Publication Information

{'id': 'https://openalex.org/W2770460924', 'doi': 'https://doi.org/10.1002/anie.201711143', 'title': 'Quaternary β<sup>2,2</sup>‐Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc‐Based Solid‐Phase Peptide Synthesis', 'display_name': 'Quaternary β<sup>2,2</sup>‐Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc‐Based Solid‐Phase Peptide Synthesis', 'publication_year': 2017, 'publication_date': '2017-11-23', 'ids': {'openalex': 'https://openalex.org/W2770460924', 'doi': 'https://doi.org/10.1002/anie.201711143', 'mag': '2770460924', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29168280'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/anie.201711143', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S67393510', 'display_name': 'Angewandte Chemie International Edition', 'issn_l': '1433-7851', 'issn': ['1433-7851', '1521-3773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047207947', 'display_name': 'Jin‐Sheng Yu', 'orcid': 'https://orcid.org/0000-0002-0619-2037'}, 'institutions': [{'id': 'https://openalex.org/I4210111963', 'display_name': 'Microbial Chemistry Research Foundation', 'ror': 'https://ror.org/02bwxve09', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111963']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Jin‐Sheng Yu', 'raw_affiliation_strings': ['Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan'], 'affiliations': [{'raw_affiliation_string': 'Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan', 'institution_ids': ['https://openalex.org/I4210111963']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028359173', 'display_name': 'Hidetoshi Noda', 'orcid': 'https://orcid.org/0000-0001-6529-8870'}, 'institutions': [{'id': 'https://openalex.org/I4210111963', 'display_name': 'Microbial Chemistry Research Foundation', 'ror': 'https://ror.org/02bwxve09', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111963']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hidetoshi Noda', 'raw_affiliation_strings': ['Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan'], 'affiliations': [{'raw_affiliation_string': 'Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan', 'institution_ids': ['https://openalex.org/I4210111963']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012101296', 'display_name': 'Masakatsu Shibasaki', 'orcid': 'https://orcid.org/0000-0001-8862-582X'}, 'institutions': [{'id': 'https://openalex.org/I4210111963', 'display_name': 'Microbial Chemistry Research Foundation', 'ror': 'https://ror.org/02bwxve09', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111963']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Masakatsu Shibasaki', 'raw_affiliation_strings': ['Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan'], 'affiliations': [{'raw_affiliation_string': 'Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan', 'institution_ids': ['https://openalex.org/I4210111963']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5047207947', 'https://openalex.org/A5028359173', 'https://openalex.org/A5012101296'], 'corresponding_institution_ids': ['https://openalex.org/I4210111963', 'https://openalex.org/I4210111963', 'https://openalex.org/I4210111963'], 'apc_list': {'value': 5250, 'currency': 'USD', 'value_usd': 5250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.323, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 65, 'citation_normalized_percentile': {'value': 0.813541, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '57', 'issue': '3', 'first_page': '818', 'last_page': '822'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10911', 'display_name': 'Peptide Synthesis and Drug Discovery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10911', 'display_name': 'Peptide Synthesis and Drug Discovery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10013', 'display_name': 'Asymmetric Catalysis', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12251', 'display_name': 'Catalytic C-H Amination Reactions', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amide', 'display_name': 'Amide', 'score': 0.5680396}, {'id': 'https://openalex.org/keywords/asymmetric-synthesis', 'display_name': 'Asymmetric Synthesis', 'score': 0.562827}, {'id': 'https://openalex.org/keywords/peptide-synthesis', 'display_name': 'Peptide Synthesis', 'score': 0.553699}, {'id': 'https://openalex.org/keywords/amide-bond-formation', 'display_name': 'Amide Bond Formation', 'score': 0.533783}, {'id': 'https://openalex.org/keywords/solid-phase-synthesis', 'display_name': 'Solid-Phase Synthesis', 'score': 0.511824}], 'concepts': [{'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.8381177}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7259923}, {'id': 'https://openalex.org/C2779809887', 'wikidata': 'https://www.wikidata.org/wiki/Q14864278', 'display_name': 'Peptide synthesis', 'level': 3, 'score': 0.68160343}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.64321506}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.6209779}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.6175991}, {'id': 'https://openalex.org/C2778439535', 'wikidata': 'https://www.wikidata.org/wiki/Q188777', 'display_name': 'Amide', 'level': 2, 'score': 0.5680396}, {'id': 'https://openalex.org/C2776469878', 'wikidata': 'https://www.wikidata.org/wiki/Q2026994', 'display_name': 'Solid-phase synthesis', 'level': 3, 'score': 0.51486385}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.33265266}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.32435304}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12449351}], 'mesh': [{'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D005449', 'descriptor_name': 'Fluorenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D060327', 'descriptor_name': 'Solid-Phase Synthesis