Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W109431680', 'doi': 'https://doi.org/10.1007/978-0-585-37970-8_2', 'title': 'Major Depression and Activation of The Inflammatory Response System', 'display_name': 'Major Depression and Activation of The Inflammatory Response System', 'publication_year': 1999, 'publication_date': '1999-01-01', 'ids': {'openalex': 'https://openalex.org/W109431680', 'doi': 'https://doi.org/10.1007/978-0-585-37970-8_2', 'mag': '109431680', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10442165'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-0-585-37970-8_2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43790123', 'display_name': 'Advances in experimental medicine and biology', 'issn_l': '0065-2598', 'issn': ['0065-2598', '2214-8019'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032880777', 'display_name': 'Michaël Maes', 'orcid': 'https://orcid.org/0000-0002-2012-871X'}, 'institutions': [], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Michael Maes', 'raw_affiliation_strings': ['Clinical Research Center for Mental Health (CRC-MH) Antwerp, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research Center for Mental Health (CRC-MH) Antwerp, Belgium', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5032880777'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.216, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 595, 'citation_normalized_percentile': {'value': 0.925926, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': None, 'issue': None, 'first_page': '25', 'last_page': '46'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11337', 'display_name': 'Neuroimmune Interaction in Psychiatric Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11337', 'display_name': 'Neuroimmune Interaction in Psychiatric Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10529', 'display_name': 'Effects of Stress on Brain Function and Health', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11541', 'display_name': 'Oxytocin and Social Behavior Regulation', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/depression', 'display_name': 'Depression', 'score': 0.549251}, {'id': 'https://openalex.org/keywords/antidepressant-treatment', 'display_name': 'Antidepressant Treatment', 'score': 0.509917}, {'id': 'https://openalex.org/keywords/stress', 'display_name': 'Stress', 'score': 0.50946}], 'concepts': [{'id': 'https://openalex.org/C2776867660', 'wikidata': 'https://www.wikidata.org/wiki/Q1814941', 'display_name': 'Depression (economics)', 'level': 2, 'score': 0.74197423}, {'id': 'https://openalex.org/C2776824294', 'wikidata': 'https://www.wikidata.org/wiki/Q18344428', 'display_name': 'Catecholaminergic', 'level': 3, 'score': 0.5628979}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.51441556}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.46550968}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.43885353}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.42058495}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39726663}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3655301}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.16585907}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.09345186}, {'id': 'https://openalex.org/C165556158', 'wikidata': 'https://www.wikidata.org/wiki/Q83937', 'display_name': 'Keynesian economics', 'level': 1, 'score': 0.053429067}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D003866', 'descriptor_name': 'Depressive Disorder', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000523', 'qualifier_name': 'psychology', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003866', 'descriptor_name': 'Depressive Disorder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003866', 'descriptor_name': 'Depressive Disorder', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009490', 'descriptor_name': 'Neurosecretory Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009490', 'descriptor_name': 'Neurosecretory Systems', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009490', 'descriptor_name': 'Neurosecretory Systems', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-0-585-37970-8_2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43790123', 'display_name': 'Advances in experimental medicine and biology', 'issn_l': '0065-2598', 'issn': ['0065-2598', '2214-8019'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10442165', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.52}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 