Title: PRION PROTEIN GLYCOFORMS FROM BSE CASES IN POLAND
Abstract: The article describes the analysis of proteinase K resistant prion protein from Polish cases of bovine spongiform encephalopathy (BSE). Brainstem samples from 12 out of 14 cases of BSE diagnosed so far in Poland have been used in the study. Glycotyping showed comparable molecular sizes of three glycoforms in all cases and typical for BSE predominance of diglycosylated form of PrP res in 11 samples. In one case equivalent relative amounts of both di- and monoglycosylated forms of prion protein were detected. The results were compared with both human and other animal TSEs glycotyping studies of PrP res and the reference was made to the possibility of existence of BSE strains on the basis of characteristic glycoforms of PrP res .
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 12
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot