Title: Intracellular Calcium Responses to Hypoxia and Cyanide in Cultured Type I Cells from Newborn and Adult Rabbits
Abstract: Carotid chemoreceptor responses to hypoxia and CO2 are weak just after birth and take time to mature to adult levels (Kholwadwala & Donnelly, 1992, Marchai et al, 1992, Carroll et al, 1993) The mechanisms underlying changes in carotid chemoreceptor function during development are not known Possible mechanisms include developmental changes in carotid body blood flow, increased synaptic density of sensory innervation on type-I cells, maturation of neurotransmitter or neuromodulator mechanisms, and increased sensitivity of the type-I cell’s ability to respond to oxygen The purpose of this study was to determine if carotid chemoreceptor development is due to increasing sensitivity of the type-I cell response to hypoxia
Publication Year: 1994
Publication Date: 1994-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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