Title: The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa.
Abstract: Research Article1 June 1993free access The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa. S. Jones S. Jones Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author B. Yu B. Yu Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author N.J. Bainton N.J. Bainton Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author M. Birdsall M. Birdsall Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author B.W. Bycroft B.W. Bycroft Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author S.R. Chhabra S.R. Chhabra Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author A.J. Cox A.J. Cox Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author P. Golby P. Golby Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author P.J. Reeves P.J. Reeves Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author S. Stephens S. Stephens Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author S. Jones S. Jones Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author B. Yu B. Yu Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author N.J. Bainton N.J. Bainton Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author M. Birdsall M. Birdsall Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author B.W. Bycroft B.W. Bycroft Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author S.R. Chhabra S.R. Chhabra Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author A.J. Cox A.J. Cox Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author P. Golby P. Golby Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author P.J. Reeves P.J. Reeves Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author S. Stephens S. Stephens Department of Biological Sciences, University of Warwick, Coventry, UK. Search for more papers by this author Author Information S. Jones1, B. Yu1, N.J. Bainton1, M. Birdsall1, B.W. Bycroft1, S.R. Chhabra1, A.J. Cox1, P. Golby1, P.J. Reeves1 and S. Stephens1 1Department of Biological Sciences, University of Warwick, Coventry, UK. The EMBO Journal (1993)12:2477-2482https://doi.org/10.1002/j.1460-2075.1993.tb05902.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Erwinia carotovora and Pseudomonas aeruginosa secrete exoenzymes that contribute to the pathogenesis of plant and mammalian infections respectively. E.carotovora mutants defective in synthesis of the pectinase, cellulase and protease exoenzymes were isolated and classified into two groups. Group 2 mutants were found to be defective in the production of a small freely diffusible molecule, N-3-(oxohexanoyl)-L-homoserine, lactone (HSL), and were avirulent. Addition of exogenous HSL to these group 2 mutants restores synthesis of the exoenzymes and virulence in planta. Of the exoenzymes of P.aeruginosa the metalloprotease, elastase, is an established virulence determinant. Mutants of P.aeruginosa that are defective in elastase production have been isolated and were again found to fall into two groups. Analogous to the group 2 mutants of E.carotovora, group 2 mutants of P. aeruginosa are defective in the synthesis of HSL and exogenous HSL restores elastase production. HSL has now been linked to the control of bioluminescence in Vibrio fischeri, carbapenem antibiotic production of E.carotovora and the above exoenzyme virulence determinants. This information significantly enhances our understanding of the extent and nature of pheromone mediated gene expression control in prokaryotes. Previous ArticleNext Article Volume 12Issue 61 June 1993In this issue RelatedDetailsLoading ...