Title: Anti-oxidative Effects of Taraxaci Herba and Protective Effects on Human HaCaT Keratinocyte
Abstract: ABSTRACT Objectives :This study was carried out to investigate anti-oxidative effect s of Taraxaci Herba (TH) and protective effects on Human HaCaT keratinocyte.Methods : Anti-oxidative effects were measured by estimating the amount o f total phenolics and flavonoids. In addition, DPPH free radical scavenging activitie s were estimated. Protective effects of TH on HaCaT keratinocytes against oxidative stress induced by h ydrogen peroxide were also measured. Results : In our results, treatment with TH did not show cytotoxicity on HaCaT keratinocyte beneath the concentration of 200 ㎍/㎖. 42.64±1.90 ㎍/㎖ of total phenolics and 28.09±1.84 ㎍/㎖ of flavonoids was detected from TH ethanol extract. In addition, D PPH free radical scavenging activities of TH were elevated in dose-dependent manner. In add ition, The value of half maximal inhibitory concentration (IC 50 ) was 165.5 ㎍/㎖. Finally, TH showed protective effect against cell death of HaCaT cell induced by hydrogen peroxide significantly.Conclusions : In conclusion, these results suggest that TH may have anti-oxidantic action in human skin and also suggest the possibility as cosmetic material.Key words : Taraxaci Herba; anti-oxidative effect; HaCaT keratinocyte
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 6
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