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'Rickey': [78, 177], 'E.': [79, 178, 180], 'Carter,': [80], 'PhD': [81], 'and': [82, 190, 240, 272, 275, 328, 400, 447, 452, 477, 484, 520, 546, 602, 629, 645, 660, 792, 813, 852, 965, 977, 982, 1037, 1050, 1087, 1125, 1173, 1176, 1207, 1221, 1248, 1258, 1269, 1281, 1300, 1322, 1377, 1412, 1536, 1543, 1589, 1596, 1623, 1634, 1673, 1685, 1704, 1734, 1743, 1749, 1764, 1772, 1820, 1872, 1902, 1913, 1950, 1983, 2027, 2067, 2078, 2105, 2120, 2145, 2150, 2176, 2186, 2200, 2206, 2262, 2275, 2289, 2298, 2324, 2369], 'William': [83, 191], 'Mauermann,': [85], 'MD': [86], 'BorlaugBarry': [89], 'Borlaug': [91, 1236, 1268, 1337, 1373, 1408, 1457, 1590, 1624, 1705, 1951, 1984, 2001, 2023, 2059, 2106, 2146, 2177, 2201, 2296, 2325], 'Departments': [92, 135, 152], 'Cardiovascular': [94, 109, 121, 137, 154, 1266, 1758, 1924, 2088, 2187, 2214], 'Medicine': [95, 138, 155], '(B.A.B.,': [96, 139, 156], 'D.M.P.,': [97, 140, 157], 'S.J.A.),': [98, 141, 158], 'Mayo': [99, 113, 125, 142, 159, 172, 186, 199, 541, 2015], 'Clinic,': [100, 114, 126, 143, 160, 173, 187, 200], 'Rochester,': [101, 115, 127, 144, 161, 174, 188, 201], 'MN.': [102, 116, 128, 145, 162, 175, 189, 202], ',': [103, 117, 129, 146, 163, 176], 'SchaffHartzell': [106], 'Schaff': [108], 'Surgery': [110, 122], '(H.V.S.,': [111, 123], 'A.P.),': [112, 124], 'PochettinoAlberto': [119], 'Pochettino': [120], 'PedrottyDawn': [132], 'Pedrotty': [134, 1934], 'AsirvathamSamuel': [149], 'Asirvatham': [151, 1270, 1473, 1948], 'AbelMartin': [166], 'Abel': [168], 'Anesthesiology': [169, 196], '(M.D.A.,': [170, 197], 'W.J.M.),': [171, 198], 'CarterRickey': [179], 'Carter': [181, 1459], 'Health': [182], 'Sciences': [183, 1197], 'Research': [184], '(R.E.C.),': [185], 'MauermannWilliam': [193], 'Mauermann': [195], 'Originally': [203, 2360], 'published17': [204], 'Sep': [205], '2018https://doi.org/10.1161/CIRCULATIONAHA.118.036006Circulation.': [206], '2018;138:2295–2297Other': [207], 'version(s)': [208], 'this': [210, 219, 384, 931], 'articleYou': [211], 'are': [212, 244, 359, 991, 1058, 1271, 1324], 'viewing': [213], 'most': [215, 908], 'recent': [216], 'version': [217], 'article.': [220], 'Previous': [221, 1496], 'versions:': [222], 'September': [223], '17,': [224, 2362], '2018:': [225], 'Ahead': [226], 'Print': [228], 'Half': [229], 'patients': [231, 410, 532, 766, 814, 839, 856, 867, 874, 911, 1155, 2271], 'with': [232, 379, 394, 397, 411, 443, 465, 641, 656, 676, 720, 740, 752, 786, 804, 807, 815, 820, 829, 844, 863, 866, 875, 889, 912, 926, 960, 1034, 1048, 1062, 1064, 1083, 1105, 1148, 1156, 1160, 1171, 1353, 1387, 1418, 1485, 1629, 1692, 1778, 1838, 1916, 2032, 2073, 2272], 'heart': [233, 927, 1351, 1385, 1416, 1483, 1836, 2030, 2183, 2273, 2285], 'failure': [234, 1352, 1386, 1417, 1484, 1837, 2031, 2072, 2274], 'have': [235, 331], 'preserved': [236, 611, 1354, 1388, 1419, 1486, 1839, 2033, 2074, 2276], 'ejection': [237, 1355, 1389, 1420, 1487, 1840, 2034, 2075, 2277], 'fraction': [238, 613, 2076], '(HFpEF),': [239], 'few': [241], 'effective': [242, 344], 'treatments': [243], 'available.1': [245], 'Elevation': [246], 'left': [248, 278, 623, 1012], 'ventricular': [249, 279, 1013], '(LV)': [250], 'filling': [251, 289, 300, 392, 