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'Tardy': [185], 'initiation': [186], 'preventive': [188], 'strategies': [189], 'likely': [190, 234], 'contributes': [191, 825], 'risk.': [195, 510, 778], 'For': [196], 'example,': [197], 'evidence': [199, 273, 713], 'shows': [200, 563], 'that': [201, 240, 252, 274, 344, 401, 477, 506, 532, 629, 636, 715, 792, 812, 971, 1033, 1095, 1152, 1159, 1210], 'lifetime': [202], 'exposure': [203], 'such': [207, 415, 462, 945, 992], 'as': [208, 463, 819, 993, 1300, 1776, 2657], 'high': [209], 'lipoprotein': [211], 'attributable': [212, 784, 952, 1175], 'genetic': [214, 1019, 1815], 'variants': [215], 'confers': [216], 'cumulative': [218], 'greater': [220], 'than': [221, 266], 'acquired': [222, 360], 'hypercholesterolemia.': [223], 'In': [224, 548, 959], 'addition,': [225], 'beyond': [228], 'classic': [230], 'covariates': [232], 'very': [233], 'contribute': [235], 'risk.The': [238], 'recognition': [239, 1072], 'inflammation': [241, 277, 1656, 1749, 1958], 'can': [242, 522, 888, 936], 'drive': [243, 637], 'complications': [245, 1105], 'led': [246, 352], 'Atillio': [247], 'Maseri': [248, 1277], 'opine': [250], 'presciently': [251], 'insight': [254, 1099], 'provided': [255], 'glimpse': [257], '“hidden': [260], 'side': [261, 1286], 'moon.”1': [264], 'More': [265], '2': [267], 'decades': [268], 'later,': [269], 'now': [271, 1138], 'intervening': [275], 'on': [276, 403, 558, 848, 1129, 1942, 2380, 2760], 'addition': [279], 'guideline-directed': [281], 'provides': [288, 1111, 1182], 'one': [289, 975], 'additional': [290], 'avenue': [291], 'reducing': [293], 'risk.2If': [296], 'deepen': [298], 'exploration': [300], 'obscure': [303], 'lunar': [304], 'landscape': [305], 'evoked': [308], 'Maseri,': [310], 'could': [311], 'uncover': [313], 'even': [314, 688, 763, 790], 'other': [315, 1107], 'heretofore': [316], 'unsuspected': [317, 906], 'contributors': [318], 'risk?': [322, 910], 'Recent': [323], 'findings': [324, 1884], 'suggest': [325], 'that,': [326], 'indeed,': [327], 'overlooked': [330], 'an': [331, 427, 699, 772, 1041, 1199, 2318], 'important': [332, 2319], 'driver': [333, 1020, 2488], 'disease.': [336, 728, 1119, 1191], 'A': [337, 1545, 1695, 1770, 1777, 1901, 2078, 2108, 2111, 2281, 2291, 2456, 2516, 2746, 2789, 2875, 3013], 'quest': [338], 'understanding': [340, 1084, 1217], 'fundamental': [342, 897], 'defects': [343], 'predispose': [345], 'development': [348], 'hematologic': [350, 431, 578, 696], 'malignancies': [351], 'realization.As': [355], 'age,': [357], 'accumulate': [359, 518], 'mutations': [361, 512, 603, 807], 'hematopoietic': [363], 'stem': [364, 386, 516], 'cells': [365, 387, 495, 517], 'bone': [368, 514], 'marrow,': [369], 'some': [370, 794], 'which': [372, 1015], 'confer': [373], 'competitive': [375], 'advantage': [376], '(Figure).': [377], 'As': [378], 'consequence,': [380], 'clonal': [381, 444, 527, 668, 1389, 1821, 2477, 2711], 'progeny': [382], 'mutant': [385, 475, 494, 530, 568, 755], 'appear': [388, 613], 'peripheral': [390, 409, 482, 535, 549, 849], 'blood.': [391], 'By': [392, 1534], 'age': [393, 520], '70,': [394], '>10%': [395], 'individuals': [397, 571, 689], 'harbor': [398], 'these': [399, 424, 754], 'clones': [400, 416, 425, 476, 546], 'account': [402, 552, 604, 900, 916], 'average': [404, 560], '≈20%': [406, 555], 'their': [408, 481], 'white': [410], 'cells.3': [411], 'The': [412, 442, 467, 779, 1071, 1120, 1150, 1814, 1903, 2089, 2580, 2748], 'presence': [413], 'represents': [417], 