Title: Subtotal splenectomy for splenomegaly: a study on the distribution and the quantity of fibrous tissue in the remnant spleen
Abstract: Objective To investigate the changes in collagen,elastic and reticular fibers in the splenic remnant after subtotal splenectomy for splenomegaly,and to study for the basis for spleenpreservation technique for this condition.Methods We studied 13 patients with splenomegaly due to portal hypertension.The specimens were obtained by operation and puncturing biopsy,and they were divided into the splenomegaly group and the splenic remnant group.The control group consisted of 13 patients with traumatic splenic rupture.Using Masson staining,EVG staining,and Silver staining,the samples were analyzed using light microscopy after staining.Results The relative contents of collagen fibers (RCC),elastic fibers (RCE),and reticular fibers (RCR) in the splenic remnant,the splenomegaly,and the normal spleen were (7.81 ±0.83)%,(7.72± 3.42)%,(4.67 ± 1.09)%;(7.76±0.81)%,(7.21±3.18)%,(4.79±1.20) % ; (3.21±0.51)%,(1.67±3.22)%,(10.92±0.86)%,respectively.There was no difference between the splenomegaly and the splenic remnant for the three kinds of fiber content (P>0.05).Significantly higher numbers of collagen and elastic fibers were observed in the control group when compared with the splenic remnant and the splenomegaly groups (P<0.05).Significantly lower numbers'of reticular fibers were observed in the splenic remnant and the splenomegaly groups when compared with the control group (P< 0.05).Conclusions As the remnant spleens were fixed in retropertoneum after subtotal splenectomy,there could not be excessive fibrosis in the splenic tissues.
Key words:
Spleen; Pathology; Splenectomy
Publication Year: 2013
Publication Date: 2013-03-28
Language: en
Type: article
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