178, 'referenced_works': ['https://openalex.org/W128592590', 'https://openalex.org/W150428852', 'https://openalex.org/W1531742112', 'https://openalex.org/W1557360794', 'https://openalex.org/W1573943919', 'https://openalex.org/W1586928599', 'https://openalex.org/W1747551678', 'https://openalex.org/W175741237', 'https://openalex.org/W1792389655', 'https://openalex.org/W1825059020', 'https://openalex.org/W1883403773', 'https://openalex.org/W1905885236', 'https://openalex.org/W1942920640', 'https://openalex.org/W1964194283', 'https://openalex.org/W1965127835', 'https://openalex.org/W1965659979', 'https://openalex.org/W1966771363', 'https://openalex.org/W1968718353', 'https://openalex.org/W1969181627', 'https://openalex.org/W1969650068', 'https://openalex.org/W1969726115', 'https://openalex.org/W1970183986', 'https://openalex.org/W1971051809', 'https://openalex.org/W1972352507', 'https://openalex.org/W1973324699', 'https://openalex.org/W1980486417', 'https://openalex.org/W1981277471', 'https://openalex.org/W1982454043', 'https://openalex.org/W1982597476', 'https://openalex.org/W1985419147', 'https://openalex.org/W1987996344', 'https://openalex.org/W1990052364', 'https://openalex.org/W1991226120', 'https://openalex.org/W1993019072', 'https://openalex.org/W1993358990', 'https://openalex.org/W1993622831', 'https://openalex.org/W1993701317', 'https://openalex.org/W1993856151', 'https://openalex.org/W1996019229', 'https://openalex.org/W1996512957', 'https://openalex.org/W1997704590', 'https://openalex.org/W2000679986', 'https://openalex.org/W2000956334', 'https://openalex.org/W2003012131', 'https://openalex.org/W2004634004', 'https://openalex.org/W2004894402', 'https://openalex.org/W2005593139', 'https://openalex.org/W2005903257', 'https://openalex.org/W2006014567', 'https://openalex.org/W2006791697', 'https://openalex.org/W2010145371', 'https://openalex.org/W2012405949', 'https://openalex.org/W2012749311', 'https://openalex.org/W2013278955', 'https://openalex.org/W2017810128', 'https://openalex.org/W2018231700', 'https://openalex.org/W2019324493', 'https://openalex.org/W2019327238', 'https://openalex.org/W2020188308', 'https://openalex.org/W2021723318', 'https://openalex.org/W2022868624', 'https://openalex.org/W2023903089', 'https://openalex.org/W2024711770', 'https://openalex.org/W2025318581', 'https://openalex.org/W2025564422', 'https://openalex.org/W2025960927', 'https://openalex.org/W2026087681', 'https://openalex.org/W2026633588', 'https://openalex.org/W2028694464', 'https://openalex.org/W2029691379', 'https://openalex.org/W2029755823', 'https://openalex.org/W2032657270', 'https://openalex.org/W2034137314', 'https://openalex.org/W2035252904', 'https://openalex.org/W2036062598', 'https://openalex.org/W2038163560', 'https://openalex.org/W2038473038', 'https://openalex.org/W2041291723', 'https://openalex.org/W2041663965', 'https://openalex.org/W2042672223', 'https://openalex.org/W2043652950', 'https://openalex.org/W2043924977', 'https://openalex.org/W2044751773', 'https://openalex.org/W2045076279', 'https://openalex.org/W2045599452', 'https://openalex.org/W2046853358', 'https://openalex.org/W2048431959', 'https://openalex.org/W2048876068', 'https://openalex.org/W2050442674', 'https://openalex.org/W2051052878', 'https://openalex.org/W2052445727', 'https://openalex.org/W2056545367', 'https://openalex.org/W2057325221', 'https://openalex.org/W2058687438', 'https://openalex.org/W2058759125', 'https://openalex.org/W2058978987', 'https://openalex.org/W2060345189', 'https://openalex.org/W2061794524', 'https://openalex.org/W2061828916', 'https://openalex.org/W2062175236', 'https://openalex.org/W2065730420', 'https://openalex.org/W2065806523', 'https://openalex.org/W2066503688', 'https://openalex.org/W2067927862', 'https://openalex.org/W2069272322', 'https://openalex.org/W2072256063', 'https://openalex.org/W2073131735', 'https://openalex.org/W2075840772', 'https://openalex.org/W2076244671', 'https://openalex.org/W2077297850', 'https://openalex.org/W2077794554', 'https://openalex.org/W2079873782', 'https://openalex.org/W2080096327', 'https://openalex.org/W2081966783', 'https://openalex.org/W2082150092', 'https://openalex.org/W2082525306', 'https://openalex.org/W2082675050', 'https://openalex.org/W2083061791', 'https://openalex.org/W2083816898', 'https://openalex.org/W2085036778', 