Techniques', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003653', 'descriptor_name': 'Decarboxylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005449', 'descriptor_name': 'Fluorenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010165', 'descriptor_name': 'Palladium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010165', 'descriptor_name': 'Palladium', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D060327', 'descriptor_name': 'Solid-Phase Synthesis Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/anie.201711143', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S67393510', 'display_name': 'Angewandte Chemie International Edition', 'issn_l': '1433-7851', 'issn': ['1433-7851', '1521-3773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29168280', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': 'JP16K18856'}, {'funder': 'https://openalex.org/F4320338114', 'funder_display_name': 'Creations of Advanced Catalytic Transformation for the Sustainable Manufacturing at Low Energy, Low Environmental Load', 'award_id': 'JPMJCR12YO'}], 'datasets': ['https://openalex.org/W4397403772'], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1501359805', 'https://openalex.org/W1971636489', 'https://openalex.org/W1975775855', 'https://openalex.org/W1978713271', 'https://openalex.org/W1986001811', 'https://openalex.org/W1987731391', 'https://openalex.org/W1991340608', 'https://openalex.org/W1996711784', 'https://openalex.org/W1999465043', 'https://openalex.org/W2010954863', 'https://openalex.org/W2012437706', 'https://openalex.org/W2012822924', 'https://openalex.org/W2012860621', 'https://openalex.org/W2016772784', 'https://openalex.org/W2021198082', 'https://openalex.org/W2031935437', 'https://openalex.org/W2036758375', 'https://openalex.org/W2042584758', 'https://openalex.org/W2044374737', 'https://openalex.org/W2044865569', 'https://openalex.org/W2049095005', 'https://openalex.org/W2055079700', 'https://openalex.org/W2055884298', 'https://openalex.org/W2056918820', 'https://openalex.org/W2084617754', 'https://openalex.org/W2086167852', 'https://openalex.org/W2090600061', 'https://openalex.org/W2091183183', 'https://openalex.org/W2101727553', 'https://openalex.org/W2101738574', 'https://openalex.org/W2108762552', 'https://openalex.org/W2113427587', 'https://openalex.org/W2129539806', 'https://openalex.org/W2133521470', 'https://openalex.org/W2134114358', 'https://openalex.org/W2139411610', 'https://openalex.org/W2141133944', 'https://openalex.org/W2151718271', 'https://openalex.org/W2164098118', 'https://openalex.org/W2166454514', 'https://openalex.org/W2171647007', 'https://openalex.org/W2180667062', 'https://openalex.org/W2254963963', 'https://openalex.org/W2272368254', 'https://openalex.org/W2315281451', 'https://openalex.org/W2322877829', 'https://openalex.org/W2334928987', 'https://openalex.org/W2389047281', 'https://openalex.org/W2462615990', 'https://openalex.org/W2468230863', 'https://openalex.org/W2520253973', 'https://openalex.org/W2540998518', 'https://openalex.org/W2576817183', 'https://openalex.org/W2592346966', 'https://openalex.org/W2624724436', 'https://openalex.org/W2751492513', 'https://openalex.org/W2949448189', 'https://openalex.org/W2953116453', 'https://openalex.org/W4205885883', 'https://openalex.org/W4242649193', 'https://openalex.org/W4245860150', 'https://openalex.org/W4248737905', 'https://openalex.org/W4253200406'], 'related_works': ['https://openalex.org/W578366578', 'https://openalex.org/W2616177209', 'https://openalex.org/W2500981667', 'https://openalex.org/W2290860739', 'https://openalex.org/W2162909614', 'https://openalex.org/W2045562868', 'https://openalex.org/W2040079612', 'https://openalex.org/W2032740856', 'https://openalex.org/W2032732399', 'https://openalex.org/W2009122906'], 'abstract_inverted_index': {'β-Amino': [0], 'acid': [1], 'incorporation': [2, 69], 'has': [3], 'emerged': [4], 'as': [5, 101], 'a': [6, 34, 102], 'promising': [7], 'approach': [8], 'to': [9, 17, 23, 29, 125], 'enhance': [10], 'the': [11, 24, 46, 59, 85, 96], 'stability': [12], 'of': [13, 26, 48, 63, 89], 'parent': [14], 'peptides': [15, 71], 'and': [16, 51, 67], 'improve': [18], 'their': [19, 68], 'biological': [20], 'activity.': [21], 'Owing': [22], 'lack': [25], 'reliable': [27], 'access': [28, 124], 'β2,2': [30, 64], '-amino': [31, 54, 65], 'acids': [32, 66, 108], 'in': [33, 95], 'setting': [35], 'suitable': [36], 'for': [37, 106, 129], 'peptide': [38, 75], 'synthesis,': [39], 'most': [40], 'contemporary': [41], 'research': [42], 'efforts': [43], 'focus': [44], 'on': [45], 'use': [47], 'β3': [49], '-': [50], 'certain': [52], 'β2,3': [53], 'acids.': [55], 'Herein,': [56], 'we': [57], 'report': [58], 'catalytic': [60], 'asymmetric': [61], 'synthesis': [62, 76], 'into': [70], 'by': [72, 84], 'Fmoc-based': [73], 'solid-phase': [74], '(Fmoc-SPPS).': [77], 'A': [78], 'quaternary': [79], 'carbon': [80], 'center': [81], 'was': [82], 'constructed': [83], 'palladium-catalyzed': [86], 'decarboxylative': [87], 'allylation': [88], '4-substituted': [90], 'isoxazolidin-5-ones.': [91], 'The': [92], 'N-O': [93], 'bond': [94], 'products': [97], 'not': [98], 'only': [99], 'acts': [100], 'traceless': [103], 'protecting': [104], 'group': [105], 'β-amino': [107], 'but': [109], 'also': [110], 'undergoes': [111], 'amide': [112], 'formation': [113], 'with': [114], 'α-ketoacids': [115], 'derived': [116], 'from': [117], 'Fmoc-protected': [118], 'α-amino': [119], 'acids,': [120], 'thus': [121], 'providing': [122], 'expeditious': [123], 'α-β2,2': [126], '-dipeptides': [127], 'ready': [128], 'Fmoc-SPPS.': [130]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2770460924', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 6}], 'updated_date': '2024-09-27T04:06:54.136074', 'created_date': '2017-12-04'}