Title: Peroxisome proliferator activated receptors, inflammation, the vasculature and the heart
Abstract: Over the last dozen years since the discovery of the family of transcription factor termed peroxisome proliferator activated receptors (PPAR) [], an impressive number of studies have investigated the characteristics, ligands and functional roles as well as molecular mechanisms of PPARs. Although PPARs were formerly believed to regulate genes involved only in lipid and glucose metabolism, a large number of more recent studies have explored the role of PPARs in cell growth, cell migration as well as in inflammation. The function of PPARs in inflammation was first demonstrated by Devchand et al. [] who showed that pro-inflammatory eicosanoid leukotriene B4 binds to PPARa and induces transcription of genes involved in wand (3-oxidation. In this chapter, we briefly summarize the role of PPARs in inflammation generally, and discuss in greater detail the role of PPARs in the heart. We will discuss molecular, biochemical, physiological and pharmacological roles of PPARa and PPARy in the regulation of cardiac hypertrophy, inflammation and cardiac function, and introduce novel concepts relating to PPARs as transcription factors in the regulation of the expression of inflammatory response genes as mechanisms that participate in the pathophysiology of cardiac disease.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot