Title: [57] Coenzyme Q and analogs for coenzymic activity
Abstract: This chapter focuses on the coenzyme Q and the analogs for coenzymic activity. The form of coenzyme Q in human tissue is coenzyme Q10. Many mammalian species also contain coenzyme Q10 (CoQ10), but some rodents such as rats and mice may contain both coenzymes Q9 and Q10 (VII). In nature, coenzymes Q1 through Q10 exist, but coenzymes Q1, Q2, Q3, and Q4 exist in “microtrace” concentrations and were identified by high-sensitivity mass spectrometry in chromatgraphically “pure samples” of the dominant coenzyme Q of diverse organisms. The lipoidal nature of the analogs permits simulation of the intrinsic CoQ10 for both coenzymic activity and for inhibition. However, a form or analog of CoQ10 with negligible or minimal lipoidal character, and an assay system that is not responsive to the lipoidal analogs and forms of CoQ, can give very useful biochemical information. Such information may or may not bear directly on the intrinsic role of the dominant form of CoQ in the given species—for example, CoQ6 or Q7 in yeast, CoQ8 in E. coli, CoQ10 in mammalian mitochondria, etc.
Publication Year: 1978
Publication Date: 1978-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 24
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