'https://openalex.org/W2085241964', 'https://openalex.org/W2086377599', 'https://openalex.org/W2086437482', 'https://openalex.org/W2086936383', 'https://openalex.org/W2087870123', 'https://openalex.org/W2088383629', 'https://openalex.org/W2090877731', 'https://openalex.org/W2092305254', 'https://openalex.org/W2094035317', 'https://openalex.org/W2094116004', 'https://openalex.org/W2094371219', 'https://openalex.org/W2105368071', 'https://openalex.org/W2112437115', 'https://openalex.org/W2113354422', 'https://openalex.org/W2117978763', 'https://openalex.org/W2123200029', 'https://openalex.org/W2124687910', 'https://openalex.org/W2125460362', 'https://openalex.org/W2128068240', 'https://openalex.org/W2128394628', 'https://openalex.org/W2129909496', 'https://openalex.org/W2135156135', 'https://openalex.org/W2138187317', 'https://openalex.org/W2141528390', 'https://openalex.org/W2142455495', 'https://openalex.org/W2145890122', 'https://openalex.org/W2150896891', 'https://openalex.org/W2151881464', 'https://openalex.org/W2163372524', 'https://openalex.org/W2167097948', 'https://openalex.org/W2168658413', 'https://openalex.org/W2169882565', 'https://openalex.org/W2201663582', 'https://openalex.org/W2232180582', 'https://openalex.org/W2295367859', 'https://openalex.org/W2296293854', 'https://openalex.org/W2319359283', 'https://openalex.org/W2324490452', 'https://openalex.org/W2329315405', 'https://openalex.org/W2358185940', 'https://openalex.org/W2394959487', 'https://openalex.org/W2406246531', 'https://openalex.org/W2406894639', 'https://openalex.org/W2409508723', 'https://openalex.org/W2413432223', 'https://openalex.org/W2416287725', 'https://openalex.org/W2437866302', 'https://openalex.org/W33142977', 'https://openalex.org/W4233711437', 'https://openalex.org/W4233805153', 'https://openalex.org/W4245534321', 'https://openalex.org/W4248530879', 'https://openalex.org/W4255635114', 'https://openalex.org/W4285719527', 'https://openalex.org/W4951227', 'https://openalex.org/W565201097', 'https://openalex.org/W607278967', 'https://openalex.org/W612863614'], 'related_works': ['https://openalex.org/W4283319608', 'https://openalex.org/W2748952813', 'https://openalex.org/W2062053200', 'https://openalex.org/W2036716432', 'https://openalex.org/W2012169650', 'https://openalex.org/W2005371188', 'https://openalex.org/W1965862644', 'https://openalex.org/W1528746761', 'https://openalex.org/W146232312', 'https://openalex.org/W142163214'], 'abstract_inverted_index': {'Contemporary': [0, 29], 'models': [1, 30], 'of': [2, 8, 13, 18, 26, 31, 39, 61, 85, 124], 'major': [3, 27, 32, 77, 125], 'depression': [4, 33, 78], 'emphasize': [5], 'the': [6, 16, 24, 37, 40, 47, 62, 86], 'role': [7], 'hypothalamic-pituitary-adrenal': [9], '(HPA)-axis': [10], 'hyperactivity': [11], 'and': [12, 54, 57, 70], 'dysfunctions': [14], 'in': [15, 23, 68], 'turnover': [17, 56], 'serotonin': [19], '(5-HT)': [20], 'or': [21], 'catecholamines': [22], 'etiopathogenesis': [25], 'depression.': [28, 126], 'do': [34], 'not': [35], 'incorporate': [36], 'effects': [38], 'inflammatory': [41], 'response': [42], 'system': [43], '(IRS),': [44], 'even': [45, 58], 'though': [46, 59], 'IRS': [48, 63, 87, 122], 'powerfully': [49], 'influences': [50], 'HPA-axis': [51], 'activity,': [52], '5-HT': [53], 'catecholaminergic': [55], 'activation': [60, 84], 'may': [64], 'induce': [65], 'depression-like': [66], 'behavior': [67], 'animals': [69], 'humans.': [71], 'There': [72], 'is': [73, 79], 'now': [74], 'evidence': [75], 'that': [76], 'accompanied': [80], 'by': [81], 'a': [82, 120], 'moderate': [83], '(reviews:': [88], 'Maes,': [89, 93], '1993;': [90], '1995;': [91], '1997;': [92, 102, 106], 'Smith,': [94, 105], '&': [95, 100, 104, 108, 112], 'Scharpe,': [96], '1995c;': [97], 'Holden,': [98], 'Pakula,': [99], 'Mooney,': [101], 'Maes': [103], 'Connor': [107], 'Leonard,': [109], '1998;': [110], 'Maier': [111], 'Watkins,': [113], '1998).': [114], 'In': [115], 'this': [116], 'paper': [117], 'we': [118], 'propose': [119], 'concise': [121], 'model': [123]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W109431680', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 28}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 29}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 25}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 29}, {'year': 2012, 'cited_by_count': 28}], 'updated_date': '2024-09-13T08:40:37.645480', 'created_date': '2016-06-24'}