Title: Interference at the Respiratory Burst Level Between the Signals Delivered in vitro in Human Peripheral Neutrophils via fMLP, Complement and Fc Receptors
Abstract: This chapter presents a study that seeks to establish the influence of the chemotactic signals on the phagocytosis-associated respiratory burst of polymorphonuclear granulocytes (PMNs). The functional interference of the signals simultaneously delivered in vitro by the chemotactic synthetic peptide fMet-Leu-Phe (fMLP) and zymosan particles not opsonized (Z), or opsonized with heat-inactivated normal serum (ZO), is investigated. The findings of the study suggest that neutrophils simultaneously challenged via fMLP receptors and CR3 develop only a weak respiratory burst, especially at high doses of N-formylated peptides, apparently a characteristic of the inflammatory site. The chemotactic peptide sustains the respiratory burst, primarily at its early phase, and the chemotactic factors exert a modulatory action on the microbicidal oxygen-dependent functions of PMNs. The respiratory burst elicited in the neutrophil subjected to low (chemotactic) concentration of fMLP is mainly represented by reactive oxygen species (ROS) elicited by phagocytosis-inducing stimuli, whereas inside the inflammatory site, a high (nonchemotactic) concentration sustains the oxidative response elicited by IgG opsonized particles.
Publication Year: 1997
Publication Date: 1997-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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