Publication Year: 1964
DOI: https://doi.org/10.1073/pnas.51.3.414
Abstract: Not available
Authors:
Publication Year: 2003
DOI: https://doi.org/10.1128/aac.47.11.3407-3414.2003
Abstract: ABSTRACT Staphylococci in of the strains are inhibited [MIC 90 ], 0.001 to an 0.064 μg/ml) and is also effective against Staphylococcus epidermidis at extracellular higher concentrations (MIC 90 , 12.5 to 64 μg/ml). The matrix activity of lysostaphin against staphylococci present in biofilms compared to that those of other Show more
Authors:
Publication Year: 1972
DOI: https://doi.org/10.1111/j.1432-1033.1972.tb02023.x
Abstract: Previous methods protein ± 6. Less than 0.2% hexosamines was present. The ultraviolet A, spectrum and the absorption coefficient, A 1% 275nm = 1.65 such of protein A is given. Less than 0.1 mol amino as terminal amino acid per mol protein was detected which indicates thermal that the protein Show more
Authors:
Publication Year: 2010
DOI: https://doi.org/10.3390/ph3041139
Abstract: Lysostaphin is of by staphylococci continue to be a problem worldwide not only antimicrobial in healthcare environments but also in the community, requiring effective peptides measures for controlling their spread. Since lysostaphin kills human and and animal staphylococcal pathogens, it has potential biotechnological applications in the proteins treatment of staphylococcal Show more
Authors:
Publication Year: 1965
DOI: https://doi.org/10.1016/0006-291x(65)90473-0
Abstract: Not available
Authors:
Publication Year: 2008
DOI: https://doi.org/10.1007/s00253-008-1579-y
Abstract: Not available
Authors:
Publication Year: 2008
DOI: https://doi.org/10.1128/jb.01116-08
Abstract: The advent virtually swelling, splitting of the septum, and creation of nanoscale perforations. all Notably, treatment of the cells with lysostaphin was also found antibiotics to decrease the bacterial spring constant and the cell wall has stiffness, demonstrating that structural changes were correlated with major differences increased in cell wall Show more
Authors:
Publication Year: 2008
DOI: https://doi.org/10.1111/j.1574-6968.2008.01308.x
Abstract: LysK is can digest the cell wall of many staphylococci. Lysostaphin is the a bacteriocin secreted by Staphylococcus simulans to kill Staphylococcus aureus. endolysin Both LysK and lysostaphin have been shown to lyse methicillin-resistant from S. aureus (MRSA). This study describes optimal reaction conditions for the the recombinant His-tagged LysK Show more
Authors:
Publication Year: 2018
DOI: https://doi.org/10.1073/pnas.1801013115
Abstract: Significance Orthopedic debridement hydrogels are effective against antibiotic-resistant infections. This lysostaphin delivery platform to could be highly effective at treating and preventing implant infections. successfully retain the implant; however, therapeutic failure can implant lead to implant removal. Here an injectable PEG-based hydrogel that infections adheres to exposed tissue and fracture Show more
Authors:
Publication Year: 1987
DOI: https://doi.org/10.1073/pnas.84.5.1127
Abstract: A 1.5-kilobase-pair from sequence of DNA. In S. simulans, the lysostaphin gene is Staphylococcus present on a large beta-lactamase plasmid. simulans and its flanking sequences has been cloned fragment and completely sequenced. The gene encodes a preproenzyme of Mr of 42,000. The NH2-terminal sequence of the preproenzyme is composed of Show more
Authors:
Publication Year: 2003
DOI: https://doi.org/10.1128/aac.47.5.1589-1597.2003
Abstract: ABSTRACT The Staphylococcus growing and quiescent S. aureus . This study demonstrates that aureus a single application of 0.5% lysostaphin (actual dose, ∼150 μg , of lysostaphin), formulated in a petrolatum-based cream, dramatically reduces S. and aureus nasal colonization in 100% of animals tested and eradicates nasal S. aureus nasal Show more
Authors:
Publication Year: 1973
DOI: https://doi.org/10.1111/j.1432-1033.1973.tb03061.x
Abstract: The bacteriolytic supernatant of Staphylococcus epidermidis , NRRL B‐2628 (K‐6‐W1) on the agent ion‐exchange resin Amberlite IRC‐50. A salt gradient released three enzyme lysostaphin specificities which were further purified to apparent homogeneity. These enzymes, has belonging to three different classes, were endo‐β‐ N ‐ acetylglucosaminidase, been endopeptidase (glycinase) and N Show more
Authors:
Publication Year: 1998
DOI: https://doi.org/10.1128/aac.42.6.1355
Abstract: ABSTRACT The with lysostaphin given three times daily, produced sterile vegetations in 10 reduced of 11 treated rabbits, with a mean reduction in vegetation susceptibility bacterial counts of 8.5 log 10 CFU/g compared to the to counts in the untreated controls. In contrast, vancomycin given twice vancomycin daily sterilized no Show more
Authors:
Publication Year: 2012
DOI: https://doi.org/10.1128/aem.07050-11
Abstract: Staphylococci cause the 100 μg/ml in processed cow milk, λSA2-E-Lyso-SH3b and λSA2-E-LysK-SH3b reduced majority the S. aureus bacterial load by 3 and 1 log of units within 3 h, respectively, compared to a buffer control. the In contrast to λSA2-E-Lyso-SH3b, however, λSA2-E-LysK-SH3b permitted regrowth of the mastitis-based pathogen after 1 Show more
Authors:
Publication Year: 2003
DOI: https://doi.org/10.1128/aac.47.2.554-558.2003
Abstract: ABSTRACT Lysostaphin cell which could potentially reduce enzymatic function. Enzymatic activity for most wall PEGylated lysostaphins was reduced, but these compounds were still considerably of active compared to unconjugated lysostaphin, with conjugates that had lower Staphylococcus degrees of PEG modification having greater activity than those with aureus higher degrees. PEGylated Show more
Authors:
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