Abstract: Endogenous opioid peptides derive from four different precursor proteins. Proopiomelanocortin (POMC) yields ACTH and endorphins, mainly β-endorphin (β-END). Proenkephalin (PENK) generates enkephalins (ENK), predominantly Met-enkephalin (MENK) and Leu-enkephalin (LENK). The proteolysis of prodynorphin (PDYN) results in the formation of dynorphin A (DYN A) and B (DYN B) (Przewlocki 2004; Przewlocki and Przewlocka 2005). Other POMC derivatives are endomorphins which are the cleavage products of a larger precursor molecule that yet has not been identified (Fichna et al. 2007).
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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