'premalignant': [419], 'state,': [420], 'carriers': [422, 455, 582, 737], 'elevated': [428, 982], 'incidence': [429, 1171], 'malignancies,': [432], 'with': [433, 474, 497, 519, 572, 648, 690, 722, 751, 761, 768, 809, 843, 874, 1028, 1057, 1155, 1392, 1820, 2234, 2452, 2528, 2532, 3003], 'rate': [435], 'progression': [437], '≈0.5%': [439], 'per': [440], 'year.': [441], 'term': [443], 'hematopoiesis': [445, 503, 669, 1390, 1448, 2478, 2712], 'indeterminate': [447, 671, 2714], 'potential': [448, 2715], '(CHIP)': [449], 'describes': [450], 'condition,': [452], 'because': [453, 619, 862], 'most': [454, 606], 'will': [456, 574], 'never': [457, 575, 693], 'develop': [458, 576, 662, 694], 'full-blown': [460], 'malignancy,': [461, 579], 'acute': [464, 1068, 2159], 'myeloid': [465, 2053, 2160], 'leukemia.': [466], 'diagnosis': [468], 'CHIP': [470, 573, 581, 641, 666, 691, 723, 736, 786, 810, 831, 845, 954, 979, 1008, 1078], 'applies': [471], 'those': [473, 752, 764, 1247], 'exceed': [478, 791], '2%': [479], 'leukocyte': [483], 'count.': [484], 'It': [485, 2374], 'is': [486, 852, 1016], 'not': [487, 816, 853, 1163, 1212, 1245], 'clear': [488], 'yet': [489], 'whether': [490, 886, 944], 'correlates': [496], 'risk.Download': [499], 'figureDownload': [500], 'PowerPointFigure.': [501], 'Clonal': [502, 1447, 1841, 2259, 2286, 2344, 2847, 3018], 'mechanisms': [505, 898, 946], 'might': [507, 899], 'accelerate': [508], 'atherothrombotic': [509], 'Acquired': [511], 'marrow': [515], 'give': [523], 'rise': [524], 'population': [528], 'leukocytes': [531, 557], 'circulate': [533], 'blood,': [536, 550, 850], 'condition': [538, 770, 814, 1025], 'called': [539], 'CHIP.': [540, 609, 875, 922], 'This': [541], 'figure': [542], 'depicts': [543], 'how': [544, 868], 'arise.': [547], 'they': [551], '(this': [561], 'diagram': [562], 'only': [564, 913, 1164, 1194, 1213], 'minority': [566], 'cells).': [569], 'Most': [570], 'but': [580, 824, 1136, 1168, 1221], 'marked': [585, 702], 'increase': [586, 630, 703, 775, 839, 907], 'myocardial': [591], 'infarction,': [592], 'stroke,': [593], 'perhaps': [595], 'venous': [596], 'thrombosis': [597, 1066, 1517], 'pulmonary': [599], 'embolism.': [600], 'Only': [601], '4': [602, 914], 'cases': [607, 920], 'Some': [610], 'them': [612], 'cause': [615], 'increased': [616, 649, 949], 'changes': [621, 935], 'methylation': [624], 'DNA,': [626], 'epigenetic': [627, 934], 'alterations': [628], 'transcription': [632], 'proinflammatory': [634, 988], 'genes': [635, 915, 926], 'atherogenesis.': [638], 'Another': [639, 1006], 'common': [640, 978, 1007], 'mutation': [642, 1009, 1038, 2199], 'kinase': [645, 2049], 'Jak2': [646, 1037], 'associates': [647, 759], 'thrombotic': [650, 1030], 'attributable,': [652], 'at': [653, 957, 1195], 'least': [654], 'part,': [656], 'heightened': [659], 'propensity': [660], 'neutrophil': [663, 1046, 1512], 'extracellular': [664, 1047, 1513], 'traps.': [665], 'indicates': [667], 'potential;': [672], 'CXCL,': [673], 'CXC': [674], 'chemokine': [675], 'ligand;': [676], 'IL-1β,': [677], 'interleukin': [678, 681, 1161], '1β;': [679], 'IL-6,': [680], '6;': [682], 'Pf4,': [684], 'platelet': [685], 'factor': [686], '4.But': [687], 'who': [692], 'malignancy': [697], 'unexpected': [700, 1184], 'mortality.': [705], 'Surprisingly,': [706], 'number': [708], 'independent': [710], 'lines': [711], 'established': [714], 'gap': [717], 'mortality': [719, 1174], 'people': [721], 'results': [724], 'excess': [726], 'Fully': [729], 'adjusted': [730], 'all': [732, 919], 