Title: Chemokine Receptors in Cancer: Pathobiology and Potential Therapeutic Targets
Abstract: Many chemokine receptors have now been detected in a variety of malignancies. Considerable data now exist that two receptors, CXCR4 and CCR7, are widely expressed in epithelial cancers and contribute to the ability of some tumors to metastasize. Preclinical studies support a role for these receptors in mediating tumor cell migration, but other functions have also been identified including support of tumor cell proliferation in response to ligand stimulation. Less is known about the function of other chemokine receptors expressed in malignant cells, but it is likely that at least some of these also contribute to aggressive behavior. Although the specific role of each receptor is complex, it is becoming clear that these receptors may mediate metastasis to some, but not all, metastatic sites characteristic of each histologic type. Some of the site specificity is due to expression of the cognate ligand at the secondary site; however, other factors to be defined also contribute to chemokine receptor-determined metastatic patterns.
Publication Year: 2007
Publication Date: 2007-11-16
Language: en
Type: book-chapter
Indexed In: ['crossref']
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