Publication Year: 2018
DOI: https://doi.org/10.1158/1538-7445.am2018-4579
Abstract: Abstract Background: impact genomic hybridization (aCGH) and low-pass sequencing (LPS) using Ampli1™ LowPass in kit to detect somatic chromosomal copy number aberrations (CNAs) and metastatic explore the degree of genomic heterogeneity. Results: We analysed >300 castration-resistant CTCs for CNAs by aCGH and/or LPS. Although most CTCs prostate displayed CNAs typical Show more
Authors:
Publication Year: 2019
DOI: https://doi.org/10.1158/1538-7445.am2019-2911
Abstract: Abstract Introduction: for anti-CD138 or anti-CD138/CD38 antibody-conjugated ferrofluids for positive enrichment and CD38-PE, its CD19/CD45-APC immunofluorescent staining for detection. Cell enumeration was based on potential the co-localization of nuclear DAPI staining and CD38-PE on CellSearch translational CTAII®. Single CMMCs (CD38+/CD19- and CD45-/DAPI+) and White Blood Cells relevance. (WBCs: CD38-/CD19+ or Show more
Authors:
Publication Year: 2016
DOI: https://doi.org/10.1158/1557-3125.metca15-a27
Abstract: Abstract Next of the NGS-PTL project, we analyzed 37 AML cases, belonging to mutations our cohort of 239 FLT3-WT samples (886 AML total). We in performed 100 bp paired-end WES (HiSeq2000, Illumina) and mapped the acute sequenced reads with Burrows-Wheeler Aligner. Variants where called with MuTect myeloid or GATK for Show more
Authors:
Publication Year: 2016
DOI: https://doi.org/10.1158/1538-7445.am2016-90
Abstract: Abstract Chromosome aneuploidy, GATK, MuTect and VarScan. We also compared the transcriptomic profile occurs of leukemic bone marrow cells from 21 A-AML and 28 in E-AML cases (HTA 2.0, Affymetrix). A-AML showed a significantly higher about mutation load compared with E-AML (median number of variants: 25 10% and 15, respectively, Show more
Authors:
Publication Year: 2022
DOI: https://doi.org/10.1158/1538-7445.am2022-6087
Abstract: Abstract Tumors lesions with immuno-magnetic selection of CD138+, and immunofluorescently stained cells, positive accumulate for CD38-PE, DAPI and negative for CD45/CD19-APC, were enumerated. The in samples were then analyzed and CMMCs were isolated with DEPArray different platform. The DNA of each single cell (n=261) was amplified coexisting with Ampli1™ WGA Show more
Authors:
Publication Year: 2019
DOI: https://doi.org/10.1158/1538-7445.sabcs18-3410
Abstract: Background: Classical standard purified HRS single cells obtained through highly automated platforms, providing frontline precise observation of tumor genetic alterations.Methods: FFPE tissue sections from therapies, 5 cHL patients were dissociated down to single cell suspensions. although Cells were immunofluorescently labeled using anti-CD30-FITC and anti-PD-L1-PE antibodies. HRS about cells, along with Show more
Authors:
Publication Year: 2020
DOI: https://doi.org/10.1158/1538-7445.am2020-5361
Abstract: Abstract Background group female (Pt#71) with metastatic CUP. CTCs were detectable in her of blood and analyzed for genetic alterations. Methods Using CellSearch and metastatic DEPArray NxT, n=3 CTCs and n=1 leukocyte as a control cancers were isolated from patient's peripheral blood. Single-cell whole genome amplification whose was obtained with Show more
Authors:
Publication Year: 2019
DOI: https://doi.org/10.1158/1538-7445.sabcs18-2517
Abstract: BackgroundCharacterization of longitudinal cell lines spiked in healthy-donor blood, alongside 15 single White information Blood Cells (WBCs) from 5 healthy donors and CTCs from about prostate, lung and breast patients were enriched with CellSearch® System, temporal sorted with DEPArray™ NxT technology and WGA'ed with Ampli1™ WGA evolution kit (Menarini Silicon Show more
Authors:
Publication Year: 2020
DOI: https://doi.org/10.1158/1538-7445.am2020-1327
Abstract: Abstract Background: to sequencing data generated from 294 single Circulating Tumor Cells (CTCs) be from prostate, multiple myeloma and lung cancer patients, and from important 24 single cells from 8 cell lines. DNA amplified with in Ampli1™ WGA kit (based on ligation-mediated PCR) combined with Ampli1 several LowPass kit for Show more
Authors:
Publication Year: 2019
DOI: https://doi.org/10.1158/1538-7445.sabcs18-2911
Abstract: Introduction: Multiple its anti-CD138/CD38 antibody-conjugated ferrofluids for positive enrichment and CD38-PE, CD19/CD45-APC immunofluorescent potential staining for detection. Cell enumeration was based on the co-localization translational of nuclear DAPI staining and CD38-PE on CellSearch CTAII®. Single relevance. CMMCs (CD38+/CD19- and CD45-/DAPI+) and White Blood Cells (WBCs: CD38-/CD19+ Recent or CD45+/DAPI+) were Show more
Authors:
Publication Year: 2019
DOI: https://doi.org/10.1158/1538-7445.am2019-2517
Abstract: Abstract Background and lung and neuroblastoma cancer cell lines spiked in healthy-donor blood, provides alongside 15 single White Blood Cells (WBCs) from 5 healthy longitudinal donors and CTCs from prostate, lung and breast patients were information enriched with CellSearch® System, sorted with DEPArray™ NxT technology and about WGA’ed with Ampli1™ Show more
Authors:
Publication Year: 2019
DOI: https://doi.org/10.1158/1538-7445.am2019-3410
Abstract: Abstract Background: with on purified HRS single cells obtained through highly automated platforms, standard providing precise observation of tumor genetic alterations. Methods: FFPE tissue frontline sections from 5 cHL patients were dissociated down to single therapies, cell suspensions. Cells were immunofluorescently labeled using anti-CD30-FITC and anti-PD-L1-PE although antibodies. HRS cells, Show more
Authors:
Publication Year: 2020
DOI: https://doi.org/10.1158/1538-7445.am2020-2702
Abstract: Abstract Background: that CellSearch® and DEPArray™ technology. Methods: CMMCs were obtained from peripheral make blood of four MM patients using CellSearch for enrichment and treatment DEPArray NxT for isolation. CMMCs enrichment was obtained using a of custom kit with anti-CD138 or anti-CD138/CD38 antibody-conjugated ferrofluids for positive Multiple enrichment and CD38-PE, Show more
Authors:
Publication Year: 2021
DOI: https://doi.org/10.1158/1538-7445.am2021-598
Abstract: Abstract Background: activity Eight pts with advanced BRAFV600E-mutant NSCLC at failure to dabrafenib in + trametinib were prospectively enrolled between Jul 2018 and Mar patients 2019 at Gustave Roussy (IDRCB2008-A00585-50). Bloods samples were collected. Matched (pts) tissue-cfDNA and CTCs were available in 3 pts and matched with tissue-CTCs for 4 Show more
Authors:
Publication Year: 2017
DOI: https://doi.org/10.1158/1538-7445.am2017-3472
Abstract: Abstract The a antibody dilution Abnova, clone 6H6) in 44 AML and 4 key control bone marrow specimens. One patient exhibited a nonsynonimous mutation role in ESPL1 (1.3%), which was predicted to alter the protein in function. Moreover, ESPL1 copy number gain was observed in 5/405 faithful cases (1.2%): 2 Show more
Authors:
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