Title: Progress in the research of smallpox vaccines
Abstract:In the last decade, the research on smallpox vaccine has been paid much more attention because of the special position of variola virus in bioterrorism and biological warfare. To date, 4 generations o...In the last decade, the research on smallpox vaccine has been paid much more attention because of the special position of variola virus in bioterrorism and biological warfare. To date, 4 generations of smallpox vaccines have been developed, and of which 3 generations can be used. Among them, the first generation smallpox vaccines play an important role in the achievement of global smallpox eradication, but their adverse reactions are strong. The second generation smallpox vaccines possess the theoretical advantages conferred by improved manufacturing process and lowered risk of contamination by adventitious agents. The third generation smallpox vaccines have reduced virulence and improved safety, but the immunological efficacy has also descended. The fourth generation smallpox vaccines are developed by techniques for genetic engineering, and the efficacy remains to be evaluated. Owing to global smallpox eradication, the evaluation of the immunological efficacy of new smallpox vaccines becomes the key procedure which can hinder the development of new vaccines.
Key words:
Smallpox vaccine; Vaccine, attenuated; Virus replication; Drug evaluationRead More
Publication Year: 2010
Publication Date: 2010-12-10
Language: en
Type: article
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Cited By Count: 1
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