Publication Information

{'id': 'https://openalex.org/W2611821716', 'doi': 'https://doi.org/10.4314/tjpr.v16i4.26', 'title': 'Clinical effect of combined ulinastatin and continuous renal replacement therapy on management of severe sepsis with acute kidney injury', 'display_name': 'Clinical effect of combined ulinastatin and continuous renal replacement therapy on management of severe sepsis with acute kidney injury', 'publication_year': 2017, 'publication_date': '2017-05-05', 'ids': {'openalex': 'https://openalex.org/W2611821716', 'doi': 'https://doi.org/10.4314/tjpr.v16i4.26', 'mag': '2611821716'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4314/tjpr.v16i4.26', 'pdf_url': 'https://www.ajol.info/index.php/tjpr/article/download/155554/145183', 'source': {'id': 'https://openalex.org/S174262287', 'display_name': 'Tropical Journal of Pharmaceutical Research', 'issn_l': '1596-9827', 'issn': ['1596-9827', '1596-5996'], 'is_oa': True, 'is_in_doaj': True, 'is_core': 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'https://openalex.org/W804472724'], 'related_works': ['https://openalex.org/W4382789480', 'https://openalex.org/W3186007354', 'https://openalex.org/W3185971308', 'https://openalex.org/W3163602829', 'https://openalex.org/W2753431208', 'https://openalex.org/W2611821716', 'https://openalex.org/W2357267871', 'https://openalex.org/W2355383717', 'https://openalex.org/W2171483342', 'https://openalex.org/W135164154'], 'abstract_inverted_index': {'Purpose:': [0], 'To': [1], 'explore': [2], 'the': [3, 17, 42, 71, 77, 184, 193, 214, 221, 237, 251], 'effect': [4], 'of': [5, 8, 19, 47, 50, 102, 115, 145, 266, 276, 280, 285], 'a': [6, 80, 272], 'combination': [7], 'ulinastatin': [9, 107, 197, 258], 'and': [10, 57, 64, 91, 122, 129, 139, 177, 208, 283, 287], 'continuous': [11], 'renal': [12, 286, 292], 'replacement': [13, 293], 'therapy': [14], '(CRRT)': [15], 'for': [16, 29, 110], 'treatment': [18, 63, 82, 96, 185, 198, 215, 225], 'severe': [20], 'sepsis': [21], 'with': [22, 33, 260], 'acute': [23], 'kidney': [24, 121, 179, 297], 'injury': [25, 180], '(SAKI).Methods:': [26], 'Clinical': [27], 'data': [28], '106': [30], 'patients': [31, 78, 94, 270], 'diagnosed': [32], 'SAKI': [34, 269], 'from': [35], 'April': [36], '2013': [37], 'to': [38], 'May': [39], '2015': [40], 'in': [41, 95, 183, 192, 213, 220, 236, 247, 268], 'intensive': [43], 'care': [44], 'unit': [45], '(ICU)': [46], 'Affiliated': [48], 'Hospital': [49], 'Zhengzhou': [51], 'University,': [52], 'Zhengzhou,': [53], 'China,': [54], 'were': [55, 74, 126, 142, 187, 217, 234, 243], 'collected': [56], 'randomly': [58], 'assigned': [59], 'into': [60], 'two': [61, 72, 238, 252], 'groups:': [62], 'control': [65, 194, 222], 'groups.': [66, 239], 'The': [67, 93], 'general': [68], 'information': [69], 'on': [70], 'groups': [73], 'comparable.': [75], 'All': [76], 'received': [79, 99], 'comprehensive': [81], 'program': [83], 'which': [84], 'included': [85], 'fluid': [86], 'resuscitation,': [87], 'antibiotics,': [88], 'nutritional': [89], 'support': [90], 'CRRT.': [92], 'group': [97, 186, 195, 216, 223], 'also': [98], 'intravenous': [100], 'injection': [101], '300': [103], 'thousand': [104], 'units/10': [105], 'mL': [106], 'thrice': [108], 'daily': [109], '5': [111], 'days.': [112], 'Serum': [113], 'levels': [114, 265], 'inflammatory': [116], 'cytokines,': [117], 'oxidative': [118, 281], 'stress': [119], 'level,': [120], 'blood': [123, 162], 'coagulation': [124, 288], 'functions': [125], 'assayed': [127], 'before': [128], 'after': [130, 196, 224], 'treatment,': [131], 'using': [132], 'standard': [133], 'methodologies.': [134], 'In': [135, 240], 'addition,': [136, 241], 'adverse': [137, 231], 'reactions': [138, 233], '28-day': [140, 248], 'mortality': [141, 249], 'recorded.Results:': [143], 'Levels': [144], 'interleukin-6': [146], '(IL-6),': [147], 'tumor': [148], 'necrosis': [149], 'factor': [150], 'α': [151], '(TNFα),': [152], 'serum': [153, 174, 264], 'C-reactive': [154], 'protein': [155], '(CRP),': [156], 'procalcitonin': [157], '(PCT),': [158], 'malondialdehyde': [159], '(MDA),': [160], 'cystatin,': [161], 'urea': [163], 'nitrogen': [164], '(BUN),': [165], 'prothrombin': [166], 'time': [167, 172], '(PT),': [168], 'activated': [169], 'partial': [170], 'thromboplastin': [171], '(APTT),': [173], 'creatinine': [175], '(SCr)': [176], 'urinary': [178], 'molecule-1': [181], '(Kim-1)': [182], 'significantly': [188, 218], 'lower': [189], 'than': [190], 'those': [191], '(p': [199, 226], '<': [200, 227], '0.05).': [201, 228], 'However,': [202], 'superoxide': [203], 'dismutase': [204], '(SOD),': [205], 'fibrinogen': [206], '(Fib)': [207], 'total': [209], 'antioxidant': [210, 277], 'capacity': [211], '(T-AOC)': [212], 'higher': [219], 'No': [229], 'serious': [230], 'drug': [232], 'seen': [235], 'there': [242], 'no': [244], 'significant': [245], 'differences': [246], 'between': [250], 'groups.Conclusion:': [253], 'These': [254], 'results': [255], 'suggest': [256], 'that': [257], 'combined': [259], 'CRRT': [261], 'effectively': [262], 'decreases': [263], 'inflammation': [267], 'through': [271], 'mechanism': [273], 'involving': [274], 'improvement': [275], 'capacity,': [278], 'reduction': [279], 'stress,': [282], 'enhancement': [284], 'functions.Keywords:': [289], 'Ulinastatin,': [290], 'Continuous': [291], 'therapy,': [294], 'Sepsis,': [295], 'Acute': [296], 'injury,': [298], 'Inflammatory': [299], 'cytokines': [300]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2611821716', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-26T00:37:44.156658', 'created_date': '2017-05-12'}