Abstract: It is well established that inositol 1,4,5-trisphosphate and Ca2+ are able to mediate signal transduction by opening intracellular Ca2+ channels located on intracellular membranes. These messengers do this by activating IP3 and ryanodine receptors, respectively. Nonetheless, in recent years evidence has emerged that other molecules may mediate intracellular Ca2+ release, either by the modulation of these two channels or via the activation of further, previously unknown, channels. Derivatives of nicotinamide adenine dinucleotide and NADP have been shown to be able to induce Ca2+ release via both mechanisms. In particular, cyclic ADP ribose acts on particular subtypes of the ryanodine receptor, while nicotinic acid adenine dinucleotide phosphate releases Ca2+ via a novel and distinct mechanism.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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