Publication Information

{'id': 'https://openalex.org/W3028659035', 'doi': 'https://doi.org/10.3760/cma.j.issn.2095-428x.2019.07.007', 'title': 'Effect of antibiotic-induced microbiota dysbiosis on colonic mucosal barrier and immune response in juvenile mice', 'display_name': 'Effect of antibiotic-induced microbiota dysbiosis on colonic mucosal barrier and immune response in juvenile mice', 'publication_year': 2019, 'publication_date': '2019-04-05', 'ids': {'openalex': 'https://openalex.org/W3028659035', 'doi': 'https://doi.org/10.3760/cma.j.issn.2095-428x.2019.07.007', 'mag': '3028659035'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://rs.yiigle.com/CN101070201907/1130224.htm', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086536116', 'display_name': 'Hongwei Guo', 'orcid': 'https://orcid.org/0000-0002-4046-2643'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongwei Guo', 'raw_affiliation_strings': ['Department of Pediatrics, Tangdu Hospital, Air Force Military Medical University, Xi′an 710038, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Tangdu Hospital, Air Force Military Medical University, Xi′an 710038, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026048973', 'display_name': 'Nini Zhang', 'orcid': 'https://orcid.org/0000-0002-9314-7348'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nini Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100441781', 'display_name': 'Wei Zhang', 'orcid': 'https://orcid.org/0000-0003-3094-9711'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wei Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074762948', 'display_name': 'Yan Lin', 'orcid': 'https://orcid.org/0000-0002-4078-2612'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yan Lin', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018918849', 'display_name': 'Xiangzeng Liu', 'orcid': 'https://orcid.org/0000-0002-2751-6096'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xiangzeng Liu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056749211', 'display_name': 'Xun Jiang', 'orcid': 'https://orcid.org/0000-0002-3344-4797'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xun Jiang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100771165', 'display_name': 'Li Lan', 'orcid': 'https://orcid.org/0000-0003-0383-6172'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Li Lan', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 62}, 'biblio': {'volume': '34', 'issue': '7', 'first_page': '505', 'last_page': '509'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10066', 'display_name': 'Diversity and Function of Gut Microbiome', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10066', 'display_name': 'Diversity and Function of Gut Microbiome', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13569', 'display_name': 'Epidemiology and Treatment of Microscopic Colitis', 'score': 0.9577, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile Infection and Treatment', 'score': 0.9325, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dysbiosis', 'display_name': 'Dysbiosis', 'score': 0.8113897}, {'id': 'https://openalex.org/keywords/obesity-associated-microbiome', 'display_name': 'Obesity-associated Microbiome', 'score': 0.539621}, {'id': 'https://openalex.org/keywords/intestinal-mucosa', 'display_name': 'Intestinal mucosa', 'score': 0.5245514}, {'id': 'https://openalex.org/keywords/fecal-microbiota-transplantation', 'display_name': 'Fecal Microbiota Transplantation', 'score': 0.523741}, {'id': 'https://openalex.org/keywords/host-microbial-interactions', 'display_name': 'Host-Microbial Interactions', 'score': 0.508972}, {'id': 'https://openalex.org/keywords/intestinal-permeability', 'display_name': 'Intestinal permeability', 'score': 0.43396977}], 'concepts': [{'id': 'https://openalex.org/C2777165150', 'wikidata': 'https://www.wikidata.org/wiki/Q269334', 'display_name': 'Dysbiosis', 'level': 3, 'score': 0.8113897}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.6264822}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.56789565}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.55620587}, {'id': 'https://openalex.org/C3019368612', 'wikidata': 'https://www.wikidata.org/wiki/Q17154506', 'display_name': 'Intestinal mucosa', 'level': 2, 'score': 0.5245514}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.48643255}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45660734}, {'id': 'https://openalex.org/C539455810', 'wikidata': 'https://www.wikidata.org/wiki/Q739734', 'display_name': 'Gut flora', 'level': 2, 'score': 0.44300193}, {'id': 'https://openalex.org/C2781071285', 'wikidata': 'https://www.wikidata.org/wiki/Q17141320', 'display_name': 'Intestinal permeability', 'level': 2, 'score': 