Title: Buoyancy-driven centripetal pumping for nested sample preparation in bioassays
Abstract:In this paper we present a method of buoyancy-driven centripetal pumping utilizing a heavy, waterimmiscible liquid to displace an aqueous sample radially inwards against the prevailing centrifugal for...In this paper we present a method of buoyancy-driven centripetal pumping utilizing a heavy, waterimmiscible liquid to displace an aqueous sample radially inwards against the prevailing centrifugal force. Using formerly introduced dissolvable-film valving, we demonstrate metering and bidirectional periodical pumping of a single sample in the radial direction. We then show integrated sample discretisation, metering and buoyancy-driven inward pumping in a microfluidic structure designed towards multi-parameter bioassays. This structure permits centrifugation of sample on the periphery of a disc (where the centrifugal field p) and proves a high degree of metering accuracy better than 1.2%.Read More
Publication Year: 2014
Publication Date: 2014-10-25
Language: en
Type: article
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Cited By Count: 3
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