Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1179025270', 'doi': 'https://doi.org/10.1097/iae.0000000000000664', 'title': 'CONVERSION TO AFLIBERCEPT THERAPY VERSUS CONTINUING WITH RANIBIZUMAB THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION DEPENDENT ON MONTHLY RANIBIZUMAB TREATMENT', 'display_name': 'CONVERSION TO AFLIBERCEPT THERAPY VERSUS CONTINUING WITH RANIBIZUMAB THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION DEPENDENT ON MONTHLY RANIBIZUMAB TREATMENT', 'publication_year': 2015, 'publication_date': '2015-07-11', 'ids': {'openalex': 'https://openalex.org/W1179025270', 'doi': 'https://doi.org/10.1097/iae.0000000000000664', 'mag': '1179025270', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26166797'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/iae.0000000000000664', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S19572933', 'display_name': 'Retina', 'issn_l': '0275-004X', 'issn': ['0275-004X', '1539-2864'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020750527', 'display_name': 'Irmela Mantel', 'orcid': 'https://orcid.org/0000-0002-8822-8194'}, 'institutions': [{'id': 'https://openalex.org/I97565354', 'display_name': 'University of Lausanne', 'ror': 'https://ror.org/019whta54', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I97565354']}, {'id': 'https://openalex.org/I4210124413', 'display_name': 'Fondation Asile des Aveugles', 'ror': 'https://ror.org/03821ge86', 'country_code': 'CH', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210124413']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Irmela Mantel', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland', 'Medical Retina Clinic, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I97565354']}, {'raw_affiliation_string': 'Medical Retina Clinic, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.', 'institution_ids': ['https://openalex.org/I4210124413']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061223836', 'display_name': 'Christina Gianniou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97565354', 'display_name': 'University of Lausanne', 'ror': 'https://ror.org/019whta54', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I97565354']}, {'id': 'https://openalex.org/I4210124413', 'display_name': 'Fondation Asile des Aveugles', 'ror': 'https://ror.org/03821ge86', 'country_code': 'CH', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210124413']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Christina Gianniou', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland', 'Medical Retina Clinic, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I97565354']}, {'raw_affiliation_string': 'Medical Retina Clinic, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.', 'institution_ids': ['https://openalex.org/I4210124413']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048711430', 'display_name': 'Ali Dirani', 'orcid': 'https://orcid.org/0000-0003-2013-5538'}, 'institutions': [{'id': 'https://openalex.org/I97565354', 'display_name': 'University of Lausanne', 'ror': 'https://ror.org/019whta54', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I97565354']}, {'id': 'https://openalex.org/I4210124413', 'display_name': 'Fondation Asile des Aveugles', 'ror': 'https://ror.org/03821ge86', 'country_code': 'CH', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210124413']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Ali Dirani', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland', 'Medical Retina Clinic, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I97565354']}, {'raw_affiliation_string': 'Medical Retina Clinic, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.', 'institution_ids': ['https://openalex.org/I4210124413']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5020750527', 'https://openalex.org/A5061223836', 'https://openalex.org/A5048711430'], 'corresponding_institution_ids': ['https://openalex.org/I97565354', 'https://openalex.org/I4210124413', 'https://openalex.org/I97565354', 'https://openalex.org/I4210124413', 'https://openalex.org/I97565354', 'https://openalex.org/I4210124413'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.37, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.862042, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '36', 'issue': '1', 'first_page': '53', 'last_page': '58'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10170', 'display_name': 'Retinal Diseases and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10170', 'display_name': 'Retinal Diseases and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10993', 'display_name': 'Complement system in diseases', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11438', 'display_name': 'Retinal Imaging and Analysis', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aflibercept', 'display_name': 'Aflibercept', 'score': 0.96478}], 'concepts': [{'id': 'https://openalex.org/C2781100027', 'wikidata': 'https://www.wikidata.org/wiki/Q414270', 'display_name': 'Ranibizumab', 'level': 4, 'score': 0.99158955}, {'id': 'https://openalex.org/C2778749236', 'wikidata': 'https://www.wikidata.org/wiki/Q4689286', 'display_name': 'Aflibercept', 'level': 4, 'score': 0.96478}, {'id': 'https://openalex.org/C2776403814', 'wikidata': 'https://www.wikidata.org/wiki/Q27429789', 'display_name': 'Macular degeneration', 'level': 2, 'score': 0.92579895}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9111283}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.60297585}, {'id': 'https://openalex.org/C2778257484', 'wikidata': 'https://www.wikidata.org/wiki/Q555066', 'display_name': 'Visual acuity', 'level': 2, 'score': 0.54669136}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.47639504}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.26965547}, {'id': 