507, 951, 1001, 1014], 'pressures': [252, 290, 393, 952, 1015, 1598], 'plays': [253], 'a': [254, 293, 367, 694, 721, 799, 1074, 1140, 1274, 1284, 1357, 1478, 1682, 1963], 'dominant': [255, 284], 'role': [256, 1379, 2282], 'pathophysiology': [259], 'HFpEF,': [261, 292], 'contributing': [262], 'symptoms': [264], 'dyspnea,': [266, 851, 1411], 'impaired': [267], 'exercise': [268, 1382, 2268], 'capacity,': [269], 'pulmonary': [270, 1024, 1413], 'hypertension,': [271], 'increased': [273, 663, 1147], 'morbidity': [274], 'mortality.1–3': [276], 'Although': [277, 835], 'diastolic': [280, 346, 372, 616], 'dysfunction': [281, 617], 'is': [282, 302, 312, 907, 920, 971, 1214, 1237], 'cause': [285], 'elevated': [287, 634, 650, 999], 'LV': [288, 345, 371, 391, 506, 607, 950, 1000], 'substantial': [294], 'component': [295], 'increase': [298, 457, 670, 699, 737, 801, 948, 1080, 1096], 'pressure': [301, 323, 508, 512, 1027, 1158], 'not': [303, 726, 868, 1223, 1304], 'related': [304], 'alterations': [306], 'viscoelastic': [308], 'muscle': [309, 350], 'properties': [310, 351], 'but': [311, 615, 696, 730], 'rather': [313], 'mediated': [314], 'by': [315, 325, 462, 530, 539, 679, 709, 745, 998, 1190, 1240], 'external': [316, 356], 'restraining': [317], 'effects': [318, 358, 990], 'attributable': [319], 'contact': [322], 'exerted': [324], 'pericardium': [327, 342, 398, 405, 448, 473, 494, 646, 716, 735, 753, 808, 821, 830, 1035, 1038, 1106, 1110, 1137, 1149, 1161, 1443], 'right': [329, 1828, 2284], 'heart.4,5We': [330], 'recently': [332], 'shown': [333, 1059], 'animal': [335], 'preparations': [336], 'that': [337, 366, 901, 939, 953], 'surgical': [338, 380, 407], 'resection': [339], 'improves': [343], 'compliance,': [347], 'even': [348], 'as': [349, 490, 917, 922, 1004, 1139, 1326, 1681], 'remain': [352], 'unchanged,': [353], 'because': [354], 'these': [355, 855, 870, 876, 986], 'constraining': [357], 'eliminated.5': [360], 'This': [361], 'led': [362], 'us': [363], 'hypothesize': [365], 'similar': [368, 789], 'benefit': [369], 'on': [370, 1011], 'reserve': [373, 1414], 'might': [374], 'be': [375, 924, 1305], 'attainable': [376], 'humans': [378, 959], 'pericardiotomy.': [381], 'To': [382], 'test': [383, 1077], 'hypothesis,': [385], 'we': [386, 937], 'compared': [387, 675, 702, 751], 'change': [389, 504], 'volume': [395, 488, 517, 625, 741, 805, 890, 956, 1017, 1031, 1046, 1084, 1102, 1169, 1446], 'loading': [396, 518, 655, 742, 806, 891, 957, 1032, 1047, 1085, 1103, 1170], 'intact': [399, 449, 647, 822, 1036, 1107, 1442], 'again': [401, 481], 'after': [402, 455, 521, 731, 1088, 1126, 1134], 'opening': [403, 522, 732, 1089, 1127, 1135], 'access': [408], 'risk': [412, 573, 961], 'factors': [413, 574, 962], 'HFpEF': [415, 845, 879, 964, 1754, 1885], 'who': [416], 'were': [417, 433, 437, 479, 568, 633, 760, 1122], 'referred': [418], 'cardiac': [420, 431, 459, 915], 'surgery': [421, 432], 'aortic': [423, 556], 'valve': [424, 557], 'or': [425, 466, 565, 1317], 'coronary': [426, 560, 594], 'artery': [427, 561], 'disease.Subjects': [428], 'undergoing': [429, 555], 'clinically-indicated': [430], 'prospectively': [434], 'enrolled.': [435, 569], 'Hemodynamics': [436], 'measured': [438, 480], 'invasively': [439], 'under': [440, 638], 'general': [441, 