Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1084638677', 'doi': 'https://doi.org/10.1016/j.mcn.2015.08.002', 'title': 'Amyloid-β induced astrocytosis and astrocyte death: Implication of FoxO3a–Bim–caspase3 death signaling', 'display_name': 'Amyloid-β induced astrocytosis and astrocyte death: Implication of FoxO3a–Bim–caspase3 death signaling', 'publication_year': 2015, 'publication_date': '2015-08-08', 'ids': {'openalex': 'https://openalex.org/W1084638677', 'doi': 'https://doi.org/10.1016/j.mcn.2015.08.002', 'mag': '1084638677', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26260111'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mcn.2015.08.002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47891569', 'display_name': 'Molecular and Cellular Neuroscience', 'issn_l': '1044-7431', 'issn': ['1044-7431', '1095-9327'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101975331', 'display_name': 'Pampa Saha', 'orcid': 'https://orcid.org/0000-0002-4926-9081'}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Pampa Saha', 'raw_affiliation_strings': ['Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700 032, India.'], 'affiliations': [{'raw_affiliation_string': 'Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700 032, India.', 'institution_ids': ['https://openalex.org/I160344538']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101719991', 'display_name': 'Subhas C. Biswas', 'orcid': 'https://orcid.org/0000-0002-1746-101X'}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Subhas Chandra Biswas', 'raw_affiliation_strings': ['Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700 032, India. Electronic address: [email protected].'], 'affiliations': [{'raw_affiliation_string': 'Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700 032, India. Electronic address: [email protected].', 'institution_ids': ['https://openalex.org/I160344538']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3570, 'currency': 'USD', 'value_usd': 3570, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.366, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.83076, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '68', 'issue': None, 'first_page': '203', 'last_page': '211'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12835', 'display_name': 'FOXO transcription factor regulation', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/astrocytosis', 'display_name': 'Astrocytosis', 'score': 0.9947685}], 'concepts': [{'id': 'https://openalex.org/C2908656565', 'wikidata': 'https://www.wikidata.org/wiki/Q4811564', 'display_name': 'Astrocytosis', 'level': 3, 'score': 0.9947685}, {'id': 'https://openalex.org/C2777542381', 'wikidata': 'https://www.wikidata.org/wiki/Q502961', 'display_name': 'Astrocyte', 'level': 3, 'score': 0.89321864}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.6683431}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.65740824}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.59097934}, {'id': 'https://openalex.org/C68026918', 'wikidata': 'https://www.wikidata.org/wiki/Q1970256', 'display_name': 'Senile plaques', 'level': 4, 'score': 0.5816412}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.57595044}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.5698592}, {'id': 'https://openalex.org/C2780495277', 'wikidata': 'https://www.wikidata.org/wiki/Q905442', 'display_name': 'Glial fibrillary acidic protein', 'level': 3, 'score': 0.4803418}, {'id': 'https://openalex.org/C2778794669', 'wikidata': 'https://www.wikidata.org/wiki/Q43054', 'display_name': 'Neuron', 'level': 2, 'score': 0.41447386}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.3384471}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.2486065}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.24284545}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.16820571}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13309833}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.101795554}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.084653705}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07520047}], 'mesh': [{'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072224', 'descriptor_name': 'Bcl-2-Like Protein 11', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002232', 'descriptor_name': 'Carbocyanines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002232', 'descriptor_name': 'Carbocyanines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071316', 'descriptor_name': 'Forkhead Box Protein O3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019394', 'descriptor_name': 'Ki-67 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019394', 'descriptor_name': 'Ki-67 Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mcn.2015.08.002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47891569', 'display_name': 'Molecular and Cellular Neuroscience', 'issn_l': '1044-7431', 'issn': ['1044-7431', '1095-9327'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26260111', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.82}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W1492401903', 'https://openalex.org/W1493876670', 'https://openalex.org/W1512339474', 'https://openalex.org/W1514939234', 'https://openalex.org/W1603686013', 'https://openalex.org/W1767023496', 'https://openalex.org/W1964451421', 'https://openalex.org/W196680064', 'https://openalex.org/W1969979382', 'https://openalex.org/W1974075485', 'https://openalex.org/W1974980101', 'https://openalex.org/W1977258127', 'https://openalex.org/W1980005230', 'https://openalex.org/W1981196417', 'https://openalex.org/W1986896225', 'https://openalex.org/W1987469323', 'https://openalex.org/W1991647627', 'https://openalex.org/W1992484817', 'https://openalex.org/W1996243898', 'https://openalex.org/W2001604240', 'https://openalex.org/W2006520473', 'https://openalex.org/W2006759122', 'https://openalex.org/W2009379812', 'https://openalex.org/W2017666196', 'https://openalex.org/W2022127378', 'https://openalex.org/W2024944389', 'https://openalex.org/W2025658684', 'https://openalex.org/W2026433865', 'https://openalex.org/W2034201098', 'https://openalex.org/W2034213169', 'https://openalex.org/W2035012085', 'https://openalex.org/W2038738480', 'https://openalex.org/W2048776263', 'https://openalex.org/W2051439699', 'https://openalex.org/W2052334874', 'https://openalex.org/W2052579653', 'https://openalex.org/W2052607700', 'https://openalex.org/W2055676865', 'https://openalex.org/W2059159698', 'https://openalex.org/W2062754118', 'https://openalex.org/W2065678329', 'https://openalex.org/W2071007484', 'https://openalex.org/W2073776090', 'https://openalex.org/W2075675471', 'https://openalex.org/W2076311537', 'https://openalex.org/W2085424855', 'https://openalex.org/W2092060809', 'https://openalex.org/W2096410114', 'https://openalex.org/W2096978860', 'https://openalex.org/W2104552307', 'https://openalex.org/W2106729121', 'https://openalex.org/W2109450020', 'https://openalex.org/W2112132009', 'https://openalex.org/W2115273281', 'https://openalex.org/W2122318491', 'https://openalex.org/W2133670735', 'https://openalex.org/W2134711807', 'https://openalex.org/W2137035181', 'https://openalex.org/W2140616438', 'https://openalex.org/W2141677575', 'https://openalex.org/W2146073155', 'https://openalex.org/W2154780300', 'https://openalex.org/W2157743819', 'https://openalex.org/W2162325038', 'https://openalex.org/W2171502370', 'https://openalex.org/W2171539213', 'https://openalex.org/W2414788290'], 'related_works': ['https://openalex.org/W4245280159', 'https://openalex.org/W3180989895', 'https://openalex.org/W2586972387', 'https://openalex.org/W2159916470', 'https://openalex.org/W2023960956', 'https://openalex.org/W2010958261', 'https://openalex.org/W1987342704', 'https://openalex.org/W1964746292', 'https://openalex.org/W1767023496', 'https://openalex.org/W1084638677'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1084638677', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-13T09:39:04.725224', 'created_date': '2016-06-24'}