'factors,': [735, 1062], 'almost': [739, 773, 918], 'doubling': [741], 'relative': [744], 'disease': [748, 1219, 1630], 'comparison': [750], 'without': [753, 3005], 'clones.3,4': [756], 'Although': [757], 'aging': [758, 1707], 'strongly': [760, 999], 'CHIP,': [762], '<50': [765], 'years': [766], 'old': [767], '4-fold': [774], 'magnitude': [780], 'enrichment': [783], 'rivals': [787], 'or': [788, 930, 1251, 3004], 'may': [789, 832], 'variables.': [796], 'Studies': [797], 'experimental': [799, 1963], 'mice': [802, 970], 'engineered': [803], 'bear': [805, 972], 'associated': [808, 873, 1027, 1391, 2531], 'indicate': [811], 'does': [815], 'merely': [817], 'serve': [818], 'marker': [821], 'aging,': [823, 1908], 'causally': [826], 'accelerated': [828], 'atherosclerosis.4': [829], 'Indeed,': [830, 876], 'help': [833], 'explain': [835], 'mechanistically': [836], 'steep': [838], 'aging.Diagnosing': [844], 'requires': [846, 2162], 'sequencing': [847, 1889, 2586], 'currently': [854], 'practical': [856], 'routine': [857], 'clinical': [858], 'test,': [859], 'particular,': [861], 'no': [865], 'information': [866], 'about': [867], 'mitigate': [870], 'key': [878, 2322], 'goal': [879], 'future': [881], 'research': [882], 'would': [883], 'be': [884], 'testing': [885], 'interventions': [887, 2556], 'limit': [889], 'previously': [891], 'unrecognized': [892], 'contributor': [893], 'risk.What': [896], 'striking': [903], 'hitherto': [905], 'Mutations': [911], 'Three': [923], 'alter': [927], 'either': [928], 'DNA': [929, 1051], 'histone': [931], 'methylation.': [932], 'Such': [933], 'influence': [937], 'level': [939], 'gene': [941], 'expression,': [942], 'although': [943], 'mediate': [947], 'remains': [955], 'speculative': [956], 'present.': [958], 'support': [960], 'dysregulated': [962], 'expression': [963, 983], 'inflammatory': [965], 'genes,': [966, 989], 'macrophages': [968], 'Tet2': [973], 'mutations,': [974, 980, 2489], 'set': [986], 'cytokines': [991], 'interleukins': [994], '6': [995], '1,': [997], 'mediators': [998], 'implicated': [1000, 1064], 'promoting': [1002], 'human': [1003, 2158], 'events.': [1005], 'occurs': [1010], 'kinase,': [1013], 'Jak2,': [1014], 'dominant': [1018], 'polycythemia': [1022], 'vera,': [1023], 'long': [1026], 'diathesis.': [1031], 'Neutrophils': [1032], 'carry': [1034], 'specific': [1036], '(V617F)': [1039], 'exhibit': [1040], 'enhanced': [1042], 'ability': [1043], 'form': [1045], 'traps,': [1048], 'strands': [1049], 'released': [1052], 'dying': [1054], 'granulocytes': [1055], 'studded': [1056], 'pro-oxidant,': [1058], 'proteolytic,': [1059], 'prothrombotic': [1061], 'recently': [1063], 'events.5': [1070], 'strong': [1075], 'link': [1076, 1113, 1185], 'between': [1077, 1114, 1186, 1205], 'events': [1081, 3000], 'expands': [1082], 'opens': [1089], 'up': [1090], 'new': [1091, 1225], 'avenues': [1092], 'investigation': [1094], 'promise': [1096], 'provide': [1098], 'pathophysiology': [1102], 'atherosclerotic': [1104, 1452, 2938], 'conditions.CHIP': [1109], 'also': [1110, 1169, 1222], 'another': [1112, 1183], 'cancer': [1115, 1178, 1187, 1886, 2087, 2558, 3006], 'biology': [1116, 1188], 'burgeoning': [1121], 'field': [1122], 'cardio-oncology': [1124], 'has': [1125, 1235], 'focused': [1126], 'so': [1127], 'far': [1128], 'adverse': [1131, 1393], 'effects': [1132], 'anticancer': [1134], 'therapies,': [1135], 'should': [1137], 'broaden': [1139], 'its': [1140], 'scope': [1141], 'include': [1143], 'shared': [1144], 'pathophysiologic': [1148], 'mechanisms.': [1149], 'finding': [1151], 'anti-inflammatory': [1153], 'therapy': [1154], 'monoclonal': [1157], 'antibody': [1158], 'neutralizes': [1160], '1': [1162], 'reduces': [1165], 'events,': [1167], 'lung': [1177], 'exploratory': [1180], 'analyses,': [1181], 'We': [1192], 'are': [1193, 1244], 'beginning': [1197], 'exciting': [1200], 'era': [1201], 'convergence': [1204], 'oncology': [1206], 'medicine': [1209], 'promises': [1211], 'improve': [1215], 'mechanisms,': [1220], 'identify': [1224], 'approaches': [1226], 'stratification': [1229], 'targets': [1231], 'therapy.DisclosuresDr': [1233], 'consulted': [1236], 'Celgene.Footnoteshttps://www.ahajournals.org/journal/circThe': [1238], 'opinions': [1239], 'expressed': [1240], 'article': [1243], 'necessarily': [1246], 'editors': [1250], 'American': [1254, 1637, 2022, 2418, 2852, 3080], 'Association.Peter': [1256], 'protected]harvard.eduReferences1.': [1276], 'A.': [1278], 'Inflammation,': [1279, 2633], 'atherosclerosis,': [1280, 2326, 2636], 'ischemic': [1282], 'events—exploring': [1283], 'hidden': [1285], 'moon.N': [1289], 'Engl': [1290, 1395, 1455], 'J': [1291, 1396, 1456, 1543, 1930, 2229, 2366, 2401, 3059], 'Med.': [1292, 1397, 1457, 1522], '1997;': [1293], '336:1014–1016.CrossrefMedlineGoogle': [1294], 'Scholar2.': [1295], 'P.': [1297], 'Interleukin-1': [1298], 'beta': [1299], 'target': [1302, 2324, 2754], 'therapy:': [1305], 'biological': [1306], 'basis': [1307], 'CANTOS': [1309], 'beyond.J': [1311], 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1418, 1858, 1992, 2033, 2106, 2130, 2864, 2948, 2968], 'Chavez': [1338], 'Higgins': [1340], 'JM,': [1341], 'Moltchanov': [1342], 'V,': [1343, 1428, 2393, 3054], 'Kuo': [1344], 'FC,': [1345], 'Kluk': [1346], 'MJ,': [1347], 'Henderson': [1348], 'B,': [1349, 1500, 1874, 2148, 2397, 2892], 'Kinnunen': [1350], 'L,': [1351, 1377, 1571, 1691, 1727, 1795, 2606, 2739, 2777, 2826], 'Koistinen': [1352], 'HA,': [1353], 'Ladenvall': [1354], 'C,': [1355, 1375, 1502, 1573, 1729, 2035, 2132, 2180, 2785, 2834], 'Getz': [1356], 'G,': [1357, 1379, 1496, 1538, 1733, 2277, 2279, 2608, 2727, 2773], 'Correa': [1358], 'Banahan': [1360], 'BF,': [1361], 'Gabriel': [1362, 1419], 'Kathiresan': [1364, 1443], 'Stringham': [1366], 'HM,': [1367], 'McCarthy': [1368], 'MI,': [1369], 'Boehnke': [1370], 'M,': [1371, 1416, 1472, 1488, 1737, 1768, 1982, 1986, 1996, 2070, 2138, 2142, 2176, 2503, 2506, 2508, 2612, 2699, 2771, 2781, 2868, 2896, 2960, 2984], 'Tuomilehto': [1372], 'Haiman': [1374], 'Groop': [1376], 'Atzmon': [1378], 'Wilson': [1380], 'JG,': [1381], 'Neuberg': [1382, 1439, 1503], 'D,': [1383, 1385, 1422, 1434, 1440, 1470, 1478, 1504, 1693, 2031, 2037, 2128, 2824, 2840, 2946], 'Altshuler': [1384], 'BL.': [1387, 1446, 1510], 'Age-related': [1388, 1746], 'outcomes.N': [1394], '2014;': [1398], '371:2488–2498.': [1399], '10.1056/NEJMoa1408617CrossrefMedlineGoogle': [1401], 'Scholar4.': [1402], 'Natarajan': [1405], 'Silver': [1407, 1475, 3012], 'AJ,': [1408, 1476], 'Gibson': [1409], 'CJ,': [1410], 'Bick': [1411], 'AG,': [1412], 'Shvartz': [1413], 'E,': [1414, 1536, 1766, 2126, 2395, 2436, 2703, 2735, 2775, 2972], 'McConkey': [1415, 1471], 'Gupta': [1417, 2823], 'Ardissino': [1421], 'Baber': [1423], 'U,': [1424], 'Mehran': [1425], 'R,': [1426, 1671, 1731, 1739, 2190, 2741, 2820, 2836, 2866, 3031], 'Fuster': [1427], 'Danesh': [1429], 'Frossard': [1431], 'Saleheen': [1433], 'Melander': [1435], 'O,': [1436, 1464, 2701], 'Sukhova': [1437], 'GK,': [1438], 