'https://openalex.org/C2777802072', 'wikidata': 'https://www.wikidata.org/wiki/Q413299', 'display_name': 'Bevacizumab', 'level': 3, 'score': 0.23207551}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.10962054}], 'mesh': [{'descriptor_ui': 'D057915', 'descriptor_name': 'Drug Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D040262', 'descriptor_name': 'Receptors, Vascular Endothelial Growth Factor', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005451', 'descriptor_name': 'Fluorescein Angiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058449', 'descriptor_name': 'Intravitreal Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040262', 'descriptor_name': 'Receptors, Vascular Endothelial Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019233', 'descriptor_name': 'Retreatment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D041623', 'descriptor_name': 'Tomography, Optical Coherence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/iae.0000000000000664', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S19572933', 'display_name': 'Retina', 'issn_l': '0275-004X', 'issn': ['0275-004X', '1539-2864'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26166797', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W115097612', 'https://openalex.org/W1481978003', 'https://openalex.org/W1500728559', 'https://openalex.org/W1964901573', 'https://openalex.org/W1968189763', 'https://openalex.org/W1976005612', 'https://openalex.org/W1987259861', 'https://openalex.org/W1990235424', 'https://openalex.org/W2000954383', 'https://openalex.org/W2011187017', 'https://openalex.org/W2032203134', 'https://openalex.org/W2052102026', 'https://openalex.org/W2052840162', 'https://openalex.org/W2053265010', 'https://openalex.org/W2063620836', 'https://openalex.org/W2068742492', 'https://openalex.org/W2081645048', 'https://openalex.org/W2084462826', 'https://openalex.org/W2085712747', 'https://openalex.org/W2093044616', 'https://openalex.org/W2114441193', 'https://openalex.org/W2118192805', 'https://openalex.org/W2120174372', 'https://openalex.org/W2122838150', 'https://openalex.org/W2124415048', 'https://openalex.org/W2128943765', 'https://openalex.org/W2143874967', 'https://openalex.org/W2154711032', 'https://openalex.org/W4248008967', 'https://openalex.org/W4250031098'], 'related_works': ['https://openalex.org/W4388448995', 'https://openalex.org/W3203955741', 'https://openalex.org/W2941660592', 'https://openalex.org/W2883175396', 'https://openalex.org/W2605993654', 'https://openalex.org/W2237198389', 'https://openalex.org/W2131412691', 'https://openalex.org/W2085743381', 'https://openalex.org/W2036910617', 'https://openalex.org/W1663750035'], 'abstract_inverted_index': {'In': [0], 'Brief': [1], 'Purpose:': [2], 'To': [3], 'compare': [4], 'the': [5, 32, 66, 117, 143, 195, 236], 'effects': [6, 196], 'of': [7, 68, 93, 97, 197, 222, 232], 'converting': [8], 'to': [9, 74, 80, 82, 124, 176, 188, 200], 'aflibercept': [10, 83, 180, 201], 'therapy': [11, 15, 78], 'with': [12, 18, 54, 151, 169, 204, 208], 'continuing': [13, 203], 'ranibizumab': [14, 25, 55, 77, 170, 178, 205], 'in': [16, 39, 101, 142, 173, 206, 235], 'eyes': [17, 121, 129], 'neovascular': [19, 50, 162, 209], 'age-related': [20, 51, 163, 210], 'macular': [21, 52, 164, 211], 'degeneration': [22, 53, 165, 212], 'requiring': [23, 166, 213], 'monthly': [24, 63, 167, 214], 'treatment.': [26, 181], 'Methods:': [27], 'Patients': [28, 59], 'were': [29, 72, 122, 134, 140], 'selected': [30], 'from': [31], '104': [33], 'patients': [34, 113, 207], '(115': [35], 'eyes)': [36, 115], 'already': [37], 'enrolled': [38], 'an': [40, 226], '“Observe': [41], 'and': [42, 99, 127, 179, 225], 'Plan”': [43], 'prospective': [44], 'case': [45], 'series': [46], 'that': [47, 161], 'included': [48, 87], 'treating': [49], 'for': [56, 136], '24': [57], 'months.': [58], 'who': [60], 'still': [61], 'needed': [62, 187], 'retreatment': [64, 168, 228], 'at': [65], 'end': [67], 'a': [69, 147, 219], '2-year': [70], 'study': [71, 149, 159, 220], 'randomized': [73, 123], 'either': [75], 'continue': [76], 'or': [79], 'convert': [81], 'therapy.': [84], 'Outcome': [85], 'measures': [86], 'average': [88], 'interval': [89], 'between': [90], 'treatments,': [91], 'resolution': [92], 'exudative': [94], 'signs,': [95], 'number': [96], 'retreatments,': [98], 'change': [100], 'visual': [102], 'acuity': [103], 'over': [104, 146], '12': [105, 223], 'months': [106], '(the': [107], 'third': [108], 'treatment': [109, 199], 'year).': [110], 'Results:': [111], 'Nineteen': [112], '(21': [114], 'met': [116], 'inclusion': [118], 'criteria.': [119], 'Ten': [120], 'receive': [125], 'aflibercept,': [126], '11': [128], 'remained': [130], 'on': [131], 'ranibizumab.': [132], 'Groups': [133], 'balanced': [135], 'baseline': [137, 217], 'characteristics.': [138], 'Outcomes': [139], 'similar': [141, 174, 233], '2': [144, 237], 'groups': [145], '12-month': [148], 'duration,': [150], 'no': [152], 'statistical': [153], 'difference.': [154], 'Conclusion:': [155], 'This': [156], 'comparative': [157], 'pilot': [158], 'suggests': [160], 'may': [171], 'respond': [172], 'ways': [175], 'both': [177], 'Larger': [182], 'sample': [183], 'sizes': [184], 'would': [185], 'be': [186], 'confirm': [189], 'this': [190], 'observation.': [191], 'We': [192], 'prospectively': [193], 'compared': [194], 'changing': [198], 'versus': [202], 'retreatment.': [215], 'Identical': [216], 'times,': [218], 'duration': [221], 'months,': [224], 'interval-based': [227], 'regimen': [229], 'enabled': [230], 'identification': [231], 'responses': [234], 'groups.': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1179025270', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-08T20:48:20.354892', 'created_date': '2016-06-24'}