Title: Abstract 94: Melatonin inhibits stemness of glioblastoma cancer stem-like cells via regulation of histone methylation
Abstract: Abstract The pineal gland hormone melatonin (N-acetyl-5-methoxytryptamine) is well known as an anticancer effector. Recently, a variety of studies have shown that melatonin induces apoptosis in various cancer cell types such as colon cancer, Ewing sarcoma, hepatic cancer, prostate cancer and breast cancer cells. Glioblastoma cancer stem-like cells (GCSLC) are the most common and aggressive primary brain tumor in adults. In the present study, we found that melatonin significantly decreased the sphere formation of GCSLC, and attenuated the expression of c-Myc genes. Furthermore, melatonin suppressed expression of H3K4me3 and H3K79me3 around c-Myc promoter region by Western blotting and Chip assay. Of note, melatonin suppressed the expression of several stemness markers including nestin in GCSLC. Overall, our findings suggest melatonin as a potent anticancer stem cell agent for GCSLC. Citation Format: Hyemin Lee, Ji Hoon Jung, Hyun Joo Lee, Myoung Seok Jeong, Deok-Beom Jung, Hee Young Kwon, Sung-Hoon Kim. Melatonin inhibits stemness of glioblastoma cancer stem-like cells via regulation of histone methylation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 94. doi:10.1158/1538-7445.AM2015-94
Publication Year: 2015
Publication Date: 2015-08-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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