'disease.N': [1454], '377:111–121.': [1459], '10.1056/NEJMoa1701719CrossrefMedlineGoogle': [1461], 'Scholar5.': [1462], 'Wolach': [1463], 'Sellar': [1465, 3032], 'RS,': [1466], 'Martinod': [1467], 'K,': [1468, 1807, 1860, 1864, 1866, 1868, 1984, 1994, 2074, 2186, 2838, 2954, 2956, 2976, 2986], 'Cherpokova': [1469], 'Chappell': [1473], 'RJ,': [1474], 'Adams': [1477], 'Castellano': [1479], 'CA,': [1480], 'Schneider': [1481], 'RK,': [1482], 'Padera': [1483], 'RF,': [1484], 'DeAngelo': [1485], 'DJ,': [1486], 'Wadleigh': [1487], 'Steensma': [1489, 2839], 'DP,': [1490], 'Galinsky': [1491], 'I,': [1492, 1928, 2511, 2693, 2779], 'Stone': [1493, 1738], 'RM,': [1494], 'Genovese': [1495], 'McCarroll': [1497], 'SA,': [1498], 'Iliadou': [1499], 'Hultman': [1501], 'Mullally': [1505], 'Wagner': [1507], 'DD,': [1508], 'Increased': [1511], 'trap': [1514], 'formation': [1515], 'promotes': [1516], 'myeloproliferative': [1519, 2211], 'neoplasms.Sci': [1520], 'Transl': [1521], '2018;': [1523], '10:eaan8292.': [1524], '10.1126/scitranslmed.aan8292CrossrefMedlineGoogle': [1526], 'Scholar': [1527], 'Previous': [1528], 'Back': [1529], 'top': [1531], 'Next': [1532], 'FiguresReferencesRelatedDetailsCited': [1533], 'Kowalski': [1535], 'Qian': [1537], 'Vanni': [1539], 'K': [1540, 1600, 1998, 2990, 2993], 'Sparks': [1542], '(2022)': [1544, 1579, 1601, 1628, 1654, 1699, 1745, 1774], 'Roadmap': [1546], 'Investigating': [1548], 'Preclinical': [1549, 2447], 'Autoimmunity': [1550], 'Using': [1551], 'Patient-Oriented': [1552], 'Epidemiologic': [1554], 'Designs:': [1556], 'Example': [1557], 'Rheumatoid': [1559], 'Arthritis,': [1560], 'Frontiers': [1561, 1586, 2886], 'Immunology,': [1563], '10.3389/fimmu.2022.890996,': [1564], '13': [1565], 'Puspitasari': [1566], 'Y,': [1567, 1797, 1799, 1926, 1980, 2102, 2178, 2952, 2962, 2980], 'Ministrini': [1568], 'Schwarz': [1570], 'Karch': [1572], 'Liberale': [1574], 'L': [1575, 1812, 2472, 2614], 'Camici': [1577], 'G': [1578, 2043], 'Modern': [1580], 'Concepts': [1581], 'Disease:': [1584], 'Inflamm-Aging,': [1585], 'Cell': [1588], 'Developmental': [1590], 'Biology,': [1591], '10.3389/fcell.2022.882211,': [1592], '10': [1593, 2890], 'Anzai': [1594], 'Ko': [1596], 'S': [1597, 1773, 2001, 2575, 2679, 2792, 3016], 'Fukuda': [1599], 'Immune': [1602], 'Inflammatory': [1604], 'Networks': [1605], 'Myocardial': [1607], 'Infarction:': [1608], 'Current': [1609, 1633, 2240, 2267], 'Research': [1610, 1642], 'Its': [1612], 'Potential': [1613, 2263], 'Implications': [1614], 'Clinic,': [1617], 'International': [1618, 1786], 'Journal': [1619, 1639, 1787, 2019, 2213, 2297, 2415, 2459, 2591, 2849], 'Molecular': [1621, 1789, 1827], 'Sciences,': [1622, 1790], '10.3390/ijms23095214,': [1623], '23:9,': [1624], '(5214)': [1625], 'Akhter': [1626], 'N': [1627, 2513], 'Vascular': [1629, 1784, 2796], 'cancer:': [1632], 'emerging': [1635], 'concepts,': [1636], 'Plus:': [1640], 'Cardiology': [1641, 2241], 'Practice,': [1644], '10.1016/j.ahjo.2022.100143,': [1645], '17,': [1646], '(100143),': [1647], 'Online': [1648, 1662, 1722, 1761, 1831, 1853, 1896, 1917, 1975, 2026, 2063, 2171, 2221, 2245, 2272, 2333, 2358, 2388, 2425, 2495, 2540, 2568, 2597, 2626, 2644, 2671, 2766, 2813, 2859, 2926, 3050, 3065], 'publication': [1649, 1663, 1723, 1762, 1832, 1854, 1897, 1918, 1976, 2027, 2064, 2172, 2222, 2246, 2273, 2334, 2359, 2389, 2426, 2496, 2541, 2569, 2598, 2627, 2645, 2672, 2767, 2814, 2860, 2927, 3051, 3066], 'date:': [1650, 1664, 1724, 1763, 1833, 1855, 1898, 1919, 1977, 2028, 2065, 2173, 2223, 2247, 2274, 2335, 2360, 2390, 2427, 