https://www.wikidata.org/wiki/Q187706', 'display_name': 'Vitamin B12', 'level': 2, 'score': 0.26410604}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24592552}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(20)64349-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(20)64349-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1486018834', 'https://openalex.org/W1525820657', 'https://openalex.org/W154723595', 'https://openalex.org/W1573759787', 'https://openalex.org/W1608095573', 'https://openalex.org/W1642797237', 'https://openalex.org/W1775749144', 'https://openalex.org/W1976603658', 'https://openalex.org/W1978911402', 'https://openalex.org/W1999235861', 'https://openalex.org/W2001992996', 'https://openalex.org/W2009708970', 'https://openalex.org/W2014321075', 'https://openalex.org/W2016609687', 'https://openalex.org/W2030459881', 'https://openalex.org/W2034616847', 'https://openalex.org/W2041184867', 'https://openalex.org/W2042386026', 'https://openalex.org/W2055252581', 'https://openalex.org/W2075592077', 'https://openalex.org/W2091249772', 'https://openalex.org/W2094068264', 'https://openalex.org/W2098549295', 'https://openalex.org/W2100837269', 'https://openalex.org/W2111817213', 'https://openalex.org/W2121559423', 'https://openalex.org/W2152708819', 'https://openalex.org/W2314184124', 'https://openalex.org/W2338880658', 'https://openalex.org/W2395333890', 'https://openalex.org/W2628074563', 'https://openalex.org/W2905618940', 'https://openalex.org/W72634974', 'https://openalex.org/W92299947'], 'related_works': ['https://openalex.org/W2419144509', 'https://openalex.org/W2416081101', 'https://openalex.org/W2330984808', 'https://openalex.org/W2319008055', 'https://openalex.org/W2121559423', 'https://openalex.org/W2101642347', 'https://openalex.org/W2062606582', 'https://openalex.org/W181061236', 'https://openalex.org/W1516197200', 'https://openalex.org/W1485090153'], 'abstract_inverted_index': {'Ligand': [0], 'binding': [1], 'activity': [2, 59, 72, 86], 'of': [3, 17, 28, 60, 80, 84, 90, 95, 117, 136, 144, 162, 172, 202, 212, 248, 254], 'intrinsic': [4, 111], 'factor-cobalamin': [5, 112], 'receptor': [6], '(IFCR)': [7], 'was': [8, 65, 78, 98, 113, 121, 228], 'determined': [9], 'in': [10, 73, 87, 115, 124, 156, 238, 259], 'homogenates': [11, 64, 77], 'and': [12, 19, 49, 92, 100, 120, 126, 139, 141, 146, 175, 199, 256], 'isolated': [13], 'brush-border': [14], 'membranes': [15], '(BBM)': [16], 'ileum': [18, 91], 'kidney': [20, 76, 171], 'from': [21, 170], 'dogs': [22, 97, 177], 'exhibiting': [23], 'simple': [24], 'autosomal': [25], 'recessive': [26], 'inheritance': [27], 'selective': [29], 'cobalamin': [30, 236], 'malabsorption': [31, 237], '(Fyfe,': [32], 'J.': [33, 47], 'C.,': [34], 'Giger,': [35], 'U.,': [36], 'Hall,': [37], 'C.': [38], 'A.,': [39, 45], 'Jezyk,': [40], 'P.': [41], 'F.,': [42], 'Klumpp,': [43], 'S.': [44], 'Levine,': [46], 'S.,': [48], 'Patterson,': [50], 'D.': [51], 'F.': [52], '(1991)': [53], 'Pediatr.': [54], 'Res.': [55], '29,': [56], '24-31).': [57], 'IFCR': [58, 71, 85, 153, 165, 192, 227, 249, 255], 'affected': [61, 74, 96, 125, 131, 163, 176, 190, 225], 'dog': [62, 75, 132, 191, 226], 'ileal': [63, 133, 158], '3-4-fold': [66], 'higher': [67], 'than': [68, 103, 196], 'normal': [69, 127, 174], 'whereas': [70], 'one-tenth': [79], 'normal.': [81, 149], 'The': [82, 106], 'recovery': [83], 'the': [88, 122, 130, 157, 189, 197, 203, 224], 'BBM': [89, 116, 161, 246], 'renal': [93, 160], 'cortex': [94], '30-': [99], '20-fold': [101], 'less': [102], 'normal,': [104, 198], 'respectively.': [105], 'dissociation': [107], 'constant': [108], '(Kd)': [109], 'for': [110], 'similar': [114], 'both': [118, 173, 213], 'tissues': [119], 'same': [123], 'dogs.': [128, 164], 'In': [129], 'BBM,': [134], 'activities': [135], 'alkaline': [137], 'phosphatase': [138], 'sucrase-isomaltase': [140], 'vesicular': [142], 'transport': [143], 'glucose': [145], 'Na(+)-taurocholate': [147], 'were': [148, 215], 'Immunoblots': [150], 'showed': [151], 'no': [152], 'cross-reactive': [154], 'material': [155], 'or': [159], 'purified': [166, 204], 'by': [167, 244], 'affinity': [168], 'chromatography': [169], 'had': [178, 193], 'an': [179, 260], 'Mr': [180], '=': [181], '230,000.': [182], 'However,': [183], 'amino': [184], 'acid': [185], 'analysis': [186], 'revealed': [187, 206], 'that': [188, 235], 'more': [194], 'lysine': [195], 'protease': [200], 'cleavage': [201], 'IFCRs': [205], 'different': [207], 'peptide': [208, 218], 'maps.': [209], 'Asparagine-linked': [210], 'oligosaccharides': [211], 'proteins': [214], 'sensitive': [216], 'to': [217, 251], 'N-glycosidase': [219], 'F': [220], 'cleavage,': [221], 'but': [222], 'only': [223], 'endoglycosidase': [229], 'H': [230], 'sensitive.': [231], 'These': [232], 'results': [233], 'suggest': [234], 'this': [239], 'canine': [240], 'family': [241], 'is': [242], 'caused': [243], 'inefficient': [245], 'expression': [247], 'due': [250], 'a': [252], 'mutation': [253], 'its': [257], 'retention': [258], 'early': [261], 'biosynthetic': [262], 'compartment.': [263]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1485090153', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-18T21:19:00.085951', 'created_date': '2016-06-24'}