0.43396977}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.42929035}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.34283406}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.31849325}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25491613}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://rs.yiigle.com/CN101070201907/1130224.htm', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3198555927', 'https://openalex.org/W3174629814', 'https://openalex.org/W3152670291', 'https://openalex.org/W3113453804', 'https://openalex.org/W3089608153', 'https://openalex.org/W3080545417', 'https://openalex.org/W3039338741', 'https://openalex.org/W3032196560', 'https://openalex.org/W3029912875', 'https://openalex.org/W2995889425', 'https://openalex.org/W2981853284', 'https://openalex.org/W2980822417', 'https://openalex.org/W2953083275', 'https://openalex.org/W2401911612', 'https://openalex.org/W2381149738', 'https://openalex.org/W2376155348', 'https://openalex.org/W2356110991', 'https://openalex.org/W2350559575', 'https://openalex.org/W2140454850', 'https://openalex.org/W2042880181'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 38, 64, 91, 141, 148, 165, 179, 188, 213, 227], 'effect': [3], 'of': [4, 35, 53, 61, 80, 87, 93, 100, 104, 116, 140, 151, 197, 202, 215, 238, 251], 'antibiotic-induced': [5], 'microbiota': [6, 50], 'dysbiosis': [7], 'on': [8], 'colonic': [9, 94, 105], 'barrier': [10, 199, 249], 'and': [11, 25, 90, 113, 127, 147, 187, 205, 226, 247], 'immune': [12], 'response': [13, 260], 'in': [14, 119, 164, 178, 253], 'juvenile': [15, 254], 'mice.\r\n\r\n\r\nMethods\r\nTwenty': [16], 'Balb/c': [17], 'mice': [18, 52, 68, 203], 'were': [19, 31, 56, 69, 122, 131, 173, 190, 229], 'randomly': [20], 'divided': [21], 'into': [22], 'experimental': [23, 39, 142], 'group': [24, 40, 55, 143, 167, 181], 'control': [26, 54, 180], 'group.Broad': [27], 'spectrum': [28], 'antibiotic': [29, 166, 224], 'mixture': [30], 'administered': [32], 'by': [33, 85, 98, 124, 133], 'means': [34, 99], 'gavage': [36], 'to': [37, 47, 74, 236], 'every': [41], '12': [42], 'hours': [43], 'for': [44], '14': [45], 'days': [46], 'induce': [48, 75], 'intestinal': [49, 76, 81, 128, 137, 198, 248], 'dysbiosis.The': [51], 'given': [57], 'an': [58], 'equal': [59], 'amount': [60], 'physiological': [62], 'saline.On': [63], '15th': [65], 'day,': [66], 'all': [67, 174], 'intraperitoneally': [70], 'injected': [71], 'with': [72], 'lipopolysaccharide(LPS)': [73], 'inflammatory': [77, 117, 152], 'reaction.The': [78], 'structure': [79], 'flora': [82], 'was': [83, 96, 107, 144], 'analyzed': [84], 'way': [86], '16SrRNA': [88], 'sequencing,': [89], 'morphology': [92], 'mucosa': [95, 106], 'observed': [97, 108], 'HE': [101], 'staining.The': [102], 'infiltration': [103], 'through': [109], 'toluidine': [110], 'blue': [111], 'staining': [112], 'immunohistochemistry.The': [114], 'levels': [115, 150], 'cytokines': [118, 153], 'colon': [120, 252], 'tissue': [121], 'measured': [123, 132], 'real-time': [125], 'PCR': [126], 'permeability-related': [129], 'parameters': [130], 'enzyme-linked': [134], 'immunosorbent': [135], 'assay.\r\n\r\n\r\nResults\r\nThe': [136], 'microbial': [138], 'composition': [139], 'significantly': [145], 'changed,': [146], 'expression': [149], 'interleukin': [154], '(IL)-1β,': [155], 'IL-6,': [156], 'IL-8,': [157], 'IL-10,': [158], 'tumor': [159], 'necrosis': [160], 'factor': [161], '(TNF)-α': [162], 'mRNA': [163], '(0.765±0.062,': [168], '0.082±0.040,': [169], '0.442±0.059,': [170], '0.469±0.079,': [171], '0.736±0.063)': [172], 'lower': [175], 'than': [176], 'those': [177], '(1.738±0.243,': [182], '1.090±0.104,': [183], '1.151±0.136,': [184], '1.066±0.102,': [185], '1.539±0.218),': [186], 'differences': [189, 228], 'statistically': [191, 230], 'significant': [192, 231], '(all': [193, 232], 'P<0.05).': [194], 'The': [195], 'expressions': [196], 'related': [200], 'gene': [201], 'ZO-1': [204], 'Occludin': [206], 'decreased': [207], '(0.639±0.071': [208], 'vs.1.347±0.224,': [209], '0.770±0.067': [210], 'vs.1.487±0.148)': [211], 'but': [212], 'level': [214], 'fecal': [216], 'albumin': [217], 'increased': [218], '[(6.419±0.552)': [219], 'mg/L': [220], 'vs.(6.079±0.011)': [221], 'mg/L]': [222], 'after': [223], 'exposure,': [225], 'P<0.05).\r\n\r\n\r\nConclusions\r\nAnti-biotic': [233], 'exposure': [234], 'leads': [235], 'changes': [237], 'enteric': [239], 'microbiota,': [240], 'which': [241], 'adversely': [242], 'affects': [243], 'local': [244], 'mucosal': [245], 'immunity': [246], 'function': [250], 'mice.\r\n\r\n\r\nKey': [255], 'words:': [256], '\r\nIntestinal': [257], 'microbiota;\xa0Antibiotic;\xa0Intestinal': [258], 'barrier;\xa0Immune': [259]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3028659035', 'counts_by_year': [], 'updated_date': '2024-09-23T20:10:44.615507', 'created_date': '2020-06-05'}