2497, 2542, 2570, 2599, 2628, 2646, 2673, 2768, 2815, 2861, 2928, 3052, 3067], '1-May-2022.': [1651], 'Nathan': [1652], 'C': [1653, 1809, 2155, 2654], 'Nonresolving': [1655], 'redux,': [1657], 'Immunity,': [1658], '10.1016/j.immuni.2022.03.016,': [1659], '55:4,': [1660], '(592-605),': [1661], '1-Apr-2022.': [1665, 1725], 'Kiss': [1666], 'T,': [1667, 1675, 1988, 1990, 2573, 2902, 2958, 2964, 2970, 2982], 'Nyúl-Tóth': [1668], 'Á,': [1669], 'Gulej': [1670], 'Tarantini': [1672], 'Csipo': [1674], 'Mukli': [1676], 'Ungvari': [1678, 1697], 'Balasubramanian': [1680], 'Yabluchanskiy': [1682], 'Benyo': [1684], 'Z,': [1685, 1805], 'Conley': [1686], 'Wren': [1688], 'Garman': [1690], 'Huffman': [1692], 'Csiszar': [1694], 'Z': [1698], 'Old': [1700], 'blood': [1701], 'heterochronic': [1703], 'parabionts': [1704], 'accelerates': [1705], 'vascular': [1706], 'young': [1709], 'mice:': [1710], 'transcriptomic': [1711], 'signature': [1712], 'pathologic': [1714], 'smooth': [1715], 'muscle': [1716], 'remodeling,': [1717], 'GeroScience,': [1718], '10.1007/s11357-022-00519-1,': [1719], '44:2,': [1720], '(953-981),': [1721], 'Weeks': [1726], 'Marinac': [1728], 'Redd': [1730], 'Abel': [1732], 'Lin': [1734, 1877, 2189, 2650, 2821], 'Agrawal': [1736], 'Schrag': [1740], 'D': [1741, 2314, 2338, 2934], 'B': [1744, 2081, 2404, 2845, 3036], 'diseases': [1747], 'myelodysplastic': [1751, 2588], 'syndrome': [1752], 'chronic': [1754, 2052], 'myelomonocytic': [1755], 'leukemia,': [1756], 'Blood,': [1757, 2167], '10.1182/blood.2021014418,': [1758], '139:8,': [1759], '(1246-1250),': [1760], '24-Feb-2022.': [1764], 'Barbu': [1765], 'Popescu': [1767, 1769], 'Balanescu': [1772], 'Inflammation': [1775, 2794, 2936], 'Precursor': [1778], 'Atherothrombosis,': [1780], 'Diabetes': [1781], 'Early': [1783], 'Aging,': [1785], '10.3390/ijms23020963,': [1791], '23:2,': [1792], '(963)': [1793], 'Zhang': [1794, 2067], 'Shi': [1796, 1802], 'Chen': [1798, 1806, 2183], 'Tao': [1800], 'W,': [1803, 2188], 'He': [1804], 'Wang': [1808, 2653], 'Yu': [1811], '(2021)': [1813, 1840, 1882, 1902, 1934, 1956, 2002, 2047, 2082, 2112], 'analysis': [1816], 'Chinese': [1818], 'patients': [1819, 2527, 3002], 'cytopenias': [1822], 'using': [1823], 'targeted': [1824], 'next-generation': [1825], 'sequencing,': [1826], 'Cytogenetics,': [1828], '10.1186/s13039-021-00572-z,': [1829], '14:1,': [1830], '1-Dec-2021.': [1834, 1856, 1899, 1920], 'Köhnke': [1835], 'T': [1836, 2226, 2311, 2872], 'Majeti': [1838], 'R': [1839, 1881, 2842, 2906, 3033], 'Hematopoiesis:': [1842], 'From': [1843, 2480, 2798], 'Mechanisms': [1844, 1909], 'Clinical': [1846, 2449, 2461], 'Intervention,': [1847], 'Discovery,': [1849, 1971], '10.1158/2159-8290.CD-21-0901,': [1850], '11:12,': [1851], '(2987-2997),': [1852], 'Maani': [1857], 'Panabaker': [1859], 'McCuaig': [1861], 'Buckley': [1863], 'Semotiuk': [1865], 'Farncombe': [1867], 'Ainsworth': [1869], 'Panchal': [1871], 'Sadikovic': [1873], 'Armel': [1875], 'H': [1878, 2046, 2192, 2195], 'Kim': [1880], 'Incidental': [1883], 'next': [1887, 2584], 'generation': [1888, 2585], 'panels,': [1890], 'npj': [1891], 'Genomic': [1892], 'Medicine,': [1893, 2300, 2462, 2640, 3008], '10.1038/s41525-021-00224-6,': [1894], '6:1,': [1895], 'Wolf': [1900], 'tumor': [1904], 'suppression': [1905], 'theory': [1906], 'Ageing': [1911], 'Development,': [1913], '10.1016/j.mad.2021.111583,': [1914], '200,': [1915], '(111583),': [1916], 'Wintrich': [1921], 'Berger': [1923], 'Bewarder': [1925], 'Emrich': [1927], 'Slawik': [1929], 'Böhm': [1932], 