Title: [46] Experimental determination of rates of concerted evolution
Abstract: Members of a repeated gene family within a given species tend to be very similar in DNA sequence, whereas comparable families of repeated sequences (for example, ribosomal RNA genes) are not well conserved between closely related species. This observation indicates that organisms possess mechanisms that conserve sequence homogeneity within a family of repeated genes, a phenomenon termed concerted evolution. This chapter discusses two mechanisms that contribute to concerted evolution and are related to homologous recombination. Gene conversion events involving regions of DNA sequence similarity located at equivalent positions on homologous chromosomes are called “classical” gene conversion events. All eukaryotes thus far examined, however, contain repeated genes, thus affording the opportunity for other types of recombination events involving homologous sequences at nonidentical genomic locations. The chapter also explains the construction of yeast strains containing artificial gene duplications.
Publication Year: 1993
Publication Date: 1993-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 20
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