Title: Stereo-EEG features of focal cortical dysplasia type II
Abstract: Objective
To search for biological markers closely related to seizure frequency and the location of the epileptic zone by comparing the waveform characteristics of stereo-EEG (SEEG) of two pathological types (type Ⅱa and type Ⅱb) in focal cortical dysplasia (FCD).
Methods
Thirty one patients with FCD implanted the stereotactic electrodes at the Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical University from January 2012 to January 2015 were analyzed retrospectively. The differences of the waveform characteristics and the response of cortical electrical stimulation in patients with type Ⅱa and type Ⅱb in the SEEG intermittent period (awaking period), before seizures, seizures period, and after seizures were compared, and the accuracy of the multiple parameter criteria of the combined waveform characteristics in each period and the low voltage fast activities (LVF) for localization of the epileptic zone were compared.
Results
There were no significant differences in SEEG waveform characteristics in each period between the patients with FCD type Ⅱa and FCD type Ⅱb(all P<0.05). The patients with FCD type Ⅱ whose duration of continuous epileptic discharge (CED) was long (P=0.046) and the distribution of discharge was wide (P=0.044) had higher seizure frequencies.
Conclusions
The effect of the pathologic typing of FCD type Ⅱ on the waveform characteristics of four periods during SEEG monitoring and seizure frequencies is not significant. The intermittent period CED may be a biological marker for assessment of the efficacy of FCD type Ⅱ. This index combined with multi-parameter criteria may be more accurate compared with the single application of LVF for the location of epileptogenic zone.
Key words:
Epilepsy; Focal cortical dysplasia; Electroencephalography; Stereo-electroence-phalography
Publication Year: 2016
Publication Date: 2016-08-28
Language: en
Type: article
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