Title: Su1835 Regulation of Epithelial Mesenchymal Transition Through Protein Kinase CK2 in Helicobacter pylori Infected Gastric Cancer Cells
Abstract: The association between external beam radiation and later development of colorectal cancer (CRC) remains controversial.We reported (DDW 2011) the incidence of CRC for each fiscal year (FY) before diagnosis, from diagnosis to 5 years of follow-up, and after follow-up in irradiated and non-irradiated prostate cancer patients from the VHA National Database (VHAND) to determine a basis for suggested early screening for CRC within 5 years of irradiation.We confirmed a significant increase of CRC in irradiated patients.The overall proportion of CRC in the irradiation group (1,635/24,706) was greater (15,846/442,238) than the non-irradiation group (RR1.76;CI1.68-1.85;p<0.0001).In the current study, we aimed to determine whether this association varies across different racial groups.Methods: We interrogated the VHAND using relevant ICD-9 and CPT codes to identify all patients with a diagnosis of prostate cancer who either were destined to receive irradiation (i.e., irradiation group) or never received irradiation (i.e., no irradiation group) for the period of FY 1999 to FY 2006.We then calculated the relative risk of developing CRC between the irradiation group and the no irradiation group stratified by racial groups.Results The relative risk of developing colorectal cancer between the irradiation group and the no irradiation group within each racial group is shown in the following table: Conclusions: The increase in CRC risk associated with being destined to receive irradiation is much more pronounced among African Americans and Hispanics compared to Caucasians and other racial groups.Future studies should be conducted to define the underlying reasons to explain this phenomenon * no irradiation group as the reference group; Cl-Confidence Intervals Su1832 Cetuximab and Panitumumab Do Not Inhibit Reg4-CD44-Mediated Activation of EGFR in Colorectal Cancer Cells