Publication Information

{'id': 'https://openalex.org/W2777316642', 'doi': 'https://doi.org/10.12793/tcp.2017.25.4.196', 'title': 'Comparison of pharmacokinetics and safety of fixed-dose combination of SKI306X and aceclofenac versus separate tablets in healthy subjects', 'display_name': 'Comparison of pharmacokinetics and safety of fixed-dose combination of SKI306X and aceclofenac versus separate tablets in healthy subjects', 'publication_year': 2017, 'publication_date': '2017-01-01', 'ids': {'openalex': 'https://openalex.org/W2777316642', 'doi': 'https://doi.org/10.12793/tcp.2017.25.4.196', 'mag': '2777316642', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32095475', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7033402'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.12793/tcp.2017.25.4.196', 'pdf_url': 'http://synapse.koreamed.org/Synapse/Data/PDFData/1179TCP/tcp-25-196.pdf', 'source': {'id': 'https://openalex.org/S4210230709', 'display_name': 'Translational and Clinical Pharmacology', 'issn_l': '2289-0882', 'issn': ['2289-0882', '2383-5427'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://synapse.koreamed.org/Synapse/Data/PDFData/1179TCP/tcp-25-196.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066341595', 'display_name': 'Xue Meng', 'orcid': 'https://orcid.org/0009-0007-0267-3187'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Xue Meng', 'raw_affiliation_strings': ['Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103453104', 'display_name': 'Eun Sil Oh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Eun Sil Oh', 'raw_affiliation_strings': ['Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966', 'https://openalex.org/I2799970807']}, {'raw_affiliation_string': 'Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000422222', 'display_name': 'Min Soo Park', 'orcid': 'https://orcid.org/0000-0002-4395-9938'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Min Soo Park', 'raw_affiliation_strings': ['Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073740836', 'display_name': 'Dasohm Kim', 'orcid': 'https://orcid.org/0000-0002-7925-194X'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Dasohm Kim', 'raw_affiliation_strings': ['Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966', 'https://openalex.org/I2799970807']}, {'raw_affiliation_string': 'Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075850357', 'display_name': 'Sae Min Kwon', 'orcid': 'https://orcid.org/0000-0001-9720-6037'}, 'institutions': [{'id': 'https://openalex.org/I134353371', 'display_name': 'SK Group (South Korea)', 'ror': 'https://ror.org/03696td91', 'country_code': 'KR', 'type': 'company', 'lineage': ['https://openalex.org/I134353371']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong Hoon Kim', 'raw_affiliation_strings': ['Head of Pharma R&D Center, Life Science Business Group, SK Chemicals, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Head of Pharma R&D Center, Life Science Business Group, SK Chemicals, Republic of Korea.', 'institution_ids': ['https://openalex.org/I134353371']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085332322', 'display_name': 'Choon Ok Kim', 'orcid': 'https://orcid.org/0000-0002-2319-1108'}, 'institutions': [{'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}, {'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Choon Ok Kim', 'raw_affiliation_strings': ['Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.55896, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 75, 'max': 78}, 'biblio': {'volume': '25', 'issue': '4', 'first_page': '196', 'last_page': '196'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis and Cartilage Repair', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aceclofenac', 'display_name': 'Aceclofenac', 'score': 0.9931271}, {'id': 'https://openalex.org/keywords/fixed-dose-combination', 'display_name': 'Fixed-dose combination', 'score': 0.82950777}, {'id': 'https://openalex.org/keywords/crossover-study', 'display_name': 'Crossover study', 'score': 0.5766575}, {'id': 'https://openalex.org/keywords/bioequivalence', 'display_name': 'Bioequivalence', 'score': 0.51908016}, {'id': 'https://openalex.org/keywords/joint', 'display_name': 'Joint', 'score': 0.450303}], 'concepts': [{'id': 'https://openalex.org/C2780976021', 'wikidata': 'https://www.wikidata.org/wiki/Q481757', 'display_name': 'Aceclofenac', 'level': 2, 'score': 0.9931271}, {'id': 'https://openalex.org/C2776623344', 'wikidata': 'https://www.wikidata.org/wiki/Q5456317', 'display_name': 'Fixed-dose combination', 'level': 2, 'score': 0.82950777}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.76813585}, {'id': 'https://openalex.org/C22979827', 