Title: Comparison of three sample types for performing LDBio Aspergillus immunochromatographic technology lateral flow assay for IgG/IgM antibody detection in chronic aspergillosis
Abstract: The detection of IgG against Aspergillus fumigatus is the most crucial investigation in diagnosing chronic pulmonary aspergillosis (CPA) and is also an essential investigation for allergic bronchopulmonary aspergillosis (ABPA) [1,2]. Several commercially available methods for detecting A.fumigatus-specific IgG exist. However, most commercial platforms require expensive equipment and are not routinely available in field settings, especially in resource-constrained countries. Recently, a point-of-care lateral flow assay (LFA) for detecting A.fumigatus-IgG/IgM was shown to have sensitivity and specificity of 89% and 96%, respectively, in chronic aspergillosis (CPA and ABPA) [3,4].