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Results for 'Youzhi Tong'
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Computerized Quantitation of Synergism and Antagonism of Taxol, Topotecan, and Cisplatin Against Human Teratocarcinoma Cell Growth: a Rational Approach to Clinical Protocol Design
Publication Year: 1994
DOI: https://doi.org/10.1093/jnci/86.20.1517
Abstract:
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Authors:
Ting‐Chao Chou
Robert J. Motzer
Yanli Tong
George J. Bosl
Abstract 614: Proxalutamide (GT0918), a potent androgen receptor pathway inhibitor
Publication Year: 2014
DOI: https://doi.org/10.1158/1538-7445.am2014-614
Abstract:
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Authors:
Youzhi Tong
Chunyun Chen
Juan Wu
Jiangtao Yang
Huihui Zhang
Xiaojun Wu
Yanmei Duan
Wei Gao
Weidong Qian
Xiaoxia Niu
Lili Mi
Chuangxing Guo
Abstract 1265: Discovery of GT19077, a c-Myc/Max protein-protein Interaction (PPI) small molecule inhibitor, and GT19506 a c-Myc PROTAC molecule, for targeting c-Myc-driven blood cancers and small cell lung cancers
Publication Year: 2021
DOI: https://doi.org/10.1158/1538-7445.am2021-1265
Abstract:
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Authors:
Liandong Ma
Youzhi Tong
Qianxiang Zhou
Zhao‐hui Yang
Honghau Yan
Ye Chen
XU Ruo
Jie Pan
Xiaoqi Gou
Weidong Qian
Jie Chen
Qi Sun
Luhua Lai
Abstract 5479: Discovery and evaluation of GT19630, a c-Myc/GSPT1 cereblon E3 ligase modulator (CELMoD), for targeting Myc-driven blood cancers and small cell lung cancers (SCLC)
Publication Year: 2022
DOI: https://doi.org/10.1158/1538-7445.am2022-5479
Abstract:
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Authors:
Liandong Ma
Youzhi Tong
Zhaohui Yang
Qianxiang Zhou
Hongha Yan
Xu Ru
Jie Chen
Jie Pan
Huiyuan Wang
Jiangwei Li
Dong Chen
Xiang Cai
Jie Qu
Yini Wang
Jun Qin
Yuki Nishida
Michael Andreeff
Qilnli Guo
Yuki Nishida
Michael Andreeff
Abstract 5274: Mechanisms of action (MOA) for proxalutamide, an androgen receptor (AR) antagonist, for the treatment of mild, moderate and severe COVID-19 patients
Publication Year: 2022
DOI: https://doi.org/10.1158/1538-7445.am2022-5274
Abstract:
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Authors:
Liandong Ma
Youzhi Tong
Qianxiang Zhou
Hongha Yan
Xiaodan Hou
Zhiha Ren
Jiangwei Li
Huiyuan Wang
Weidong Qian
Yu Zhang
Andy Goren
Arul M. Chinnaiyan
Abstract 2460: Discovery of potent androgen receptor antagonists for treating CRPC and AR+ breast cancer.
Publication Year: 2013
DOI: https://doi.org/10.1158/1538-7445.am2013-2460
Abstract:
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Authors:
Youzhi Tong
Chunyun Chen
Juan Wu
Huihui Zhang
Xiaojun Wu
Yanmei Duan
Wei Gao
Xiaoxia Niu
Linglan Ma
Chuangxing Guo
Abstract P2-17-05: Evaluation of safety, pharmacokinetics and pharmacodynamics of proxalutamide (GT0918), a potent androgen receptor (AR) blocker, in patients with metastatic breast cancer (mBC): Phase I dose escalation trial
Publication Year: 2020
DOI: https://doi.org/10.1158/1538-7445.sabcs19-p2-17-05
Abstract:
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Authors:
Huiping Li
Ran Ran
Guohong Song
Hanfang Jiang
Ru-Yan Zhang
Yaxin Liu
Luping Meng
Phoebe Zhang
Ke Chen
Qiaoxia Zhou
Karl Zhou
Youzhi Tong
Isolation and Characterization of Thymitaq (AG337) and 5-Fluoro-2-deoxyuridylate-resistant Mutants of Human Thymidylate Synthase from Ethyl Methanesulfonate-exposed Human Sarcoma HT1080 Cells
Publication Year: 1998
DOI: https://doi.org/10.1074/jbc.273.19.11611
Abstract:
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Authors:
Youzhi Tong
Xinyue Liu-Chen
Emine A. Ercikan-Abali
Gina Capiaux
Shi‐Cheng Zhao
Debabrata Banerjee
Joseph R. Bertino
Transmitting Chinese Medicine
Publication Year: 2013
DOI: https://doi.org/10.1163/15734218-12341319
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Abstract 711: Repurposing 2nd generation androgen receptor antagonist Proxalutamide to treat COVID-19
Publication Year: 2021
DOI: https://doi.org/10.1158/1538-7445.am2021-711
Abstract:
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Authors:
Liandong Ma
Youzhi Tong
Qiang Guo
Yifeng Zhou
Qianxiang Zhou
Honghua Yan
Abstract 6509: GT0486, a novel mTORC1/2 dual inhibitor, exhibits synergistic antitumor efficacy in combination with BTK inhibitors
Publication Year: 2024
DOI: https://doi.org/10.1158/1538-7445.am2024-6509
Abstract:
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Authors:
Xiaodan Hou
Honghua Yan
Xin Zhang
Weidong Qian
Dong Chen
Zhihua Ren
Youzhi Tong
Abstract 2735: High affinity and potent anti-tumor efficacy of Nivo813, an anti-PD-1/ALK-1 bispecific antibody, in pre-clinical studies for solid tumors
Publication Year: 2024
DOI: https://doi.org/10.1158/1538-7445.am2024-2735
Abstract:
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Authors:
Qingqing Zhou
Rong Tang
Lanfang Zhuang
Jianyu Huang
Qian Jiang
Zhihua Ren
Youzhi Tong
Abstract PS15-07: Proxalutamide plus Endocrine Therapies in Women with HR+/HER2-/AR+ Metastatic Breast Cancer: A Phase Ic Study
Publication Year: 2024
DOI: https://doi.org/10.1158/1538-7445.sabcs23-ps15-07
Abstract:
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Authors:
Huiping Li
Guohong Song
Hanfang Jiang
Xu Liang
Xiaojia Wang
Hua Yang
Lili Zhang
Youzhi Tong
Abstract 3297: Discovery and evaluation of GT19870, a GSPT1/Myc molecular glue drug (MGD) with oral bioavailability for targeting c-Myc and n-Myc-addictive blood cancer and solid tumors
Publication Year: 2024
DOI: https://doi.org/10.1158/1538-7445.am2024-3297
Abstract:
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Authors:
Liandong Ma
Youzhi Tong
Zhaohui Yang
Qiangxiang Zhou
Honghua Yan
Ru Xu
Dong Chen
Abstract 4978: Combination of a clinical stage-hedgehog inhibitor, GT1708, improves Venetoclax-induced apoptosis by down-regulating MCL-1 proteins in AML cells
Publication Year: 2023
DOI: https://doi.org/10.1158/1538-7445.am2023-4978
Abstract:
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Authors:
Liandong Ma
Qianxiang Zhou
Honghua Yan
Min Dong
Xiahe Han
Jiangwie Li
Jie Qu
Weidong Qian
Youzhi Tong
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