'M': [1933, 2152, 2341, 2363, 2469, 2550, 2578, 2651], 'Neues': [1935], 'zur': [1936], 'Diagnostik': [1937], 'und': [1938, 2686], 'Therapie': [1939], 'der': [1940], 'HerzinsuffizienzUpdate': [1941], 'diagnostics': [1943], 'treatment': [1945], 'heart': [1947], 'failure,': [1948], 'Herz,': [1949], '10.1007/s00059-021-05062-x': [1950], 'Soehnlein': [1951], 'O': [1952, 2257], 'P': [1955, 2284, 2440, 2547, 2631, 2743, 2909, 2931], 'Targeting': [1957], '—': [1961], 'insights': [1964], 'clinic,': [1967], 'Nature': [1968, 2620], 'Reviews': [1969, 2621], 'Drug': [1970], '10.1038/s41573-021-00198-1,': [1972], '20:8,': [1973], '(589-610),': [1974], '1-Aug-2021.': [1978], 'Yamamoto': [1979], 'Minami': [1981], 'Yoshida': [1983, 2967], 'Nagata': [1985], 'Miyata': [1987], 'Yang': [1989, 2253], 'Takayama': [1991], 'Suzuki': [1993], 'Okawa': [1995], 'Yamada': [1997], 'Miyamoto': [2000], 'Irradiation': [2003], 'Accelerates': [2004], 'Plaque': [2005], 'Formation': [2006], 'Cellular': [2008], 'Senescence': [2009], 'Flow‐Altered': [2011], 'Carotid': [2012], 'Arteries': [2013], 'Apolipoprotein': [2015], 'E': [2016, 2254, 2617], 'Knock‐Out': [2017], 'Mice,': [2018], 'Association,': [2024, 3082], '10:14,': [2025], '20-Jul-2021.': [2029], 'Leong': [2030], 'Aghel': [2032], 'Hillis': [2034], 'Siegal': [2036], 'Karampatos': [2038], 'Rangarajan': [2040], 'Pond': [2042], 'Seow': [2045], 'Tyrosine': [2048], 'inhibitors': [2050], 'leukaemia': [2054], 'emergent': [2056], 'disease,': [2058, 2940], 'Heart,': [2059], '10.1136/heartjnl-2020-318251,': [2060], '107:8,': [2061], '(667-673),': [2062], '1-Apr-2021.': [2066], 'X,': [2068], 'Pawlikowski': [2069], 'Olivo-Marston': [2071], 'Williams': [2073], 'Bower': [2075], 'Felix': [2077], 'Ferket': [2080], 'Ten-year': [2083], 'among': [2086], 'survivors:': [2088], 'National': [2090], 'Health': [2091], 'Nutrition': [2093], 'Examination': [2094], 'Survey,': [2095], 'PLOS': [2096], 'ONE,': [2097], '10.1371/journal.pone.0247919,': [2098], '16:3,': [2099], '(e0247919)': [2100], 'Yegorov': [2101], 'Poznyak': [2103], 'Nikiforov': [2105, 2863], 'Starodubova': [2107], 'Orekhov': [2110, 2874], 'Role': [2113], 'Telomeres': [2115, 2656, 2799], 'Shortening': [2116], 'Atherogenesis:': [2118], 'An': [2119], 'Overview,': [2120], 'Cells,': [2121, 3024], '10.3390/cells10020395,': [2122], '10:2,': [2123], '(395)': [2124], 'Bulaeva': [2125], 'Pellacani': [2127], 'Nakamichi': [2129], 'Hammond': [2131], 'Beer': [2133], 'Lorzadeh': [2135], 'Moksa': [2137], 'Carles': [2139], 'Bilenky': [2141], 'Lefort': [2143], 'Shu': [2145], 'Wilhelm': [2147], 'Weng': [2149], 'Hirst': [2151], 'Eaves': [2154], '(2020)': [2156, 2196, 2230, 2258, 2285, 2315, 2342, 2367, 2405, 2444, 2473, 2517, 2551], 'MYC-induced': [2157], 'leukemia': [2161], 'continuing': [2164], 'IL-3/GM-CSF': [2165], 'costimulus,': [2166], '10.1182/blood.2020006374,': [2168], '136:24,': [2169], '(2764-2773),': [2170], '10-Dec-2020.': [2174], 'Castiglione': [2175], 'Jiang': [2177], 'Mazzeo': [2179], 'Lee': [2181], 'Kaushansky': [2185], 'Yin': [2187], 'Zheng': [2191], 'Zhan': [2194], 'Endothelial': [2197], 'JAK2V617F': [2198], 'leads': [2200], 'thrombosis,': [2202], 'vasculopathy,': [2203], 'cardiomyopathy': [2205], 'murine': [2208], 'model': [2209], 'neoplasm,': [2212], 'Thrombosis': [2215], 'Haemostasis,': [2217], '10.1111/jth.15095,': [2218], '18:12,': [2219], '(3359-3370),': [2220], '1-Dec-2020.': [2224, 2248], 'Moran': [2225], 'Plana': [2228], 'Management': [2231], 'Patients': [2233], 'Acute': [2235], 