639], 'anesthesia': [442, 640], 'sternum': [445, 643], 'open': [446, 644, 809, 831, 1039, 1111, 1177], 'at': [450, 482, 1331], 'baseline': [451, 483, 677, 704, 728], 'then': [453, 475, 718], 'immediately': [454], 'acute': [456, 976, 988, 1445], 'preload,': [460], 'achieved': [461], 'leg': [463, 658, 768, 1051, 1065, 1174, 1182], 'elevation': [464, 1066], 'without': [467, 772, 941], '250': [468], 'mL': [469], 'saline': [470, 661, 774, 1049, 1172], 'bolus.': [471], 'The': [472, 497, 535, 1212, 1289, 1296, 2014, 2281, 2302], 'was': [474, 495, 502, 528, 537, 549, 579, 586, 590, 610, 618, 648, 717, 743, 770, 788, 1188], 'opened,': [476], 'hemodynamics': [478], 'following': [485], 'same': [487], 'load': [489], 'performed': [491, 771], 'when': [492], 'intact.': [496, 1162], 'prespecified': [498], 'primary': [499], 'end': [500, 1054], 'point': [501], '(pulmonary': [509], 'capillary': [510, 1025], 'wedge': [511, 1026], '[PCWP])': [513], 'response': [515, 1029, 1100], 'before': [519, 533, 846, 1086, 1124], 'pericardium.': [524, 1091, 1129], 'Written': [525], 'informed': [526], 'consent': [527], 'obtained': [529], 'all': [531, 1041, 1251], 'evaluation.': [534], 'study': [536, 970, 1301], 'approved': [538], 'Clinic': [542, 2016], 'Institutional': [543], 'Review': [544, 1638], 'Board': [545], 'trial': [548], 'registered': [550], '(NCT03073668).Nineteen': [551], 'subjects': [552, 796, 1166, 1180], '(32%': [553], 'women)': [554], 'replacement': [558], '(42%),': [559], 'bypass': [562], 'grafting': [563], '(26%),': [564], 'both': [566], '(32%)': [567], 'Subjects': [570], 'displayed': [571, 798, 857], 'multiple': [572], 'HFpEF:': [576], 'mean': [577, 582], 'age': [578], '71±10': [580], 'years,': [581], 'body': [583], 'mass': [584], 'index': [585, 626], '32.5±5.3': [587], 'kg/m2;': [588], 'hypertension': [589], 'present': [591], '79%,': [593], 'disease': [595], '74%,': [597], 'atrial': [598, 624], 'fibrillation': [599], '21%,': [601], 'diabetes': [603], 'mellitus': [604], '47%.': [606], 'systolic': [608], 'function': [609, 1141], '(ejection': [612], '59±10%)': [614], 'highly': [619], 'prevalent': [620], "(E/e'": [621], '14±5,': [622], '36±13': [627], 'mL/m2)': [628], 'plasma': [630], 'NT-proBNP': [631, 861], 'levels': [632], '(594±333': [635], 'pg/mL).Baseline': [636], 'PCWP': [637, 664, 701, 739, 785, 803, 819, 828, 888, 1082, 1098, 1146], 'mildly': [649], '(16±5': [651], 'mm': [652, 667, 673, 706, 748, 895], 'Hg).': [653], 'combined': [657, 773, 1045, 1168], 'raise': [659, 687, 769, 1052, 1183], 'infusion': [662, 775], '25±5': [666], 'Hg,': [668, 707, 749, 896], 'an': [669, 1327], '+9±3': [672], 'Hg': [674], '(P<0.0001': [678], 'paired': [680, 710, 1075], 't': [681, 711, 1076], 'test;': [682, 712], 'Figure,': [683, 713, 755, 777], 'panel': [684, 714, 756, 778, 811, 833], 'A).': [685, 757], 'Leg': [686], 'alone': [688, 1067], '(without': [689], 'concomitant': [690], 'saline,': [691], 'n=5)': [692], 'produced': [693], 'lesser': [695, 800], 'still': [697], 'significant': [698], '(+5±1': [705], 'P=0.002': [708], 'B)The': [715], 'opened': [719], 'longitudinal': [722], 'incision.': [723], 'Pericardiotomy': [724, 1961], 'did': [725], 'reduce': [727], 'PCWP,': [729], 'reduced': [744], '67%': [746], '(+3±3': [747], 'P<0.0001': [750], 