Title: Preparation and characterization of interpenetrating hydrogel for colon drug delivery
Abstract: This thesis work is based on preparation and characterization of Interpenetrating (IPN) hydrogels of poly (HEMA) with polysaccharides (xanthan gum or isabgol). IPN hydrogels were prepared by cross-linking the HEMA in the presence of varying concentration of xanthan gum or isabgol. The concentrations of xanthan gum used for this purpose were 0.1% (w/v), 0.3% (w/v),0.5% (w/v) and 0.7% (w/v) whereas the concentrations of isabgol selected were 1% (w/v), 2% (w/v), 3% (w/v) and 4% (w/v). The HEMA and the polysaccharides either xanthan gum or isabgol were mixed in the proportion of 30:70 (w/w) before being croslinked using APS and TEMED. The IPN hydrogels were characterized by swelling tests at Ph 1.2, pH 7 and Ph 9.Physical properties were assessed by XRD and FTIR. Suitability of its application as colon drug delivery system (CDDS) was assessed by incorporating curcumin for in-vitro drug release kinetics assay in the simulated condition of gastrointestinal system. The IPN hydrogels were found to swell maximal at pH 7 and the rate of drug release was found to be highest at pH 6.8 indicating its potential application as CDDS.
Publication Year: 2014
Publication Date: 2014-06-01
Language: en
Type: dissertation
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