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{'id': 'https://openalex.org/W1154461499', 'doi': 'https://doi.org/10.1016/j.juro.2015.08.087', 'title': 'Outcomes of Active Surveillance for Clinically Localized Prostate Cancer in the Prospective, Multi-Institutional Canary PASS Cohort', 'display_name': 'Outcomes of Active Surveillance for Clinically Localized Prostate Cancer in the Prospective, Multi-Institutional Canary PASS Cohort', 'publication_year': 2015, 'publication_date': '2015-08-29', 'ids': {'openalex': 'https://openalex.org/W1154461499', 'doi': 'https://doi.org/10.1016/j.juro.2015.08.087', 'mag': '1154461499', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26327354', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4970462'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2015.08.087', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4970462?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102807550', 'display_name': 'Lisa F. 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2545, 2574, 2576, 2626, 2628], 'Antonio,': [135, 137, 311, 313, 2214, 2216, 2575, 2577], 'BoyerHilary': [142], 'Boyer': [144, 1607, 2235], 'BrooksJames': [155], 'Brooks': [157, 1432, 1537, 1609, 1668, 1917, 2261], 'Stanford': [158, 2262], 'University,': [159, 2263], 'Stanford,': [160, 2264], 'California': [161, 170, 175, 184, 189, 291, 296, 334, 339, 2265, 2287, 2292, 2314, 2319, 2542, 2547, 2625, 2630], 'CarrollPeter': [165], 'Carroll': [167, 1434, 1539, 1611, 1670, 1735, 1780, 1919, 2284], 'Francisco,': [172, 174, 186, 188, 293, 295, 336, 338, 2289, 2291, 2316, 2318, 2544, 2546, 2627, 2629], 'CooperbergMatthew': [179], 'Cooperberg': [181, 1541, 1613, 1728, 1777, 2311], 'DashAtreya': [192], 'Dash': [193, 1436, 1543, 1672, 2337], 'Veterans': [194, 399, 475, 2338, 2771, 2913], 'Affairs': [195, 400, 476, 2339, 2772, 2914], 'Puget': [196, 401, 477, 2340, 2773, 2915], 'Sound': [197, 402, 478, 2341, 2774, 2916], 'Care': [199, 404, 480, 1502, 2343, 2776, 2918], 'System,': [200, 405, 481, 2344, 2777, 2919], 'EllisWilliam': [206], 'Ellis': [208, 1615, 1674, 1911, 2365], 'FazliLadan': [216], 'Fazli': [217, 2388], 'British': [220, 223, 245, 248, 346, 349, 2391, 2394, 2443, 2446, 2651, 2654], 'Columbia,': [221, 224, 246, 249, 347, 350, 2392, 2395, 2444, 2447, 2652, 2655], 'Vancouver,': [222, 247, 348, 2393, 2445, 2653], 'Canada': [225, 250, 351, 2396, 2448, 2656], 'FengZiding': [228], 'Feng': [229, 2414], 'GleaveMartin': [240], 'Gleave': [242, 1440, 1547, 1617, 1678, 1921, 2440], 'KunjuPriya': [253], 'Kunju': [254, 2466], 'Michigan,': [257, 429, 2469, 2827], 'Ann': [258, 430, 940, 2470, 2828], 'Arbor,': [259, 431, 2471, 2829], 'Michigan': [260, 432, 2472, 2830], 'LanceRaymond': [264], 'Lance': [266, 1923, 2491], 'Eastern': [267, 369, 2492, 2700], 'Virginia': [268, 272, 370, 374, 2493, 2497, 2701, 2705], 'Medical': [269, 324, 371, 417, 2494, 2601, 2702, 2802], 'School,': [270, 372, 2495, 2703], 'Norfolk,': [271, 373, 2496, 2704], 'McKenneyJesse': [276], 