Title: Cofactors and Coenzymes | Biochemistry of Thiamine and Thiamine Phosphate Compounds
Abstract: Thiamine (vitamin B1) is an essential molecule for all living organisms. It is the precursor for several phosphorylated derivatives, the most important being the coenzyme thiamine diphosphate (ThDP). Thiamine is transported into cells by specific transporters and pyrophosphorylated to ThDP in the cytosol. ThDP is an essential cofactor for cellular oxidative energy metabolism. Thiamine deficiency disorders lead to severe nervous system lesion and cardiac failure. ThDP is the precursor for two triphosphorylated derivatives, thiamine triphosphate and adenosine thiamine triphosphate, with unknown function but present in all three kingdoms of life.
Publication Year: 2021
Publication Date: 2021-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 5
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