Title: Helix–Loop–Helix (bHLH) Proteins: Hes Family
Abstract: The Hes basic helix–loop–helix (bHLH) transcriptional repressor genes antagonize proneural genes, thereby inhibiting neurogenesis, maintaining neural progenitors, and promoting gliogenesis. In addition, Hes genes regulate formation of boundaries, which partition the neural tube into compartments and function as organizing centers. In the absence of Hes genes, progenitors prematurely differentiate into neurons at the expense of later-born cell types, while organizing centers are lost, thereby disrupting a structure key to the establishment of regional identity. Thus, Hes genes play an essential role in the production of neural cell types in the normal number and full diversity by controlling the development of neural progenitors and organizing centers.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot