A novel leishmanial copper P-type ATPase plays a vital role in parasite infection and intracellular survival

Name: Work Video:
Duration: 3 min 30 s
Rupam Paul; Sourav Banerjee; Samarpita Sen; Pratiksha Dubey; Saptarshi Maji; Anand Bachhawat; Rupak Datta; Arnab Gupta
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'https://openalex.org/W3092180926', 'https://openalex.org/W3093921521', 'https://openalex.org/W3103730625', 'https://openalex.org/W3110418371', 'https://openalex.org/W3112209297', 'https://openalex.org/W3190923317', 'https://openalex.org/W4211073781', 'https://openalex.org/W434170'], 'related_works': ['https://openalex.org/W4394683171', 'https://openalex.org/W4307269441', 'https://openalex.org/W4249388868', 'https://openalex.org/W4211086931', 'https://openalex.org/W3135513598', 'https://openalex.org/W3004741199', 'https://openalex.org/W2475319473', 'https://openalex.org/W2090618803', 'https://openalex.org/W2001843323', 'https://openalex.org/W1177314572'], 'abstract_inverted_index': {'Copper': [0, 252, 1026, 1110, 1344, 1572, 2260, 2933], '(Cu)': [1, 253, 1027], 'is': [2, 254, 505, 550, 1028, 1073, 1132, 1334, 1610, 2187, 2230, 2416, 2461, 2476, 2508, 2668, 3242, 3285, 3355, 3578, 3602, 3680, 3735, 4030], 'essential': [3, 255, 713, 1030, 1081, 3449, 3472, 3731], 'for': [4, 256, 715, 1032, 1470, 1515, 1846, 2093, 2315, 2323, 2556, 2665, 2686, 2738, 2793, 2846, 2854, 2865, 2871, 2878, 3306, 3592, 3765, 3823, 4066], 'all': [5, 257, 4078], 'life': [6, 258], 'forms;': [7, 259], 'however,': [8, 260], 'in': [9, 31, 61, 68, 71, 110, 159, 171, 176, 183, 191, 202, 218, 246, 261, 283, 313, 320, 323, 362, 411, 423, 428, 435, 443, 454, 470, 498, 717, 754, 785, 913, 942, 999, 1038, 1083, 1099, 1154, 1171, 1193, 1235, 1288, 1353, 1378, 1475, 1520, 1535, 1547, 1573, 1614, 1622, 1628, 1643, 1662, 1709, 1712, 1740, 1743, 1756, 1765, 1770, 1851, 1870, 1885, 1894, 1900, 1930, 1962, 2101, 2117, 2164, 2184, 2198, 2296, 2303, 2326, 2336, 2342, 2348, 2368, 2412, 2425, 2443, 2451, 2470, 2489, 2503, 2516, 2607, 2618, 2656, 2670, 2963, 2978, 3005, 3093, 3104, 3172, 3300, 3359, 3432, 3445, 3500, 3514, 3531, 3536, 3567, 3627, 3689, 3718, 3738, 3755, 3791, 3825, 3843, 3854, 3886, 3892, 3897, 3915, 3934, 3943, 3947, 3990, 4002, 4012, 4048, 4051, 4077, 4084, 4101, 4134, 4180, 4278, 4311, 4357, 4372], 'excess,': [10, 262], 'it': [11, 211, 263, 463, 971, 3110, 3241, 3245, 4261], 'becomes': [12, 189, 264, 441, 3730], 'toxic.': [13, 265], 'Toxic': [14, 266], 'properties': [15, 267, 2388], 'of': [16, 47, 153, 163, 244, 268, 299, 405, 415, 496, 531, 541, 555, 566, 624, 661, 673, 741, 773, 793, 810, 888, 891, 959, 966, 1045, 1065, 1104, 1157, 1169, 1229, 1238, 1257, 1263, 1282, 1307, 1312, 1330, 1348, 1373, 1393, 1435, 1639, 1660, 1676, 1702, 1721, 1738, 1776, 1811, 1867, 1891, 1920, 1955, 1980, 2000, 2014, 2031, 2062, 2090, 2119, 2135, 2167, 2227, 2263, 2371, 2389, 2394, 2398, 2459, 2467, 2479, 2493, 2527, 2552, 2582, 2624, 2632, 2660, 2680, 2689, 2716, 2729, 2745, 2750, 2771, 2784, 2800, 2805, 2826, 2842, 2882, 2894, 2939, 2954, 2959, 3032, 3061, 3080, 3097, 3124, 3134, 3137, 3161, 3212, 3287, 3296, 3319, 3330, 3338, 3413, 3429, 3438, 3442, 3451, 3483, 3496, 3562, 3565, 3571, 3607, 3613, 3624, 3647, 3706, 3783, 3839, 3888, 3928, 3987, 4027, 4099, 4137, 4142, 4191, 4200, 4248, 4314, 4323, 4360, 4365], 'Cu': [17, 41, 108, 122, 126, 144, 156, 269, 293, 360, 374, 378, 396, 408, 1046, 1072, 1105, 1122, 1136, 1148, 1188, 1338, 1387, 1408, 1491, 1538, 1549, 1744, 1754, 1778, 1899, 1922, 1956, 1982, 2001, 2010, 2033, 2067, 2092, 2124, 2150, 2174, 2183, 2216, 2225, 2244, 2290, 2317, 2327, 2918, 3012, 3311, 3322, 3346, 3363, 3373, 3385, 3460, 3467, 3481, 3525, 3553, 3569, 3651, 3679, 3988, 4000, 4004, 4044, 4065, 4104, 4144, 4179, 4236, 4250, 4259, 4275, 4291, 4324, 4333, 4366], 'are': [18, 270, 524, 598, 683, 859, 1097, 1198, 1350, 1376, 1533, 1543, 1556, 1657, 2634, 2886, 3560], 'known': [19, 271, 525, 536], 'to': [20, 143, 169, 195, 272, 395, 421, 447, 510, 526, 563, 590, 610, 763, 770, 806, 830, 863, 876, 975, 986, 1047, 1062, 1175, 1201, 1240, 1265, 1317, 1389, 1406, 1409, 1498, 1619, 1726, 1967, 2059, 2087, 2095, 2220, 2246, 2309, 2418, 2513, 2542, 2586, 2636, 2926, 3007, 3073, 3204, 3313, 3344, 3424, 3469, 3477, 3512, 3652, 3667, 3686, 3703, 3711, 3714, 3725, 3744, 3753, 3847, 3867, 3911, 4009, 4139, 4154, 4301, 4362, 4381, 4387], 'be': [21, 273, 1138, 1883, 2294, 2321, 3454, 3922], 'utilized': [22, 274], 'by': [23, 51, 275, 303, 552, 686, 720, 739, 747, 2572, 2713, 2768, 2823, 2890, 3153, 3831], 'host': [24, 72, 276, 324, 677, 873, 990, 1449, 1713, 1825], 'species': [25, 277, 548], 'against': [26, 278, 865, 1787], 'various': [27, 279], 'pathogenic': [28, 280, 2237], 'invasions.': [29, 281], 'Leishmania,': [30, 52, 177, 282, 304, 429, 3098, 4052], 'both': [32, 284, 2557, 2600, 3264, 4164], 'free-living': [33, 285, 1741, 2110], 'and': [34, 55, 64, 106, 131, 161, 193, 229, 237, 249, 286, 307, 316, 358, 383, 413, 445, 481, 489, 501, 520, 549, 588, 621, 658, 791, 819, 948, 979, 1014, 1017, 1051, 1057, 1129, 1143, 1210, 1213, 1218, 1231, 1290, 1309, 1332, 1346, 1355, 1370, 1398, 1440, 1542, 1554, 1655, 1674, 1691, 1705, 1773, 1816, 1905, 1911, 1917, 1952, 2021, 2051, 2272, 2385, 2448, 2465, 2485, 2497, 2525, 2532, 2560, 2629, 2642, 2709, 2764, 2819, 2849, 2856, 2863, 2869, 2873, 2876, 2919, 2995, 3003, 3101, 3108, 3149, 3157, 3175, 3217, 3223, 3238, 3261, 3340, 3351, 3391, 3408, 3419, 3471, 3486, 3597, 3779, 3827, 3841, 3879, 3881, 3980, 4057, 4071, 4108, 4145, 4166, 4204, 4293, 4350, 4368, 4383], 'intracellular': [35, 287, 789, 847, 1130, 1146, 1412, 1750, 2120, 3135, 3248, 3302, 3480], 'forms,': [36, 288], 'exhibits': [37, 80, 102, 289, 332, 354, 2215], 'appreciable': [38, 290, 2222, 3357], 'tolerance': [39, 291, 2219], 'toward': [40, 292, 4118], 'stress.': [42, 145, 294, 397, 1745, 4251], 'While': [43, 295], 'determining': [44, 296, 1766], 'the': [45, 94, 166, 187, 196, 242, 297, 346, 418, 439, 448, 494, 511, 542, 546, 567, 611, 669, 742, 755, 758, 766, 771, 774, 844, 889, 910, 914, 967, 980, 989, 1043, 1102, 1113, 1155, 1167, 1232, 1236, 1261, 1390, 1448, 1471, 1516, 1540, 1544, 1557, 1578, 1597, 1686, 1698, 1718, 1727, 1735, 1771, 1824, 1847, 1892, 1924, 1938, 1973, 1984, 1997, 2003, 2012, 2029, 2054, 2137, 2165, 2181, 2185, 2208, 2264, 2273, 2297, 2330, 2343, 2354, 2369, 2390, 2431, 2438, 2444, 2452, 2471, 2490, 2494, 2498, 2509, 2517, 2544, 2587, 2622, 2637, 2652, 2661, 2671, 2677, 2683, 2702, 2707, 2710, 2714, 2717, 2725, 2732, 2742, 2746, 2757, 2762, 2765, 2769, 2772, 2780, 2787, 2797, 2801, 2812, 2817, 2820, 2824, 2827, 2835, 2883, 2891, 2901, 2912, 2924, 2927, 2937, 2955, 2964, 2971, 2999, 3008, 3038, 3062, 3070, 3074, 3094, 3125, 3144, 3162, 3184, 3213, 3228, 3247, 3259, 3297, 3301, 3325, 3378, 3389, 3395, 3426, 3439, 3479, 3508, 3521, 3532, 3537, 3543, 3546, 3556, 3563, 3572, 3608, 3614, 3643, 3653, 3671, 3674, 3697, 3704, 3715, 3746, 3750, 3784, 3800, 3805, 3849, 3855, 3860, 3863, 3889, 3926, 3929, 3953, 3966, 3996, 4073, 4085, 4089, 4096, 4122, 4135, 4148, 4181, 4212, 4231, 4239, 4269, 4312, 4326, 4344, 4358, 4376], 'mechanism': [46, 298, 3079, 3387], 'Cu-stress': [48, 300], 'evasion': [49, 301], 'employed': [50, 302], 'we': [53, 178, 305, 430, 1694, 1888, 2042, 2112, 2359, 2968, 3099, 3333, 3583, 3950, 3976, 3992, 4053, 4080, 4124], 'identified': [54, 306], 'characterized': [56, 308, 1697, 2889], 'a': [57, 111, 180, 309, 363, 432, 506, 528, 553, 584, 607, 808, 828, 851, 960, 1150, 1190, 1489, 1611, 1722, 1762, 1784, 1901, 1927, 2114, 2161, 2362, 2480, 2550, 2579, 3033, 3112, 3131, 3177, 3335, 3372, 3382, 3402, 3409, 3466, 3579, 3585, 3662, 3687, 3761, 3792, 3813, 3984, 4046, 4264, 4287, 4304], 'hitherto': [58, 310], 'unknown': [59, 311], 'Cu-ATPase': [60, 312, 1613, 1633, 1724, 3645, 3985], 'Leishmania': [62, 149, 314, 401, 504, 547, 674, 780, 804, 892, 895, 935, 977, 1703, 1886, 2035, 2312, 4103], 'major': [63, 77, 154, 315, 329, 406, 893, 1704, 2049, 2214, 2229, 2529, 2594, 2614, 3434, 3492, 4060, 4172], 'established': [65, 190, 317, 442, 3981], 'its': [66, 83, 318, 335, 662, 1127, 1707, 1767, 1931, 2301, 2324, 2426, 2563, 2921, 2979, 3307, 3598, 3972, 4253], 'role': [67, 243, 319, 495, 714, 1192, 1228, 1469, 1514, 1708, 1737, 1764, 1845, 3441, 3564, 4047, 4098], 'parasite': [69, 247, 321, 499, 1893, 1925, 1963, 1985, 2138, 2186, 2298, 3188, 3446, 3539, 4149, 4345], 'survival': [70, 120, 322, 372, 2325], 'macrophages.': [73, 325], 'This': [74, 326, 2915, 3284, 3600, 4271], 'novel': [75, 327, 3078], 'L.': [76, 328, 922, 2048, 2213, 2228, 2372, 2528, 2613, 3433, 3491, 3935, 4059, 4171], 'Cu-ATPase,': [78, 330, 3582], 'LmATP7,': [79, 331], 'homology': [81, 333, 2666, 2687, 2739, 2794, 2949, 2985], 'with': [82, 129, 141, 221, 235, 334, 381, 393, 473, 487, 827, 843, 850, 963, 1267, 1488, 1577, 1898, 1972, 1989, 2047, 2057, 2085, 2103, 2122, 2142, 2152, 2235, 2651, 2701, 2756, 2811, 2834, 2986, 3111, 3130, 3143, 3239, 3267, 3520, 3555, 3661, 3776, 3877, 3965, 4032, 4062, 4093, 4177, 4257, 4307, 4331, 4338], 'orthologs': [84, 336, 2993], 'at': [85, 93, 337, 345, 1112, 1149, 1908, 1943, 1950, 1965, 1977, 2007, 2019, 2146, 2170, 2189, 2900, 2998, 3208, 3231, 3263, 3324, 4152, 4196, 4216, 4233, 4303, 4353], 'multiple': [86, 338], 'motifs.': [87, 339], 'In': [88, 340, 708, 1551, 1685, 1730, 3673, 3693, 3858, 4194], 'promastigotes,': [89, 341, 2111], 'LmATP7': [90, 101, 117, 133, 184, 201, 245, 342, 353, 369, 385, 436, 453, 497, 1739, 1759, 2475, 2609, 2633, 3091, 3299, 3339, 3360, 3369, 3404, 3414, 3452, 3487, 3497, 3566, 3577, 3778, 3840, 3878, 3901, 3920, 3939, 3968, 3982, 4049, 4100], 'primarily': [91, 343], 'localized': [92, 344], 'plasma': [95, 347, 2203, 3009, 3075, 3095, 3116, 3229, 3288, 3654], 'membrane.': [96, 348], 'We': [97, 136, 146, 349, 388, 398, 1746, 2027, 2064, 2285, 2307, 2645, 3365, 3399, 3835, 4340], 'also': [98, 350, 870, 1335, 1747, 2477, 3463, 4342, 4379], 'show': [99, 351, 3191], 'that': [100, 148, 352, 400, 514, 557, 983, 1187, 1559, 1749, 1760, 2180, 2212, 2287, 2299, 2319, 2734, 2789, 2970, 2982, 3139, 3160, 3165, 3180, 3367, 3503, 3588, 3808, 3819, 3837, 3905, 3952, 3960], 'Cu-dependent': [103, 355], 'expression': [104, 356, 875, 2565, 3495, 3838, 3887], 'patterns': [105, 357], 'complements': [107, 359], 'transport': [109, 361, 1128, 1594, 2922, 3060], 'Cu-ATPase-deficient': [112, 364], 'yeast': [113, 365, 1174, 1623, 3615, 3675, 3893], 'strain.': [114, 366, 2626], 'Promastigotes': [115, 367], 'overexpressing': [116, 200, 368, 452, 3377, 3405], 'exhibited': [118, 370, 2462], 'higher': [119, 230, 371, 482, 1663, 4229, 4265], 'upon': [121, 373, 1337, 3011, 3362], 'stress,': [123, 375], 'indicating': [124, 376, 1996, 2562, 3353, 3904, 3959, 4095, 4188, 4220], 'efficacious': [125, 377], 'export': [127, 379, 3386, 4276], 'compared': [128, 234, 380, 486, 1971, 2151, 2234, 3519, 3554, 3876], 'Wt': [130, 382, 3187, 3390, 3522, 3538, 4165, 4203, 4308], 'heterozygous': [132, 384, 3396, 3410, 3488, 3515], 'knockout': [134, 386, 3428], 'parasites.': [135, 387], 'further': [137, 389], 'explored': [138, 390], 'macrophage–Leishmania': [139, 391], 'interactions': [140, 392, 784], 'respect': [142, 394], 'found': [147, 399, 2113, 2736, 2791], 'infection': [150, 402, 565, 775, 897, 1266, 1401, 2334], 'triggers': [151, 403], 'upregulation': [152, 404], 'mammalian': [155, 407, 521, 676, 2987, 4013], 'exporter,': [157, 409], 'ATP7A,': [158, 410], 'macrophages,': [160, 208, 412, 460], 'trafficking': [162, 414], 'ATP7A': [164, 416, 1472, 1517, 1654, 1848, 2807, 2994, 4011, 4028], 'from': [165, 417, 559, 601, 749, 946, 1173, 1539, 1596, 1934, 1992, 2128, 2132, 2537, 2611, 2621, 3037, 3069, 3159, 3670, 4160, 4184, 4283, 4320], 'trans-Golgi': [167, 419, 3000, 3039], 'network': [168, 420, 3001], 'endolysosomes': [170, 422], 'macrophages': [172, 192, 424, 444, 687, 945, 1331, 1375, 2046, 2169], 'harboring': [173, 425], 'amastigotes.': [174, 426], 'Simultaneously,': [175, 427], 'observed': [179, 431, 3334, 3836, 4081, 4147], 'multifold': [181, 433], 'increase': [182, 434, 1961, 4083], 'transcripts': [185, 437], 'as': [186, 233, 438, 485, 537, 1134, 1620, 1783, 2196, 2233, 2340, 3170, 3290, 3292, 3371, 3465, 3518, 3727, 3760, 3812, 3875, 3925, 3983, 4335, 4337], 'promastigote': [188, 440, 671, 3501, 4207, 4225], 'morphs': [194, 446], 'amastigote': [197, 205, 231, 449, 457, 483], 'form.': [198, 450], 'Finally,': [199, 451], 'parasites': [203, 455, 3164, 3376], 'increases': [204, 456], 'survivability': [206, 214, 458, 466, 1711, 1890, 2036, 2118, 2209, 2302], 'within': [207, 459, 1447, 1501, 1823, 2037, 2329], 'whereas': [209, 461, 1937, 3507], 'knocking': [210, 462], 'down': [212, 464], 'reduces': [213, 465], 'drastically.': [215, 467], 'Mice': [216, 468], 'injected': [217, 469], 'their': [219, 471, 877, 3852, 4385], 'footpads': [220, 472], 'an': [222, 474, 712, 1029, 2190, 2221, 2288, 3232, 3694, 3719, 4082, 4273], 'LmATP7-overexpressing': [223, 475], 'strain': [224, 476, 2595, 2615, 3412, 3534, 3548], 'showed': [225, 477, 1494, 1926, 2549, 3176, 3902, 4174], 'significantly': [226, 478, 1495, 2141, 4228], 'larger': [227, 479], 'lesions': [228, 480, 562], 'loads': [232, 484], 'controls': [236, 488, 4232, 4377], 'knockouts.': [238, 490], 'These': [239, 491], 'data': [240, 492, 2548], 'establish': [241, 493, 1748], 'infectivity': [248, 500], 'intramacrophagic': [250, 502], 'survivability.': [251, 503, 3447], 'digenetic': [507], 'protozoan': [508], 'belonging': [509, 1725], 'trypanosomatid': [512], 'group': [513], 'alternates': [515], 'between': [516, 1049, 1055, 1903, 2706, 2761, 2816, 3258, 4347], 'sand': [517, 679, 721], 'fly': [518, 680], 'vector': [519, 3796, 3802, 3864, 4127, 4167, 4205], 'hosts.': [522], 'They': [523, 858], 'cause': [527], 'wide': [529], 'spectrum': [530], 'tropical': [532], 'human': [533, 625, 1677, 2504, 2751, 2806, 2992, 3593, 3806], 'diseases': [534], 'collectively': [535], 'leishmaniasis.': [538], 'The': [539, 824, 957, 1227, 1255, 1327, 1530, 2456, 2522, 2575, 2658, 2831, 2991, 3186, 3448, 3768, 3817, 3869], 'severity': [540], 'disease': [543, 2515, 2941, 3630], 'depends': [544], 'on': [545, 898, 1260, 1285, 1315, 2002, 2034, 2106, 2109, 2676, 2724, 2779, 2911, 2952, 3604, 3970, 4121], 'manifested': [551], 'range': [554, 1902], 'symptoms': [556], 'varies': [558], 'disfiguring': [560], 'skin': [561], 'life-threatening': [564], 'visceral': [568], 'organs': [569], '(1Burza': [570], 'S.': [571, 699, 928, 994, 1008, 1591, 1637, 1666, 3027, 3616, 3648, 3769], 'Croft': [572], 'S.L.': [573, 992], 'Boelaert': [574], 'M.': [575, 642, 651, 884, 2251], 'Leishmaniasis.Lancet.': [576], '2018;': [577], '392:': [578], '951-970Google': [579], 'Scholar).': [580, 667, 733, 800, 857, 956, 1025, 1089, 1121, 1182, 1326, 1385, 1484, 1529, 1608, 1650, 1684, 1877, 2284, 2947, 3087, 3641, 4040], 'With': [581, 1651], 'more': [582, 973, 1199, 1496, 1941, 3274, 3383, 3393, 3550, 3873], 'than': [583, 3277, 3388, 3394, 3535, 3551, 4211, 4230, 4268], 'million': [585, 596], 'new': [586], 'cases': [587], '20,000': [589], '30,000': [591], 'deaths': [592], 'every': [593], 'year,': [594], '12': [595, 940], 'people': [597], 'currently': [599], 'affected': [600], 'about': [602, 2143, 2247, 2553, 3455], '100': [603, 1918], 'endemic': [604], 'countries': [605], 'imposing': [606], 'significant': [608], 'threat': [609], 'global': [612, 659], 'health': [613], 'care': [614], 'system': [615, 1234, 1493], '(2Okwor': [616], 'I.': [617], 'Uzonna': [618], 'J.': [619, 627, 636, 646, 648, 1010, 1244, 1417, 1461, 1506, 1793, 1837, 2257, 2276, 3058, 3083, 3635, 4022], 'Social': [620], 'economic': [622], 'burden': [623, 2139], 'leishmaniasis.Am.': [626], 'Trop.': [628], 'Med.': [629, 796, 952, 1321, 1873], 'Hyg.': [630], '2016;': [631], '94:': [632], '489-493Google': [633], 'Scholar,': [634, 835, 906, 920, 1006, 1250, 1275, 1297, 1363, 1457, 1585, 1833, 1860, 3046], '3Alvar': [635], 'Vélez': [637], 'I.D.': [638], 'Bern': [639], 'C.': [640, 1301, 1305, 1459, 1504, 1567, 1835], 'Herrero': [641], 'Desjeux': [643], 'P.': [644, 701, 2932, 3054], 'Cano': [645], 'Jannin': [647], 'den': [649], 'Boer': [650], 'WHO': [652], 'Leishmaniasis': [653, 656], 'Control': [654], 'Team': [655], 'worldwide': [657], 'estimates': [660], 'incidence.PLoS': [663], 'One.': [664], '2012;': [665, 855, 1118, 1179, 1582, 1647, 3043], '7e35671Google': [666], 'Once': [668], 'flagellated': [670], 'form': [672], 'enters': [675], 'via': [678, 1067], 'bite,': [681], 'they': [682, 761], 'rapidly': [684], 'phagocytosed': [685], '(4Peters': [688], 'N.C.': [689], 'Egen': [690], 'J.G.': [691, 3052], 'Secundino': [692], 'N.': [693, 697, 1601], 'Debrabant': [694], 'A.': [695, 823, 1299, 1635, 3017], 'Kimblin': [696], 'Kamhawi': [698], 'Lawyer': [700], 'Fay': [702], 'M.P.': [703], 'Germain': [704], 'R.N.': [705], 'Sacks': [706, 933], 'D.': [707, 1415, 1791], 'vivo': [709, 3916], 'imaging': [710], 'reveals': [711, 1734], 'neutrophils': [716, 745, 1333, 1349], 'leishmaniasis': [718], 'transmitted': [719], 'flies.Science.': [722], '2008;': [723, 903], '321': [724], '(Erratum': [725], 'in:': [726], 'Science': [727], '2008': [728], 'Dec': [729], '12;322': [730], '(5908):1634):': [731], '970-974Google': [732], 'Phagocytosis': [734], 'occurs': [735], 'either': [736, 3777, 3884], 'directly': [737], 'or': [738, 894, 1626, 1631, 2218, 2335, 3632, 3799, 3804, 3894, 4069, 4131], 'engulfment': [740], 'parasite-harboring': [743], 'apoptotic': [744], 'followed': [746], 'transformation': [748], 'promastigotes': [750, 936, 1742, 2015, 2050, 2199, 3105, 4061, 4133, 4280], 'into': [751, 3683], 'nonflagellated': [752], 'amastigotes': [753, 1751, 2121], 'phagolysosome.': [756], 'Within': [757], 'acidic': [759], 'phagolysosomes,': [760], 'continue': [762], 'proliferate': [764], 'until': [765], 'cell': [767, 1541, 4221, 4327], 'bursts,': [768], 'leading': [769, 3685], 'spread': [772], '(5Chang': [776], 'K.P.': [777, 2930], 'Dwyer': [778], 'D.M.': [779], 'donovani:': [781], 'Hamster': [782], 'macrophage': [783, 852, 899, 1394, 1476, 1502, 1521, 1852, 2038, 2072, 2331], 'vitro:': [786], 'Cell': [787], 'entry,': [788], 'survival,': [790], 'multiplication': [792], 'amastigotes.J.': [794], 'Exp.': [795, 951, 1245], '1978;': [797], '147:': [798], '515-530Google': [799], 'Inside': [801], 'this': [802, 1562, 2008, 2409, 3430, 3443, 3722, 3759, 3906, 3948, 4113], 'compartment,': [803], 'has': [805, 1779, 2068, 2437, 2974, 3589, 3741, 3940, 4006, 4045], 'withstand': [807], 'variety': [809], 'host-induced': [811, 1753], 'stress': [812, 1755, 2328], 'factors,': [813], 'including': [814, 3310], 'free': [815, 1071, 1147], 'radicals,': [816], 'lysosomal': [817], 'hydrolases,': [818], 'low': [820, 1152, 2192, 2232], 'pH': [821], '(6Haas': [822], 'phagosome:': [825], 'Compartment': [826], 'license': [829], 'kill.Traffic.': [831], '2007;': [832, 1681], '8:': [833], '311-330Google': [834], '7Thi': [836], 'E.P.': [837], 'Lambertz': [838], 'U.': [839, 1341, 1365], 'Reiner': [840], 'N.E.': [841], 'Sleeping': [842], 'enemy:': [845], 'How': [846], 'pathogens': [848, 1413], 'cope': [849], 'lifestyle.PLoS': [853], 'Pathog.': [854], '8e1002551Google': [856], 'not': [860, 2076, 3141, 3190, 3456, 3681, 3963, 4070], 'only': [861, 3167, 3457], 'equipped': [862], 'defend': [864], 'such': [866, 2909, 4234], 'harsh': [867], 'environment': [868], 'but': [869, 2074, 3462], 'can': [871, 1060, 1137, 3699, 3921, 3956, 3998], 'manipulate': [872], 'gene': [874, 900, 2592, 2610, 2628, 3431, 3444, 4114], 'benefit': [878], '(8Gregory': [879], 'D.J.': [880, 1078, 1165, 1569], 'Sladek': [881], 'R.': [882, 926, 932, 2255, 2259, 3023], 'Olivier': [883], 'Matlashewski': [885], 'G.': [886, 1303], 'Comparison': [887], 'effects': [890, 1281], 'donovani': [896], 'expression.Infect.': [901], 'Immun.': [902], '76:': [904], '1186-1192Google': [905], '9Beverley': [907], 'S.M.': [908], 'Hijacking': [909], 'cell:': [911], 'Parasites': [912], "driver's": [915], 'seat.Cell.': [916], '1996;': [917, 953, 3084], '87:': [918, 1682], '787-789Google': [919], '10Carrera': [921], 'Gazzinelli': [923], 'R.T.': [924], 'Badolato': [925], 'Hieny': [927], 'Muller': [929], 'W.': [930], 'Kuhn': [931], 'D.L.': [934], 'selectively': [937], 'inhibit': [938], 'interleukin': [939], 'induction': [941], 'bone': [943], 'marrow-derived': [944], 'susceptible': [947, 1200], 'resistant': [949], 'mice.J.': [950], '183:': [954], '515-526Google': [955], 'unavailability': [958], 'vaccine,': [961], 'along': [962], 'increasing': [964, 2123, 4178, 4258, 4332], 'resistance': [965, 998, 1262, 1316, 2217, 4117], 'existing': [968], 'drugs,': [969], 'makes': [970], 'even': [972, 2006, 3392, 4244, 4310], 'important': [974], 'understand': [976], 'physiology': [978], 'molecular': [981], 'mechanisms': [982, 1093], 'allow': [984], 'them': [985], 'thrive': [987], 'inside': [988], '(11Croft': [991], 'Sundar': [993], 'Fairlamb': [995], 'A.H.': [996], 'Drug': [997, 2279], 'leishmaniasis.Clin.': [1000], 'Microbiol.': [1001], 'Rev.': [1002, 1680], '2006;': [1003], '19:': [1004], '111-126Google': [1005], '12Sundar': [1007], 'Jaya': [1009], 'Liposomal': [1011], 'amphotericin': [1012], 'B': [1013, 3148], 'leishmaniasis:': [1015], 'Dose': [1016], 'response.J.': [1018], 'Glob.': [1019], 'Infect.': [1020], 'Dis.': [1021], '2010;': [1022], '2:': [1023, 1875], '159-166Google': [1024], 'micronutrient': [1031], 'biological': [1033], 'system.': [1034], 'Several': [1035], 'enzymes': [1036], 'involved': [1037, 1098, 1534], 'catalyzing': [1039], 'biochemical': [1040], 'processes': [1041], 'utilize': [1042, 1407], 'ability': [1044, 3705], 'cycle': [1048], 'cuprous': [1050], 'cupric': [1052], 'states.': [1053], 'Shuttling': [1054], 'Cu(II)': [1056], 'Cu(I)': [1058], 'states': [1059], 'lead': [1061], 'oxidative': [1063], 'damage': [1064], 'cells': [1066, 2082, 3752, 3861, 4014, 4090, 4299, 4309, 4352], 'Fenton-like': [1068], 'reaction': [1069], 'when': [1070, 2080], 'available': [1074, 2962], '(13Festa': [1075], 'R.A.': [1076], 'Thiele': [1077, 1164, 1568], 'Copper:': [1079], 'An': [1080], 'metal': [1082, 1593, 2422, 2960], 'biology.Curr.': [1084], 'Biol.': [1085, 1116, 1479, 1524, 1855, 3041], '2011;': [1086], '21:': [1087], 'R877-R883Google': [1088], 'Organisms': [1090], 'have': [1091, 1185, 1695, 2407, 2419, 3381, 3977, 4341], 'evolved': [1092], 'where': [1094, 3244], 'several': [1095, 1202], 'proteins': [1096, 3127], 'tightly': [1100], 'regulating': [1101, 1126], 'bioavailability': [1103], '(14Hodgkinson': [1106], 'V.': [1107], 'Petris': [1108, 1466, 1511, 1842], 'M.J.': [1109, 1467, 1512, 1843, 3048], 'homeostasis': [1111, 4001, 4105], 'host-pathogen': [1114], 'interface.J.': [1115], 'Chem.': [1117, 1480, 1525, 1856, 3042], '287:': [1119, 3044], '13549-13555Google': [1120], 'homeostasis,': [1123], 'which': [1124, 1204, 2568, 3658, 3729, 3971, 4242], 'includes': [1125], 'distribution,': [1131], 'crucial': [1133, 3440], 'excess': [1135, 1537, 4192, 4391], 'detrimental.': [1139], 'Cu-binding': [1140], 'proteins,': [1141], 'chaperones,': [1142], 'transporters': [1144], 'keep': [1145], 'very': [1151, 2171], 'level': [1153, 2193, 3461, 3482, 3510, 3526, 4087, 4237], 'order': [1156], '10−18': [1158], 'M': [1159], '(15Nevitt': [1160], 'T.': [1161, 1463, 1508, 1839, 4018], 'Öhrvik': [1162], 'H.': [1163, 4016, 4020], 'Charting': [1166], 'travels': [1168], 'copper': [1170, 1258, 1283, 1313, 1640, 1868, 2386, 2395, 3064, 4034], 'eukaryotes': [1172, 1214, 1616, 1664], 'mammals.Biochim.': [1176], 'Biophys.': [1177], 'Acta.': [1178], '1823:': [1180], '1580-1593Google': [1181], 'Various': [1183], 'studies': [1184, 2858], 'shown': [1186, 2347, 3743, 4008, 4343], 'plays': [1189, 1761], 'key': [1191, 1545, 1763, 2322], 'host–pathogen': [1194], 'interaction.': [1195], 'Cu-deficient': [1196], 'hosts': [1197, 1404], 'pathogens,': [1203], 'include': [1205], 'prokaryotes': [1206], 'like': [1207, 1215, 2239], 'Salmonella': [1208, 1241], 'typhimurium': [1209], 'Pasteurella': [1211, 1268], 'hemolytica,': [1212], 'Candida': [1216], 'albicans': [1217], 'Trypanosoma': [1219, 1318], 'lewisi': [1220], '(16Newberne': [1221], 'P.M.': [1222], 'Hunt': [1223], 'C.E.': [1224, 1424, 1800], 'Young': [1225], 'V.R.': [1226], 'diet': [1230], 'reticuloendothelial': [1233], 'response': [1237], 'rats': [1239], 'typhilmurium': [1242], 'infection.Br.': [1243], 'Pathol.': [1246, 1271], '1968;': [1247], '49:': [1248], '448-457Google': [1249], '17Jones': [1251], 'D.G.': [1252, 1277, 1430, 1806], 'Suttle': [1253, 1278], 'N.F.': [1254, 1279], 'effect': [1256, 1999, 2030, 4190], 'deficiency': [1259, 1284, 1314, 1339, 3688], 'mice': [1264], 'haemolytica.J.': [1269], 'Comp.': [1270], '1983;': [1272], '93:': [1273], '143-149Google': [1274], '18Jones': [1276], 'Some': [1280], 'leucocyte': [1286], 'function': [1287, 1347, 1563, 1720], 'sheep': [1289], 'cattle.Res.': [1291], 'Vet.': [1292], 'Sci.': [1293, 1604], '1981;': [1294], '31:': [1295], '151-156Google': [1296], '19Crocker': [1298], 'Lee': [1300, 1460, 1505, 1836, 4021], 'Aboko-Cole': [1302], 'Durham': [1304], 'Interaction': [1306], 'nutrition': [1308], 'infection:': [1310], 'Effect': [1311], 'lewisi.J.': [1319], 'Natl.': [1320], 'Assoc.': [1322], '1992;': [1323], '84:': [1324], '697-706Google': [1325], 'bactericidal': [1328, 1477, 1522, 1853], 'activity': [1329, 1372, 2458, 4277], 'impaired': [1336, 1377], '(20Babu': [1340], 'Failla': [1342, 1366], 'M.L.': [1343, 1367], 'status': [1345], 'reversibly': [1351], 'depressed': [1352], 'marginally': [1354], 'severely': [1356], 'copper-deficient': [1357, 1379], 'rats.J.': [1358, 1380], 'Nutr.': [1359, 1381], '1990;': [1360, 1382], '120:': [1361, 1383], '1700-1709Google': [1362], '21Babu': [1364], 'Respiratory': [1368], 'burst': [1369], 'candidacidal': [1371], 'peritoneal': [1374], '1692-1699Google': [1384], 'Similarly,': [1386], 'channelization': [1388], 'phagosomal': [1391], 'compartment': [1392], 'during': [1395, 2333], 'Mycobacterium': [1396, 1436, 1438, 1441, 1812, 1814, 1817], 'avium': [1397], 'Escherichia': [1399], 'coli': [1400, 1486], 'indicated': [1402, 2211], 'how': [1403], 'tend': [1405], 'fight': [1410], 'off': [1411], '(22Wagner': [1414, 1790], 'Maser': [1416, 1792], 'Lai': [1418, 1794], 'B.': [1419, 1795], 'Cai': [1420, 1796], 'Z.': [1421, 1797], 'Barry': [1422, 1798], '3rd,': [1423, 1799], 'Höner': [1425, 1801], 'Zu': [1426, 1802], 'Bentrup': [1427, 1803], 'K.': [1428, 1465, 1510, 1804, 1841, 2253], 'Russell': [1429, 1805], 'Bermudez': [1431, 1807], 'L.E.': [1432, 1808], 'Elemental': [1433, 1809], 'analysis': [1434, 1810], 'avium-,': [1437, 1813], 'tuberculosis-,': [1439, 1815], 'smegmatis-containing': [1442, 1818], 'phagosomes': [1443, 1819], 'indicates': [1444, 1820, 4272], 'pathogen-induced': [1445, 1821], 'microenvironments': [1446, 1822], "cell's": [1450, 1826], 'endosomal': [1451, 1827], 'system.J.': [1452, 1828], 'Immunol.': [1453, 1829], '2005;': [1454, 1830], '174:': [1455, 1831], '1491-1500Google': [1456, 1832], '23White': [1458, 1834], 'Kambe': [1462, 1507, 1838], 'Fritsche': [1464, 1509, 1840], 'A': [1468, 1513, 1844, 3077, 3252], 'copper-transporting': [1473, 1518, 1678, 1849, 3034], 'ATPase': [1474, 1519, 1700, 1850, 2271, 2366, 2411, 2973, 3035, 3066, 3933], 'activity.J.': [1478, 1523, 1854], '2009;': [1481, 1526, 1857], '284:': [1482, 1527, 1858], '33949-33956Google': [1483, 1528, 1859], 'E.': [1485, 3019], 'mutant': [1487, 3411, 3611, 3677, 3723, 3751, 3772], 'defective': [1490], 'exporting': [1492, 1536], 'susceptibility': [1497], 'Cu-mediated': [1499, 4119], 'killing': [1500], '(23White': [1503], 'P-type': [1531, 2365, 2396, 2880, 3065, 3594, 3644, 3766, 3927], 'Cu-ATPases': [1532, 1558, 2460, 2906, 2988], 'players': [1546], 'maintaining': [1548, 3458, 4102], 'homeostasis.': [1550], 'bacteria,': [1552], 'CopA': [1553, 2694], 'CopB': [1555], 'carry': [1560], 'out': [1561, 1659, 3570], '(24Samanovic': [1564], 'M.I.': [1565], 'Ding': [1566], 'Darwin': [1570], 'K.H.': [1571], 'microbial': [1574], 'pathogenesis:': [1575], 'Meddling': [1576], 'metal.Cell': [1579], 'Host': [1580], 'Microbe.': [1581], '11:': [1583, 2945], '106-115Google': [1584], '25Argüello': [1586], 'J.M.': [1587], 'Mandal': [1588], 'A.K.': [1589], 'Mana-Capelli': [1590], 'Heavy': [1592], 'CPx-ATPases': [1595], 'thermophile': [1598], 'Archaeoglobus': [1599], 'fulgidus.Ann.': [1600], 'Y.': [1602], 'Acad.': [1603], '2003;': [1605], '986:': [1606], '212-218Google': [1607], 'There': [1609, 2159], 'single': [1612, 3793], 'lower': [1615, 4210], '(nonchordates)': [1617], 'referred': [1618], 'Ccc2p': [1621], 'Saccharomyces': [1624], 'cerevisiae': [1625, 3617, 3770], 'ATP7': [1627, 1661], 'Drosophila': [1629], 'melanogaster': [1630], 'simply': [1632], '(26Gupta': [1634], 'Lutsenko': [1636, 3026], 'Evolution': [1638], 'transporting': [1641, 3568], 'ATPases': [1642, 2397, 2881, 2888, 2961], 'eukaryotic': [1644], 'organisms.Curr.': [1645], 'Genomics.': [1646], '13:': [1648], '124-133Google': [1649], 'increased': [1652], 'complexity,': [1653], 'ATP7B': [1656, 2506, 2752, 2996, 3036, 3807], 'branched': [1658], '(27Lutsenko': [1665], 'Barnes': [1667], 'N.L.': [1668], 'Bartee': [1669], 'M.Y.': [1670], 'Dmitriev': [1671, 3024], 'O.Y.': [1672, 3025], 'Function': [1673], 'regulation': [1675, 4026, 4050, 4292], 'ATPases.Physiol.': [1679], '1011-1046Google': [1683], 'present': [1687, 2295], 'study,': [1688, 3949], 'using': [1689, 1758, 2200, 2539, 3415], 'cell-based': [1690, 3945], 'mouse': [1692], 'models,': [1693], 'functionally': [1696, 3912, 3923], 'Cu-transporting': [1699, 2364, 2589, 3932], '(LmATP7)': [1701, 2367], 'determined': [1706, 2969, 4072], 'leishmanial': [1710, 2972, 3907], 'macrophage.': [1714], 'Our': [1715, 3421], 'study': [1716, 1733], 'establishes': [1717], 'physiological': [1719], 'full-length': [1723], 'Kinetoplastida': [1728], 'order.': [1729], 'addition,': [1731], 'our': [1732, 2104, 2612, 3199, 4370], 'protective': [1736], 'combat': [1752], 'lysosomes': [1757, 2332], 'pathogenicity,': [1768], 'establishment': [1769], 'host,': [1772], 'successful': [1774], 'manifestation': [1775], 'infection.': [1777], 'been': [1780, 3590, 3742, 3941, 4007], 'conventionally': [1781], 'used': [1782, 2408, 2664, 3584, 3942], 'chemotherapeutic': [1785], 'agent': [1786], 'parasitic': [1788], 'infections': [1789], '28Dollwet': [1861], 'H.H.A.': [1862], 'Sorenson': [1863], 'J.R.J.': [1864], 'Historic': [1865], 'uses': [1866], 'compounds': [1869], 'medicine.Trace': [1871], 'Elem.': [1872], '1985;': [1874], '80-87Google': [1876], 'To': [1878, 3088, 3197, 3574, 4041, 4110], 'explore': [1879], 'if': [1880, 2311, 3090, 3368, 3576, 3995, 4043, 4112], 'lethality': [1881], 'could': [1882, 2075, 3304, 3453, 4243], 'induced': [1884], 'parasites,': [1887, 4123], 'tested': [1889, 2341], 'growth': [1895, 1932, 2055, 2073, 3824, 3853, 4150, 4176, 4254, 4266, 4346, 4386], 'media': [1896, 3830], 'supplemented': [1897, 2053], '0': [1904, 2058, 2086, 2094, 4138, 4153, 4361], '500': [1906, 1978, 2060, 2088, 2147, 4140, 4197, 4246, 4363], 'μM': [1907, 1919, 1954, 1979, 2061, 2089, 2134, 2148, 3321, 4064, 4141, 4198, 4247, 4322, 4364], '24,': [1909], '48,': [1910], '72': [1912, 1944, 1968, 2022, 4155, 4354], 'h': [1913, 1945, 1969, 1994, 2023, 2097, 2156, 3318, 4068, 4156, 4186, 4218, 4355], 'postincubation.': [1914, 4157], 'At': [1915], '50': [1916, 2133, 3320, 4063, 4321], 'external': [1921, 1981, 2032, 2091, 2149, 2173, 4143, 4201, 4249, 4392], 'concentration,': [1923, 1957, 2011], 'gradual': [1928], 'decline': [1929, 2163], 'starting': [1933, 1991, 2131, 4183, 4319], '24': [1935, 1966, 1993, 2155, 4185, 4217], 'h,': [1936], 'trend': [1939, 2116, 2210], 'was': [1940, 1959, 2160, 2569, 2691, 2735, 2741, 2790, 2796, 3128, 3155, 3181, 3202, 3256, 3475, 3498, 3527, 3773, 3809, 3845, 3909, 4227], 'drastic': [1942], 'postincubation': [1946, 1970, 1995, 2024, 4356], '(Fig.': [1947, 2025, 2098, 2176, 2520, 2566, 2989, 3106, 3120, 3146, 3195, 3220, 3282, 3348, 3523, 3540, 3917, 4169], '1A).': [1948, 2026], 'Importantly,': [1949, 3900, 4297], '200': [1951], '300': [1953], 'there': [1958, 3354], 'no': [1960, 3356], 'count': [1964, 4226, 4328], 'initial': [1974, 4213], 'inoculum.': [1975], 'However,': [1976, 2100, 2178, 3717], 'supplementation,': [1983], 'number': [1986, 2013, 4215], 'gradually': [1987, 4256, 4330], 'decreased': [1988, 2140, 4255, 4329], 'time': [1990, 3210, 3234, 3265, 3270, 3280, 3328, 4240], 'toxic': [1998], 'parasite.': [2004], 'Interestingly,': [2005, 4076, 4223], 'high': [2009, 2172, 2984, 3253, 3336], 'remained': [2016], 'almost': [2017], 'same': [2018], '48': [2020, 2096], 'evaluated': [2028, 3822], 'cells.': [2039, 3716], 'For': [2040, 2721, 2776], 'this,': [2041], 'first': [2043], 'infected': [2044, 2168], 'J774A.1': [2045, 2081], 'then': [2052, 3375, 3659], 'medium': [2056, 4182], 'Cu.': [2063, 2306, 4193, 4317], 'checked': [2065], 'whether': [2066], 'any': [2069, 2078, 2316, 3192, 4116], 'toxicity': [2070, 2108, 4120], 'over': [2071], 'find': [2077], 'alteration': [2079], 'were': [2083, 2530, 2852, 3821, 4091, 4209, 4378], 'treated': [2084, 4092], 'S1).': [2099], 'line': [2102, 3407], 'observation': [2105], 'Cu-induced': [2107], 'similar': [2115, 3343], 'concentration.': [2125], 'As': [2126, 4158], 'evident': [2127, 4159, 4282], 'Figure': [2129, 4161, 4373], '1B,': [2130], 'Cu,': [2136, 4094, 4202, 4393], 'threefold': [2144, 3529, 3552], 'reduction': [2145], 'untreated': [2153], 'control': [2154, 3163, 3171, 3815, 3865, 4128, 4168, 4206], 'postinfection': [2157], '(p.i.).': [2158], 'slight': [2162], 'percentage': [2166, 2703, 2758, 2813], 'concentrations': [2175], '1C).': [2177], 'given': [2179], 'internal': [2182, 2243, 3459, 4290], 'maintained': [2188, 4263], 'extremely': [2191], '(∼3–4': [2194], 'ppb': [2195, 2249], 'measured': [2197], 'inductively': [2201], 'coupled': [2202], 'optical': [2204], 'emission': [2205], 'spectrometry': [2206], '[ICP–OES]),': [2207], 'extent.': [2223], 'Internal': [2224], 'content': [2226], 'relatively': [2231, 4288], 'other': [2236, 3544, 3944], 'protozoa': [2238], 'Naegleria': [2240, 2267], 'fowleri': [2241, 2268], 'whose': [2242, 2501], 'amounts': [2245], '84.1': [2248], '(29Grechnikova': [2250], 'Ženíšková': [2252], 'Malych': [2254], 'Mach': [2256], 'Sutak': [2258], 'detoxification': [2261], 'machinery': [2262, 2292], 'brain-eating': [2265], 'amoeba': [2266], 'involves': [2269], 'copper-translocating': [2270], 'antioxidant': [2274], 'system.Int.': [2275], 'Parasitol.': [2277, 2402], 'Drugs': [2278], 'Resist.': [2280], '2020;': [2281, 2403], '14:': [2282], '126-135Google': [2283], 'argue': [2286], 'efficient': [2289, 3384], 'handling': [2291], 'must': [2293], 'confers': [2300], 'elevated': [2304], 'nonphysiological': [2305], 'attempted': [2308], 'identify': [2310], 'genome': [2313, 2370], 'encodes': [2314], 'exporter': [2318], 'might': [2320], 'artificial': [2337], 'experimental': [2338], 'condition': [2339, 3347], 'previous': [2344, 3739], 'section': [2345], '(as': [2346], 'Fig.': [2349, 3173, 4284], '1,': [2350], 'A–C).': [2351], 'Upon': [2352, 3316], 'scanning': [2353], 'kinetoplastid': [2355], 'informatics': [2356], 'resources,': [2357], 'TriTrypDB,': [2358], 'came': [2360], 'across': [2361, 2923], 'putative': [2363, 2588, 2648], 'major.': [2373, 3936], 'Previously,': [2374], 'Isah': [2375], 'et': [2376], 'al.': [2377], '(30Isah': [2378], 'M.B.': [2379], 'Goldring': [2380], 'J.P.D.': [2381], 'Coetzer': [2382], 'T.H.T.': [2383], 'Expression': [2384], 'binding': [2387], 'N-': [2391], 'terminal': [2392, 2981], 'domain': [2393, 2447, 2496, 2748, 2803], 'African': [2399], 'trypanosomes.Mol.': [2400], 'Biochem.': [2401], '235:': [2404], '111245Google': [2405], 'Scholar)': [2406], 'particular': [2410], 'phylogenetic': [2413], 'analysis.': [2414], 'It': [2415, 2436], 'predicted': [2417], 'three': [2420, 2647, 2662], 'heavy': [2421], '(HM)-binding': [2423], 'domains': [2424, 2663, 2958], 'N-terminal': [2427, 2903], 'region,': [2428], 'each': [2429], 'containing': [2430, 2483, 2897], 'characteristic': [2432, 2975], 'Cu+-binding': [2433, 2976], 'motif,': [2434], 'CXXC.': [2435], 'highly': [2439], 'conserved': [2440, 2472, 2487, 2653], 'TGE': [2441], 'sequence': [2442, 2450, 2605, 2623, 2659, 2704, 2759, 2814], 'actuator': [2445], '(A)': [2446], 'DKTGT': [2449, 2473], 'phosphorylation': [2453, 2464], '(P)': [2454], 'domain.': [2455, 2904], 'catalytic': [2457], 'through': [2463, 2936], 'dephosphorylation': [2466], 'Asp': [2468], 'residue': [2469], 'motif.': [2474], 'comprised': [2478], 'hydrolase': [2481], 'region': [2482], 'TGDN': [2484], 'GXGXND': [2486], 'motifs': [2488, 2650, 2899, 2910], 'ATP-binding': [2491], 'site': [2492], 'nucleotide-binding': [2495], 'SXHP': [2499], 'motif': [2500, 2655, 2916], 'mutation': [2502, 3631, 3748, 3850], 'ortholog': [2505], '(His1069Gln)': [2507], 'most': [2510], 'frequent': [2511], 'contributor': [2512], "Wilson's": [2514], 'Caucasian': [2518], 'population': [2519, 3502, 3517], '1D).': [2521], 'genomic': [2523, 2558], 'DNA': [2524, 2535, 2559, 2580], 'RNA': [2526], 'isolated': [2531], 'amplified': [2533], '(complementary': [2534], '[cDNA]': [2536], 'RNA)': [2538], 'primers': [2540], 'designed': [2541], 'amplify': [2543], 'LmATP7.': [2545, 2657], 'Gel': [2546], 'electrophoresis': [2547], 'fragment': [2551, 2581], '3500': [2554], 'bp': [2555], 'cDNA,': [2561], 'transcriptional': [2564], '1E),': [2567], 'subsequently': [2570], 'confirmed': [2571, 3499], 'Sanger': [2573], 'sequencing.': [2574], 'sequencing': [2576], 'result': [2577], 'revealed': [2578], '3492': [2583], 'bp,': [2584], 'identical': [2585, 2602], 'ATPase-like': [2590], 'protein-encoding': [2591], '(L.': [2593], 'Friedlin;': [2596], 'GeneID:': [2597], '5654633).': [2598], 'Although': [2599, 4252], 'encoded': [2601], 'amino': [2603, 2913], 'acid': [2604], '(1163': [2606], 'length),': [2608], '5ASKH': [2616], 'differed': [2617], 'six': [2619, 2908], 'nucleotides': [2620], 'Friedlin': [2625], 'Both': [2627, 3558, 4375], 'mRNA': [2630], 'sequences': [2631], 'submitted': [2635], 'GenBank': [2638], '(accession': [2639], 'numbers:': [2640], 'MW261996': [2641], 'MW261995,': [2643], 'respectively).': [2644], 'detected': [2646], 'HM': [2649, 2957], 'Cys-X-X-Cys': [2654, 2898], 'modeling': [2667, 2688, 2740, 2795, 2950], 'included': [2669], 'Experimental': [2672], 'procedures': [2673], 'section.': [2674], 'Based': [2675], 'E': [2678, 2727, 2782], 'value': [2679, 2728, 2783], 'alignment': [2681, 2718, 2730, 2773, 2785, 2828], '(0.65E−04),': [2682], 'template': [2684, 2708, 2733, 2763, 2788, 2818], 'chosen': [2685], 'HM1': [2690], 'Bacillus': [2692], 'subtilis': [2693], '(Protein': [2695], 'Data': [2696], 'Bank': [2697], '[PDB]': [2698], 'ID:': [2699, 2754, 2809], '1OPZ),': [2700], 'identity': [2705, 2760, 2815], 'model': [2711, 2766, 2821], 'normalized': [2712, 2767, 2822], 'lengths': [2715, 2770, 2825], 'being': [2719, 2774, 2829], '30.': [2720], 'HM2,': [2722, 2848, 2872], 'based': [2723, 2778, 2951, 3603], 'lowest': [2726, 2781, 2836], '(0.32E−06),': [2731], 'suitable': [2737, 2792], 'solution': [2743, 2798], 'structure': [2744, 2799], 'metal-binding': [2747, 2802], '4': [2749], '(PDB': [2753, 2808], '2ROP)': [2755], '36.': [2775], 'HM3,': [2777, 2850], '(0.68E−04),': [2786], '6': [2804], '1YJV)': [2810], '46.': [2830], 'modeled': [2832], 'structures': [2833, 2953], 'Discrete': [2837], 'Optimization': [2838], 'Protein': [2839], 'Energy': [2840], 'score': [2841], '−4818.916016,': [2843], '−4788.835449,': [2844], '−5403.311035': [2845], 'HM1,': [2847, 2866], 'respectively,': [2851], 'selected': [2853], 'validations': [2855], 'simulation': [2857], '(Figs.': [2859, 3417, 4106], '1F,': [2860], 'S2,': [2861, 2867, 2874], 'A1': [2862], 'A2': [2864], 'B1': [2868], 'B2': [2870], 'C1': [2875], 'C2': [2877], 'HM3).': [2879], 'class': [2884, 3930], 'IB': [2885, 3931], 'HM-transporting': [2887], 'unique': [2892], 'presence': [2893, 4136, 4359], 'HM-binding': [2895], 'sites': [2896], 'cytosolic': [2902], 'Mammalian': [2905], 'harbors': [2907], 'terminus.': [2914], 'sequesters': [2917], 'facilitates': [2920], 'membrane': [2925, 3010, 3096, 3117, 3230, 3289, 3655], 'lumen': [2928], '(31Shanmugavel': [2929], 'Wittung-Stafshede': [2931], 'relay': [2934], 'path': [2935], 'N-terminus': [2938], 'Wilson': [2940, 3629], 'protein,': [2942], 'ATP7B.Metallomics.': [2943], '2019;': [2944], '1472-1480Google': [2946], 'Using': [2948], 'amino-terminal': [2956], 'protein': [2965, 3379, 3908, 3997], 'database': [2966], '(PDB),': [2967], 'pockets': [2977], 'N': [2980], 'share': [2983], '1F).': [2990], 'localize': [2997, 3142], '(TGN)': [3002], 'traffic': [3004], 'vesicles': [3006, 3249], 'treatment': [3013, 4005], '(32Hasan': [3014], 'N.M.': [3015], 'Gupta': [3016], 'Polishchuk': [3018, 3022], 'Yu': [3020], 'C.H.': [3021], 'Molecular': [3028], 'events': [3029], 'initiating': [3030], 'exit': [3031], 'network.J.': [3040], '36041-36050Google': [3045], '33Petris': [3047], 'Mercer': [3049], 'J.F.': [3050], 'Culvenor': [3051], 'Lockhart': [3053], 'Gleeson': [3055], 'P.A.': [3056], 'Camakaris': [3057], 'Ligand-regulated': [3059], 'Menkes': [3063], 'efflux': [3067], 'pump': [3068], 'Golgi': [3071], 'apparatus': [3072], 'membrane:': [3076], 'regulated': [3081], 'trafficking.EMBO': [3082], '15:': [3085], '6084-6095Google': [3086], 'determine': [3089, 3205, 3478, 3575, 4042], 'localizes': [3092], 'cloned': [3100], 'expressed': [3102, 3781, 3811, 3979], 'LmATP7-GFP': [3103, 3138, 3151, 3206], '2A)': [3107, 3174], 'colabeled': [3109], 'bona': [3113, 3580], 'fide': [3114, 3581], 'Leishmania-specific': [3115], 'marker': [3118, 3145, 3260], 'GP63': [3119], '2B).': [3121], 'High': [3122], 'colocalization': [3123, 3254, 3342], 'two': [3126, 3209, 3890], 'observed,': [3129], 'small': [3132], 'fraction': [3133], 'puncta': [3136, 3303], 'did': [3140, 3189, 3962], '2,': [3147, 3221, 3349], 'C).': [3150], 'staining': [3152], 'anti-GFP': [3154], 'specific': [3156], 'distinct': [3158], 'overexpressed': [3166, 3505], 'GFP': [3168, 3193, 3954, 3961], '(mentioned': [3169], 'nonspecific': [3178], 'signal': [3179, 3194], 'distributed': [3182], 'throughout': [3183, 4238], 'cell.': [3185, 3573], '2A).': [3196], 'substantiate': [3198], 'findings,': [3200], 'FM4-64FX': [3201, 3225], 'utilised': [3203], 'localization': [3207, 3295, 3361, 3969], 'points': [3211], 'dye': [3214, 3226, 3341], 'uptake,': [3215, 3332], '1': [3216, 3278], '10': [3218, 3268, 3326], 'min': [3219, 3269, 3279, 3327], 'D': [3222], 'E).': [3224], 'labels': [3227, 