'intact;': [754], 'Similar': [758, 1568], 'findings': [759], 'observed': [761], 'subgroup': [764], 'where': [767], '(P=0.018;': [776], 'B).': [779, 1070], 'Mitigation': [780], 'rise': [783, 886], 'pericardiotomy': [787, 906, 1010], 'men': [791], 'women': [793], '(not': [794], 'shown).Most': [795], '(95%)': [797], '(Figure,': [810, 832], 'C),': [812], 'greater': [816, 824, 1152, 1157, 1829], 'increases': [817, 1159], 'experienced': [823, 880], 'absolute': [825], 'reductions': [826], 'D).': [834], 'none': [836], 'had': [840], 'been': [841], 'clinically': [842], 'diagnosed': [843], 'surgery,': [847], '13': [848], '(68%)': [849], 'reported': [850], '10': [853, 873], 'abnormal': [858], "E/e'": [859], 'and/or': [860], 'consistent': [862], 'HFpEF.': [864], 'Compared': [865], 'meeting': [869], 'criteria,': [871], 'features': [877], 'more': [881], 'favorable': [882], 'mitigation': [883], '(−7±2': [892], 'versus': [893], '−3±2': [894], 'P=0.003).': [897], 'These': [898], 'results': [899, 1316], 'suggest': [900], 'unloading': [903], 'effect': [904, 1440], 'pronounced': [909], 'greatest': [914], 'distention': [916], 'venous': [918], 'return': [919], 'increased,': [921], 'would': [923], 'expected': [925], 'failure.In': [928], 'summary,': [929], 'first': [932], 'man': [934], 'pilot': [935], 'study,': [936], 'demonstrate': [938], 'pericardiotomy,': [940, 981], 'extensive': [942], 'pericardial': [943, 967, 1286, 1476], 'resection,': [944], 'substantially': [945], 'attenuates': [946], 'develops': [954], 'during': [955, 1016, 1444], 'no': [966, 1293], 'disease.': [968], 'Further': [969], 'warranted': [972], 'evaluate': [974], 'long-term': [978], 'safety': [979], 'determine': [984], 'whether': [985], 'beneficial': [987], 'hemodynamic': [989], 'sustained': [992], 'chronically': [993], 'patient': [995], 'populations': [996], 'afflicted': [997], 'pressures,': [1002], 'such': [1003], 'HFpEF.Download': [1005], 'figureDownload': [1006], 'PowerPointFigure.': [1007], 'Effects': [1008], 'loading.': [1018], 'Line': [1019], 'graphs': [1020], 'plot': [1021], 'changes': [1022, 1063], '(ΔPCWP)': [1033, 1104], 'patients.': [1042], 'Responses': [1043], '(primary': [1053], 'point,': [1055], 'solid': [1056], 'circles)': [1057], '(A)': [1060], 'along': [1061], '(open': [1068], 'circles;': [1069], 'P': [1071, 1588, 1822], 'values': [1072], 'reflect': [1073], 'comparing': [1078], 'C,': [1092, 1933, 2062], 'Scatterplot': [1093], '(abscissa)': [1108], 'vs': [1109], '(ordinate).': [1112], 'Dashed': [1113], 'line': [1114, 1117], 'indicates': [1115], 'unity': [1119], 'if': [1120], 'responses': [1121], 'equal': [1123], 'D,': [1130, 1799, 1858, 1868, 1935, 1943], 'Change': [1131], 'ΔPCWP': [1133], 'plotted': [1138], 'how': [1143], 'much': [1144], 'intact,': [1150], 'showing': [1151], 'reduction': [1153], 'Solid': [1163], 'circles': [1164, 1178], 'indicate': [1165, 1179], 'receiving': [1167, 1181], 'raise,': [1175], 'alone.Sources': [1184], 'FundingThis': [1186], 'research': [1187], 'supported': [1189, 1239], 'National': [1192, 1200, 1231, 1254], 'Center': [1193], 'Advancing': [1195], 'Translational': [1196, 1891], 'Institutes': [1201, 1232, 1255], 'Health,': [1203, 1257], 'award': [1204], 'numbers': 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