'Coronary': [2236], 'Syndrome': [2237], 'Cancer,': [2239], 'Reports,': [2242, 2269], '10.1007/s11886-020-01409-8,': [2243], '22:12,': [2244], 'Kumar': [2249], 'Kopecky': [2251], 'Oren': [2256], 'Disease,': [2266, 2414, 2662], 'Oncology': [2268], '10.1007/s11912-020-00955-2,': [2270], '22:9,': [2271], '1-Sep-2020.': [2275], 'Hoermann': [2276], 'Greiner': [2278], 'Griesmacher': [2280], 'Valent': [2283], 'Potential:': [2290], 'Multidisciplinary': [2292], 'Challenge': [2293], 'Personalized': [2295, 2299], 'Hematology,': [2296, 2491], '10.3390/jpm10030094,': [2301], '10:3,': [2302], '(94)': [2303], 'Stojanović': [2304], 'Fiedler': [2306], 'Bauersachs': [2308], 'Thum': [2310], 'Sedding': [2313], 'Senescence-induced': [2316], 'inflammation:': [2317], 'player': [2320], 'therapeutic': [2323, 2753], 'European': [2327, 2383], 'Journal,': [2329], '10.1093/eurheartj/ehz919,': [2330], '41:31,': [2331], '(2983-2996),': [2332], '14-Aug-2020.': [2336], 'Bekele': [2337], 'Patnaik': [2340], 'Autoimmunity,': [2343], 'Hematopoiesis,': [2345, 2848], 'Myeloid': [2347], 'Neoplasms,': [2348], 'Rheumatic': [2349], 'Disease': [2350, 2622], 'Clinics': [2351], 'North': [2353], 'America,': [2354], '10.1016/j.rdc.2020.03.001,': [2355], '46:3,': [2356], '(429-444),': [2357], '1-Aug-2020.': [2361, 2391], 'Kanayama': [2362], 'Luo': [2365], 'Predictive': [2368], 'Biomarkers': [2369, 2407], 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'10.1080/14779072.2020.1718493,': [2565], '18:1,': [2566], '(25-32),': [2567], '2-Jan-2020.': [2571], 'Spaulding': [2572], 'Stockton': [2574], 'Savona': [2577], '(2019)': [2579, 2618, 2632, 2655, 2680, 2709, 2747, 2793, 2846, 2876, 2935, 2994, 3017], 'evolving': [2581], 'role': [2582], 'syndromes,': [2589], 'British': [2590], 'Haematology,': [2593], '10.1111/bjh.16212,': [2594], '188:2,': [2595], '(224-239),': [2596], '1-Jan-2020.': [2600], 'Buring': [2603], 'Badimon': [2605], 'Hansson': [2607], 'Deanfield': [2609], 'Bittencourt': [2611], 'Tokgözoğlu': [2613], 'Lewis': [2616], 'Primers,': [2623], '10.1038/s41572-019-0106-z,': [2624], '5:1,': [2625], '1-Dec-2019.': [2629], 'Shah': [2630, 2930], 'infection': [2634], 'Trends': [2637], '10.1016/j.tcm.2019.01.004,': [2641], '29:8,': [2642], '(468-472),': [2643], '1-Nov-2019.': [2647, 2674], 'Yeh': [2648], 'Therapeutic': [2658, 2761], 'Targets': [2659], 'JACC:': [2663], 'Basic': [2664], 'Translational': [2666], 'Science,': [2667], 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'pathway:': [2750], 'novel': [2752], 'diseases?,': [2757], 'Opinion': [2759], 'Targets,': [2762], '10.1080/14728222.2019.1641198,': [2763], '23:8,': [2764], '(695-710),': [2765], '3-Aug-2019.': [2769], 'Chiriacò': [2770], 'Georgiopoulos': [2772], 'Duranti': [2774], 'Antonioli': [2776], 'Puxeddu': [2778], 'Nannipieri': [2780], 'Rosada': [2782], 'Blandizzi': [2784], 'Taddei': [2786], 'Virdis': [2788], 'Masi': [2791], 'Ageing:': [2797], 'Novel': [2801], 'Emerging': [2802], 'Mechanisms,': [2803], 'High': [2804], 'Blood': [2805], 'Pressure': [2806], '&': [2807], 'Prevention,': [2809], '10.1007/s40292-019-00331-7,': [2810], '26:4,': [2811], '(321-329),': [2812], '1-Aug-2019.': [2816], 'Sidlow': [2819], 'Jones': [2825], 'Moslehi': [2827], 'Zeiher': [2829], 'Schulz': [2833], 'Blankstein': [2835], 'Bolton': [2837], 'Levine': [2841], '10.1016/j.jacc.2019.06.007,': [2856], '74:4,': [2857], '(567-577),': [2858], '1-Jul-2019.': [2862], 'Wetzker': [2865], 'Kubekina': [2867], 'Petukhova': [2869], 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