Abstract: This chapter discusses the molecular computing with deoxyribozymes. Silicomimetic molecular computing is based on an idea that individual molecules can perform basic logical operations and make simple decisions based on the presence or absence of multiple factors in solution. Using deoxyribozymes, nucleic acid catalysts made of DNA, and recognition regions for oligonucleotides—stem-loops—a so-called “full set of molecular logic gates,” was constructed in the study described in the chapter, which allowed for the combination of individual gates into more complex circuits. These gates and their circuits analyze the sets of oligonucleotides as inputs and produce changed substrate oligonucleotides as outputs. The chapter describes the initial efforts to integrate molecular computing devices with more traditional approaches to nanomedicine, such as those using nanoparticles for drug-delivery. This approach opens possibilities to increase the functional complexity of delivery systems. A three-layer cascade is described, in which microscopic particles coordinate their activity without any direct physical contact. The elementary unit of a network of microparticles is a single particle covered with a DNA computing or sensing element. Individual bead senses the presence of an input stimulus (or multiple stimuli) in solution, and, according to a set of rules encoded on this bead by computing elements, it releases an oligonucleotide signal as an output through a catalytic process.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 31
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