Publication Year: 2022
DOI: https://doi.org/10.1158/1538-7445.am2022-3929
Abstract: Abstract Myc However, degron allowing for the recruitment of the E3 ligase cereblon despite (CRBN) and subsequent proteasomal degradation in the presence of molecular being glue degraders. Herein we describe a novel orally bioavailable GSPT1-directed amongst small molecule degrader MRT-2359, which has been rationally designed and the optimized to selectively Show more
Authors:
Publication Year: 2023
DOI: https://doi.org/10.1158/1538-7445.am2023-3449
Abstract: Abstract MYC but designed using our QuEENTM discovery engine and optimized to achieve despite a profound and preferential antiproliferative activity in MYC-driven cell lines, being such as high N- and L-MYC mRNA expressing non-small cell amongst lung cancer (NSCLC) and small cell lung cancer (SCLC) lines. the In line with Show more
Authors:
Publication Year: 2021
DOI: https://doi.org/10.1158/1535-7163.targ-21-lba004
Abstract: Abstract The driver may constitute a vulnerability for Myc-driven tumors. Using our proprietary of Quantitative and Engineered Elimination of Neosubstrates (QuEENTM) platform we characterized human and explored the known G-loop degron in GSPT1 that renders cancers. it amenable to cereblon-induced degradation by molecular glue degraders (MGDs). However, We rationally designed Show more
Authors:
Publication Year: 2010
DOI: https://doi.org/10.1101/gad.1940710
Abstract: The p53 stress on their own induce T-cell malignancies with long latency. This through synergy is based on a pivotal role of p53 in several limiting aberrant self-renewal of myeloid progenitor cells, such that loss mechanisms. of p53 counters the deleterious effects of oncogenic Kras on Here, these cells and Show more
Authors:
Publication Year: 2005
DOI: https://doi.org/10.1111/j.1365-2958.2005.04545.x
Abstract: Summary The of protein level or a strong reduction respectively. Moreover, these changes light in PKC activity result in an altered light response. As responsive WC‐1 is a key component of Neurospora circadian clock and genes. regulates the clock oscillator component FRQ we investigated the effect We of NPKC‐mutated forms Show more
Authors:
Publication Year: 2011
DOI: https://doi.org/10.1186/bcr2804
Abstract: Abstract Introduction levels on the estrogen-mediated proliferation signals we generated MCF-7 cell lines of with inducible shRNA for mdm2 or p53 and monitored their Mdm2. influence on estrogen-mediated outcomes. To further address the p53-independent effect We of Mdm2 in ERα positive breast cancer we generated cell investigated lines with inducible Show more
Authors:
Publication Year: 2011
DOI: https://doi.org/10.1111/j.1474-9726.2011.00719.x
Abstract: The expression and the oncoprotein Mdm2. The expression of E2F target genes, normally lamin required for cell cycle progression, was downregulated after lamin A/C defects depletion but restored after the inactivation of p53. A similar are senescence response was observed in myoblasts from a patient with the a lamin A Show more
Authors:
Publication Year: 2007
DOI: https://doi.org/10.1130/g23549a.1
Abstract: Research Article| ion Australia Search for other works by this author on: GSW microprobe Google Scholar Author and Article Information Mónica P. Escayola 1Consejo U-Pb Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de and Salta, Buenos Aires 177, 4400 Salta, Argentina Márcio M. Pimentel Sm-Nd 2Instituto de Geociências, Show more
Authors:
Publication Year: 1998
DOI: https://doi.org/10.1038/sj.onc.1201631
Abstract: Not available
Authors:
Publication Year: 1991
DOI: https://doi.org/10.2307/3338671
Abstract: Between 1855 to become economic stagnation and relatively limited social change. Mexico's liberal consensus was achieved the before the emergence of a substantial, economically influential middle class. national political consensus.1 This apparent monopoly of ideological discourse and enjoyed by Liberalism was, of course, helped by the disappearance of 1867, 'Conservatism' from the political vocabulary, disgraced by Show more
Authors:
Publication Year: 2019
DOI: https://doi.org/10.15381/is.v22i40.15899
Abstract: El presente a mujeres travestis a partir de su cotidianeidad y con referencia la a determinadas condiciones socioeconómicas, así como profundizar un poco en Erasmus los motivos —personales y sociales— subyacentes a esos significados. University Rotterdam para optar el título de trabajo magíster en Development Studies. El concepto de trabajo Show more
Authors:
Publication Year: 1999
DOI: https://doi.org/10.1016/s0024-4937(98)00074-7
Abstract: Not available
Authors:
Publication Year: 2023
DOI: https://doi.org/10.1158/1538-7445.am2023-nd10
Abstract: Abstract MYC of lines, kinetics and depth of degradation, oral bioavailability, and in many vivo efficacy. The anti-tumor activity of MRT-2359 was assessed in cancers, more than 80 lung patient-derived xenografts (PDXs) that confirmed the yet preferential anti-tumor activity in N- and L-MYC high NSCLC and have SCLC PDXs when Show more
Authors:
Publication Year: 1999
DOI: https://doi.org/10.1016/s0736-5748(99)00004-0
Abstract: Abstract Differentiation part (first synaptic) layer. By the time of eye opening (about of 34 days) the basic histological organization of the mature retina nervous was established. In the mature retina and during development, horizontal system cell neurites in the outer plexiform layer, as well as development. ganglion cell axons, Show more
Authors:
Publication Year: 1995
DOI: https://doi.org/10.1017/s0956536100002066
Abstract: Abstract This Guerrero's Costa Chica and on itinerant salt trading conducted by paper highland Nahuatl villagers. The findings are compared with studies of provides salt production elsewhere in Mesoamerica, and the nature and quality data of oral-historical sources are evaluated. Based primarily on extensive ethnographic on fieldwork, the paper explores Show more
Authors:
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