'McKenney': [278, 1430, 2516], 'Cleveland': [279, 2517], 'Clinic,': [280, 2518], 'Cleveland,': [281, 2519], 'Ohio': [282, 2520], 'MengMaxwell': [286], 'Meng': [288, 2539], 'NicolasMarlo': [300], 'Nicolas': [302, 2566], 'SandaMartin': [318], 'Sanda': [320, 2597], 'Beth': [321, 414, 2598, 2799], 'Israel': [322, 415, 2599, 2800], 'Deaconess': [323, 416, 2600, 2801], 'Boston,': [326, 419, 2603, 2804], 'Massachusetts': [327, 420, 2604, 2805], 'SimkoJeffry': [330], 'Simko': [331, 2622], 'SoAlan': [342], 'So': [343, 2648], 'TretiakovaMaria': [355], 'Tretiakova': [357, 2675], 'TroyerDean': [366], 'Troyer': [368, 2699], 'TrueLawrence': [378], 'True': [380, 2724], 'Vakar-LopezFunda': [388], 'Vakar-Lopez': [389, 2747], 'VirginJeff': [397], 'Virgin': [398, 2770], 'WagnerAndrew': [411], 'Wagner': [413, 1453, 1559, 1625, 1686, 1929, 2798], 'WeiJohn': [424], 'Wei': [426, 1931, 2824], 'ZhengYingye': [435], 'Zheng': [436, 1424, 1529, 1601, 1688, 1915, 2848], 'NelsonPeter': [447], 'Nelson': [449, 1448, 1555, 1623, 1682, 1925, 2874], 'LinDaniel': [460], 'Lin': [462, 1386, 1450, 1562, 1630, 1691, 1934, 2900], 'View': [489], 'All': [490, 2947], 'Author': [491], 'Informationhttps://doi.org/10.1016/j.juro.2015.08.087AboutFull': [492], 'TextPDF': [493], 'ToolsAdd': [494], 'to': [495, 508, 801], 'favoritesDownload': [496], 'CitationsTrack': [497], 'CitationsPermissionsReprints': [498], 'ShareFacebookLinked': [499], 'InTwitterEmail': [500], 'Abstract': [501], 'Purpose:': [502], 'surveillance': [504, 723, 877, 950, 974, 991, 1013, 1197, 1335], 'represents': [505], 'a': [506, 522, 528, 598, 605, 740, 874, 958, 971, 1175, 1201, 1316, 1339, 1513, 1785, 1851], 'strategy': [507], 'address': [509], 'overtreatment': [511], 'prostate': [513, 663, 769, 788, 808, 827, 851, 931, 955, 979, 994, 1016, 1087, 1101, 1112, 1141, 1146, 1199, 1221, 1246, 1285, 1310, 1364], 'cancer,': [514, 658, 915], 'yet': [515], 'uncertainty': [516], 'regarding': [517], 'individual': [518], 'patient': [519], 'outcomes': [520, 526, 762], 'remains': [521], 'concern.': [523], 'We': [524, 538, 552, 581], 'evaluated': [525, 583], 'prospective': [529, 544], 'multicenter': [530], 'study': [531, 557], 'active': [533, 601, 626, 722, 876, 973, 1314, 1334], 'surveillance.': [534, 602, 627], 'Materials': [535, 2154], 'Methods:': [537], 'studied': [539], '905': [540], 'men': [541, 719, 848, 1306], 'enrolled': [547], 'between': [548, 707], '2008': [549], '2013.': [551], 'collected': [553], 'clinical': [554, 587, 736, 1066], 'data': [555], 'entry': [558], 'prespecified': [561], 'intervals,': [562], 'determined': [564], 'associations': [565], 'with': [566, 589, 635, 657, 669, 681, 699, 703, 743, 849, 978, 1105, 1279, 1307, 1571, 1847, 1896, 2094, 2111, 2135, 2194, 2223, 2250, 2273, 2300, 2327, 2354, 2378, 2404, 2429, 2456, 2480, 2505, 2528, 2555, 2586, 2612, 2638, 2664, 2688, 2713, 2737, 2760, 2787, 2813, 2838, 2863, 2889, 2929], 'adverse': [567, 615, 636, 670, 686, 728, 731], 'reclassification,': [568, 616, 637, 745], 'defined': [569, 688], 'as': [570, 689, 1850, 1974], 'increased': [571], 'Gleason': [572, 899, 1244, 1303], 'grade': [573], 'or': [574, 693, 730, 2108, 2189, 2245, 2268, 2295, 2322, 2349, 2373, 2399, 2424, 2451, 2475, 2500, 2523, 2550, 2581, 2607, 2633, 2659, 2683, 2708, 2732, 2755, 2782, 2808, 2833, 2858, 2884, 2924], 'greater': [575], 'cancer': [576, 809, 852, 956, 1017, 1106, 1222, 1311], 'volume': [577, 1259], 'on': [578, 625, 721, 898, 1140, 1505, 1795, 1943], 'followup': [579, 607], 'biopsy.': [580], 'also': [582], 'relationships': [585], 'parameters': [588], 'pathology': [590, 732], 'findings': [591, 713], 'participants': [593, 613, 631, 678], 'who': [594], 'underwent': [595, 620], 'surgery': [596, 715], 'after': [597, 1045, 1184, 1698, 1749, 1888, 2056], 'period': [599], 'Results:': [603], 'At': [604], 'median': [606], '28': [609], 'months': [610], '24%': [611], 'experienced': [614], 'whom': [618], '53%': [619], 'treatment': [621, 642, 785], 'while': [622, 638], '31%': [623], 'continued': [624], 'Overall': [628], '19%': [629], 'received': [632], 'treatment,': [633], '68%': [634], '32%': [639], 'opted': [640], 'without': [643, 727], 'disease': [644, 744, 1081, 1182], 'reclassification.': [645], 'In': [646], 'multivariate': [647], 'Cox': [648], 'proportional': [649], 'hazards': [650], 'modeling': [651], 'percent': [653], 'biopsy': [655, 1103, 1143, 1265], 'cores': [656, 1104], 'body': [659], 'mass': [660], 'index': [661], 'specific': [664, 1113, 1147], 'antigen': [665, 803, 1114, 1148], 'density': [666], 'were': [667], 'associated': [668, 1278, 2193, 2249, 2272, 2299, 2326, 2353, 2377, 2403, 2428, 2455, 2479, 2504, 2527, 2554, 2585, 2611, 2637, 2663, 2687, 2712, 2736, 2759, 2786, 2812, 2837, 2862, 2888, 2928], 'reclassification': [671, 729], '(p=0.01,': [672], '0.04,': [673, 674], 'respectively).': [675], 'Of': [676], '103': [677], 'subsequently': [679], 'treated': [680], 'radical': [682, 1046, 1084, 1117, 1185, 1261], 'prostatectomy': [683, 1085, 1262, 1359], '34%': [684], 'had': [685, 738], 'pathology,': [687, 1144], 'primary': [690, 784], 'pattern': [691], '4-5': [692], 'nonorgan': [694], 'confined': [695], 'disease,': [696], 'including': [697], '2': [698, 776, 1465], 'positive': [700], 'lymph': [701], 'nodes,': [702], 'no': [704, 1848], 'significant': [705, 1108], 'relationship': [706, 2222], 'risk': [708, 826, 829, 1241, 1280], 'category': [709], 'diagnosis': [711], '(p=0.76).': [716], 'Conclusions:': [717], 'Most': [718], 'remain': [720], '5': [725, 840], 'years': [726], 'surgery.': [734], 'However,': [735], 'factors': [737], 'only': [739], 'modest': [741], 'association': [742], 'supporting': [746], 'need': [748], 'approaches': [750], 'that': [751], 'improve': [752], 'prediction': [754, 1042], 'this': [756, 2196, 2201, 2231, 2252, 2257, 2275, 2280, 2302, 2307, 2329, 2334, 2356, 2361, 2380, 2385, 2406, 2411, 2431, 2436, 2458, 2463, 2482, 2487, 2507, 2512, 2530, 2535, 2557, 2562, 2588, 2593, 2614, 2619, 2640, 2645, 2666, 2671, 2690, 2695, 2715, 2720, 2739, 2744, 2762, 2767, 2789, 2794, 2815, 2820, 2840, 2845, 2865, 2870, 2891, 2896, 2931, 2936, 2944], 'outcome.': [757, 1223], 'References': [758], '1': [759], ':': [760, 777, 798, 821, 841, 866, 887, 913, 928, 948, 967, 989, 1011, 1029, 1054, 1076, 1098, 1130, 1161, 1195, 1214, 1233, 1254, 1275, 1296, 1327, 1357], '20-Year': [761], 'following': [763, 1083, 1116], 'conservative': [764], 'management': [765, 953], 'clinically': [767], 'localized': [768, 787, 1363], 'cancer.': [770, 789, 980, 1088, 1247, 1365], 'JAMA2005;': [771], '293:': [772], '2095.': [773], 'Google': [774, 795, 818, 838, 863, 884, 910, 925, 945, 964, 986, 1008, 1026, 1051, 1073, 1095, 1127, 1158, 1192, 1211, 1230, 1251, 1272, 1293, 1324, 1354, 1372], 'Scholar': [775, 796, 819, 839, 864, 885, 911, 926, 946, 965, 987, 1009, 1027, 1052, 1074, 1096, 1128, 1159, 1193, 1212, 1231, 1252, 1273, 1294, 1325, 1355, 1373], 'Time': [778], 'trends': [779, 823], 'local': [781, 845], 'variation': [782], 'J': [790, 812, 833, 857, 905, 918, 981, 1003, 1068, 1089, 1123, 1153, 1187, 1224, 1267, 1319, 1368, 1881, 1884, 1932, 1996], 'Clin': [791, 982, 1004, 1349], 'Oncol2010;': [792], '28:': [793], '1117.': [794], '3': [797, 1988], 'Overdiagnosis': [799], 'due': [800], 'prostate-specific': [802], 'screening:': [804], 'lessons': [805], 'from': [806, 1120, 1338, 1470, 1579, 1857, 1948, 2099, 2105], 'U.S.': [807, 933], 'incidence': [810], 'trends.': [811], 'Natl': [813, 858, 919, 1090, 1225], 'Inst2002;': [815], '94:': [816], '981.': [817], '4': [820], 'Contemporary': [822], 'low': [825], 'cancer:': [828, 932, 995, 1200], 'assessment': [830], 'treatment.': [832], 'Urol2007;': [834], '178:': [835], 'S14.': [836], 'Link,': [837, 1157, 1191, 1271, 1323], 'Incidence': [842], 'initial': [844], 'therapy': [846], 'among': [847], 'lower-risk': [850], 'United': [855], 'States.': [856], 'Inst2006;': [860, 1227], '98:': [861, 1228], '1134.': [862], '6': [865, 1245], 'Study:': [871], 'design': [872], 'multi-institutional': [875, 1236, 1317], 'cohort': [878, 975], 'biorepository.': [880], 'Urology2010;': [881], '75:': [882], '407.': [883], '7': [886], 'The': [888, 1162, 1297], '2005': [889], 'International': [890], 'Society': [891], 'Urological': [893, 1378, 2162], 'Pathology': [894], '(ISUP)': [895], 'Consensus': [896], 'Conference': [897], 'Grading': [900], 'Prostatic': [902], 'Carcinoma.': [903], 'Am': [904], 'Surg': [906], 'Pathol2005;': [907], '29:': [908, 1006], '1228.': [909], '8': [912], 'version': [916], '1.2014.': [917], 'Compr': [920], 'Canc': [921], 'Netw2013;': [922], '11:': [923], '1471.': [924], '9': [927], 'Screening': [929], 'Preventive': [934], 'Services': [935], 'Task': [936], 'Force': [937], 'recommendation': [938], 'statement.': [939], 'Intern': [941], 'Med2012;': [942, 1369], '157:': [943], '120.': [944], '10': [947], 'contemporary': [959], 'cohort.': [960], 'Cancer2008;': [961], '112:': [962], '2664.': [963], '11': [966], 'Long-term': [968], 'follow-up': [969], 'large': [972], 'patients': [977], 'Oncol2015;': [983], '33:': [984], '272.': [985], '12': [988], 'program': [992], 'an': [996, 1239, 1333, 1750, 1975], 'update': [997], 'Johns': [1000], 'Hopkins': [1001], 'experience.': [1002], 'Oncol2011;': [1005], '2185.': [1007], '13': [1010], 'low-risk': [1015, 1284], 'worldwide:': [1018], 'PRIAS': [1020], 'study.': [1021, 1318], 'Eur': [1022, 1207, 1289], 'Urol2013;': [1023], '63:': [1024], '597.': [1025], '14': [1028], 'Multiinstitutional': [1030], 'validation': [1031, 1237], 'UCSF': [1034], 'Risk': [1039, 1172, 1507, 1572, 1704, 1972, 2053, 2061, 2096], 'Assessment': [1040, 1173], 'recurrence': [1044, 1082, 1115, 1183], 'prostatectomy.': [1047, 1186], 'Cancer2006;': [1048], '107:': [1049], '2384.': [1050], '15': [1053], 'Prediction': [1055, 1131], 'prognosis': [1057], 'prostatic': [1059], 'adenocarcinoma': [1060], 'by': [1061, 1313, 1376, 2160, 2200, 2230, 2256, 2279, 2306, 2333, 2360, 2384, 2410, 2435, 2462, 2486, 2511, 2534, 2561, 2592, 2618, 2644, 2670, 2694, 2719, 2743, 2766, 2793, 2819, 2844, 2869, 2895, 2935, 2943], 'combined': [1062], 'histological': [1063], 'grading': [1064, 1304], 'staging.': [1067], 'Urol1974;': [1069], '111:': [1070], '58.': [1071], 'Abstract,': [1072], '16': [1075], 'A': [1077, 1454, 1560], 'preoperative': [1078, 1179], 'nomogram': [1079], 'Inst1998;': [1092], '90:': [1093], '766.': [1094], '17': [1097], 'Percent': [1099], 'needle': [1102, 1142, 1264], 'is': [1107, 1277, 1568], 'independent': [1109], 'predictor': [1110, 1180], 'prostatectomy:': [1118], 'results': [1119, 1337], 'SEARCH': [1121], 'database.': [1122], 'Urol2003;': [1124], '169:': [1125], '2136.': [1126], '18': [1129], 'extraprostatic': [1133], 'extension': [1134], 'neurovascular': [1137], 'bundle': [1138], 'based': [1139], 'serum': [1145], 'digital': [1150], 'rectal': [1151], 'examination.': [1152], 'Urol2005;': [1154, 1188], '173:': [1155, 1189], '450.': [1156], '19': [1160], 'California,': [1165], 'Francisco': [1167], 'score:': [1174], 'straightforward': [1176], 'reliable': [1178], '1938.': [1190], '20': [1194], 'systematic': [1202], 'review': [1203], 'literature.': [1206], 'Urol2012;': [1208], '62:': [1209], '976.': [1210], '21': [1213], 'Delayed': [1215, 2112], 'versus': [1216, 1360], 'immediate': [1217], 'surgical': [1218], 'intervention': [1219], '355.': [1229], '22': [1232], 'Development': [1234], 'upgrading': [1240], 'tool': [1242], 'Cancer2013;': [1248], '119:': [1249], '3992.': [1250], '23': [1253], 'Prognostic': [1255, 1852], 'significance': [1256], 'tumor': [1258], 'specimens.': [1266], 'Urol2011;': [1268, 1320], '186:': [1269, 1321], '790.': [1270], '24': [1274], 'Obesity': [1276], 'progression': [1282], 'cancers': [1286], 'managed': [1287, 1312], 'expectantly.': [1288], 'Urol2014;': [1290], '66:': [1291], '841.': [1292], '25': [1295], 'potential': [1298], 'impact': [1299], 'reproducibility': [1301], 'early': [1308], 'stage': [1309], 'surveillance:': [1315], '465.': [1322], '26': [1326], 'Urinary': [1328], 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