3246], 'early': [3233], 'point': [3235, 3271, 3281, 3329], '(1': [3236], 'min),': [3237], 'time,': [3240], 'endocytosed': [3243], '(10': [3250], 'min).': [3251], 'coefficient': [3255], 'recorded': [3257], 'transporter': [3262, 3646], 'points,': [3266, 4241], 'showing': [3272], 'statistically': [3273], 'marker–transporter': [3275], 'association': [3276], '2E).': [3283], 'suggestive': [3286, 3561], 'well': [3291, 3701, 4336], 'endocytic': [3293], 'vesicular': [3294], 'protein.': [3298], 'account': [3305], 'secretory': [3308], 'functions,': [3309], 'delivery': [3312], 'Cu-requiring': [3314, 3470], 'proteins.': [3315, 3473], '2': [3317, 4067], 'treatment,': [3323, 4325], 'FM4-64': [3331], 'persistence': [3337], 'basal': [3345], 'F': [3350], 'G),': [3352], 'change': [3358], 'treatment.': [3364], 'hypothesized': [3366], 'functions': [3370], 'transporter,': [3374], 'should': [3380], 'deletion': [3397, 3489, 3516, 3610, 3676], 'counterpart.': [3398], 'successfully': [3400], 'generated': [3401], 'GFP-tagged': [3403, 3938], '(LmATP7-OE)': [3406], 'pXG-NEO': [3416], '3A': [3418], 'S3A).': [3420], 'repeated': [3422], 'attempts': [3423], 'develop': [3425], 'complete': [3427], 'failed,': [3435], 'strongly': [3436, 3874], 'indicative': [3437], 'nature': [3450], 'acting': [3464], 'supplier': [3468], 'ICP–OES': [3474], 'performed': [3476], 'Wt,': [3484, 4055, 4126, 4348], 'LmATP7-OE,': [3485, 4056, 4130, 4349], '(LmATP7-Het)': [3490], 'promastigotes.': [3493], 'Higher': [3494], 'stably': [3504], 'GFP-LmATP7,': [3506], 'transcript': [3509, 4074, 4086], 'dropped': [3511], 'half': [3513], '3A).': [3524], 'approximately': [3528], 'less': [3530], 'LmATP7-OE': [3533, 4224, 4279], '3B).': [3541], 'On': [3542], 'hand,': [3545], 'LmATP7-Het': [3547, 4058, 4132, 4298, 4351], 'accumulated': [3549], 'Wt.': [3557], 'results': [3559], 'functional': [3586, 3605, 3763, 3898], 'assay': [3587, 3601, 3764], 'developed': [3591], 'Cu-ATPases,': [3595], 'ATP7A/B': [3596], 'mutants.': [3599], 'complementation': [3606], 'CCC2': [3609, 3914, 3958], '(ccc2Δ)': [3612], '(34Forbes': [3618], 'J.R.': [3619], 'Cox': [3620], 'D.W.': [3621], 'Functional': [3622], 'characterization': [3623], 'missense': [3625], 'mutations': [3626], 'ATP7B:': [3628], 'normal': [3633], 'variant?.Am.': [3634], 'Hum.': [3636], 'Genet.': [3637], '1998;': [3638], '63:': [3639], '1663-1674Google': [3640], 'Ccc2p,': [3642], 'cerevisiae,': [3649], 'transports': [3650], 'oxidase': [3656], 'Fet3p,': [3657, 3684], 'works': [3660], 'high-affinity': [3663, 3690], 'iron': [3664, 3669, 3691, 3708, 3713], 'importer': [3665], 'Ftr1p': [3666], 'import': [3668], 'medium.': [3672, 3857], 'ccc2Δ,': [3678], 'incorporated': [3682], 'uptake.': [3692], 'iron-sufficient': [3695, 3828], 'medium,': [3696, 3721, 3757], 'ccc2Δ': [3698, 3747, 3771, 3844], 'grow': [3700, 3726, 3754, 4302], 'owing': [3702], 'low-affinity': [3707], 'uptake': [3709, 3989], 'systems': [3710], 'supply': [3712], 'iron-limited': [3720, 3756, 3856], 'fails': [3724], 'Fet3p-Ftr1p,': [3728], 'under': [3732, 4390], 'these': [3733], 'conditions,': [3734, 4260], 'nonfunctional.': [3736], 'ATP7B,': [3737], 'studies,': [3740], 'complement': [3745, 3848, 3913, 3957], 'allowing': [3749, 4286], 'establishing': [3758], 'convenient': [3762], 'Cu-ATPases.': [3767], 'accordingly': [3774], 'transformed': [3775], 'GFP-LmATP7': [3780, 3842, 3880], 'downstream': [3782], 'strong': [3785], 'TEF': [3786], '(Translation': [3787], 'Elongation': [3788], 'Factor)': [3789], 'promoter': [3790], 'copy': [3794], 'centromeric': [3795], '(p416TEF-LmATP7,': [3797], 'p416TEF-GFPLmATP7)': [3798], 'empty': [3801], 'pTEF416': [3803], 'similarly': [3810], 'positive': [3814], '(p416TEF-ATP7B).': [3816], 'transformants': [3818], 'appeared': [3820], 'iron-deficient': [3826], '(control)': [3829], 'serial': [3832], 'dilution': [3833], 'assay.': [3834], 'able': [3846, 3910, 4380], 'restoring': [3851], 'contrast,': [3859], 'bearing': [3862], 'failed': [3866], 'grow.': [3868], 'p416TEF-ATP7B': [3870], 'construct': [3871], 'complemented': [3872], 'may': [3882], 'reflect': [3883], 'difference': [3885], 'genes': [3891], 'possible': [3895, 4097], 'differences': [3896], 'efficiency.': [3899], 'complementation,': [3903], '3C).': [3918], 'Hence,': [3919], 'ascertained': [3924], 'Since': [3937, 3975], 'experiments': [3946], 'ensured': [3951], 'chimera': [3955], 'interfere': [3964], 'correct': [3967], 'functioning': [3973], 'depends.': [3974], 'ectopically': [3978], 'capable': [3986], 'yeast,': [3991], 'now': [3993], 'investigated': [3994], 'regulate': [3999], 'Leishmania.': [4003], 'upregulate': [4010], '(35Chun': [4015], 'Catterton': [4017], 'Kim': [4019, 4023], 'B.E.': [4024], 'Organ-specific': [4025], 'abundance': [4029], 'coordinated': [4031], 'systemic': [4033], 'homeostasis.Sci.': [4035], 'Rep.': [4036], '2017;': [4037], '7:': [4038], '12001Google': [4039], 'challenged': [4054], 'levels.': [4075], 'cases,': [4079], 'while': [4088], '4A': [4107], 'S3B).': [4109], 'verify': [4111], 'imparts': [4115], 'grew': [4125], '(GFP-only),': [4129], 'systematically': [4146], 'kinetics': [4151], '4,': [4162], 'B–D,': [4163], 'S3C)': [4170], 'strains': [4173], 'reduced': [4175, 4294], 'postincubation,': [4187, 4219], 'cytotoxic': [4189, 4295], 'fact,': [4195], 'concentration': [4199, 4334, 4367], 'counts': [4208], 'seeded': [4214], 'death.': [4222], 'heightened': [4235], 'tolerate': [4245], 'consistently': [4262], 'rate': [4267, 4306], 'controls.': [4270], 'enhanced': [4274], '(also': [4281], '3B),': [4285], 'better': [4289], 'effects.': [4296], 'struggled': [4300], 'comparable': [4305], 'absence': [4313], 'externally': [4315], 'added': [4316], 'Also,': [4318], 'time.': [4339], 'illustrated': [4369], 'findings': [4371], '4E.': [4374], 'survive': [4382], 'maintain': [4384], 'some': [4388], 'extent': [4389], 'p': [4394]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4200494997', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-17T07:45:28.803988', 'created_date': '2021-12-31'}
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