'wikidata': 'https://www.wikidata.org/wiki/Q5137311', 'display_name': 'Cmax', 'level': 3, 'score': 0.6682941}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.59978205}, {'id': 'https://openalex.org/C87813604', 'wikidata': 'https://www.wikidata.org/wiki/Q1242899', 'display_name': 'Crossover study', 'level': 4, 'score': 0.5766575}, {'id': 'https://openalex.org/C42404028', 'wikidata': 'https://www.wikidata.org/wiki/Q864940', 'display_name': 'Bioequivalence', 'level': 3, 'score': 0.51908016}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.50499994}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37024832}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.08062595}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.12793/tcp.2017.25.4.196', 'pdf_url': 'http://synapse.koreamed.org/Synapse/Data/PDFData/1179TCP/tcp-25-196.pdf', 'source': {'id': 'https://openalex.org/S4210230709', 'display_name': 'Translational and Clinical Pharmacology', 'issn_l': '2289-0882', 'issn': ['2289-0882', '2383-5427'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7033402', 'pdf_url': 'https://europepmc.org/articles/pmc7033402?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033402', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32095475', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.12793/tcp.2017.25.4.196', 'pdf_url': 'http://synapse.koreamed.org/Synapse/Data/PDFData/1179TCP/tcp-25-196.pdf', 'source': {'id': 'https://openalex.org/S4210230709', 'display_name': 'Translational and Clinical Pharmacology', 'issn_l': '2289-0882', 'issn': ['2289-0882', '2383-5427'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320322107', 'funder_display_name': 'Korea Health Industry Development Institute', 'award_id': 'HI14C1062'}], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1968357969', 'https://openalex.org/W1975503974', 'https://openalex.org/W1979622703', 'https://openalex.org/W1988661248', 'https://openalex.org/W1993641455', 'https://openalex.org/W2038917994', 'https://openalex.org/W2044581275', 'https://openalex.org/W2059335047', 'https://openalex.org/W2094625675', 'https://openalex.org/W2119647028', 'https://openalex.org/W2120762957', 'https://openalex.org/W2128882188', 'https://openalex.org/W2161736885', 'https://openalex.org/W2172883781', 'https://openalex.org/W2566448124', 'https://openalex.org/W2753598112', 'https://openalex.org/W2979571235'], 'related_works': ['https://openalex.org/W806298471', 'https://openalex.org/W4296918699', 'https://openalex.org/W2950351041', 'https://openalex.org/W2914400490', 'https://openalex.org/W2787516851', 'https://openalex.org/W2431224659', 'https://openalex.org/W2187179074', 'https://openalex.org/W2087796686', 'https://openalex.org/W2082887863', 'https://openalex.org/W151882183'], 'abstract_inverted_index': {'JOINS': [0], '(SKI306X)': [1], 'is': [2, 8], 'an': [3], 'herbal': [4], 'anti-arthritic': [5], 'medicine': [6], 'that': [7], 'widely': [9], 'used': [10], 'with': [11, 47], 'aceclofenac': [12, 26, 53, 87, 108], 'for': [13], 'treating': [14], 'osteoarthritis': [15], 'in': [16, 54, 127], 'Korea.': [17], 'A': [18, 118], 'fixed-dose': [19], 'combination': [20], '(FDC)': [21], 'tablet': [22, 46, 67], 'containing': [23], 'SKI306X': [24, 51, 82], 'and': [25, 41, 52, 83, 102, 111, 128], 'was': [27, 74, 89, 113], 'developed': [28], 'to': [29, 36, 106], 'improve': [30], 'patient': [31], 'compliance.': [32], 'This': [33], 'study': [34], 'aimed': [35], 'compare': [37], 'the': [38, 44, 65, 116, 130], 'pharmacokinetics': [39], '(PK)': [40], 'safety': [42, 112], 'of': [43, 49, 78, 81, 86, 120], 'FDC': [45, 66], 'those': [48], 'co-administered': [50], 'healthy': [55, 122], 'subjects.': [56], 'In': [57], 'this': [58], 'randomized,': [59], 'open-label,': [60], 'two-way': [61], 'crossover,': [62], 'single-dose': [63], 'study,': [64], '(SKI306X': [68], '300': [69, 79], 'mg/aceclofenac': [70], '100': [71, 84], 'mg)': [72], '(test)': [73], 'given': [75], 'or': [76], 'co-administration': [77], 'mg': [80, 85], '(reference)': [88], 'performed': [90], 'followed': [91], 'by': [92], 'a': [93], '7-day': [94], 'wash-out': [95], 'period.': [96], 'Blood': [97], 'samples': [98], 'were': [99, 125], 'collected': [100], 'before': [101], 'after': [103], 'drug': [104], 'administration': [105], 'evaluate': [107], 'PK': [109], 'parameters,': [110], 'assessed': [114], 'throughout': [115], 'study.': [117, 131], 'total': [119], '54': [121], 'male': [123], 'subjects': [124], 'enrolled': [126], 'completed': [129], 'T': [132]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2777316642', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-09-26T05:37:24.314686', 'created_date': '2018-01-05'}