O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3

Name: O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3
Uploaded: 2017-04-28
Donglu Wu; Linhong Zhao; Zhitong Feng; Chao Yu; Jian Ding; Lingyao Wang; Fei Wang; Da Liu; Huihui Zhu; Feiyang Xing; Joan Conaway; Ronald Conaway; Yong Cai; Jingji Jin
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379, 410], 'transferase': [30, 133, 187, 254, 357, 411], 'activity': [31, 37, 62, 216, 255, 261, 286, 440], 'of': [32, 38, 63, 80, 99, 112, 121, 154, 163, 177, 191, 201, 217, 256, 262, 287, 304, 323, 336, 345, 378, 387, 401, 415, 425, 441], 'OGT1': [33, 44, 59, 90, 108, 122, 137, 167, 181, 213, 257, 268, 283, 314, 332, 346, 361, 391, 405, 437], 'controls': [34, 258], 'NSL': [40, 50, 65, 82, 114, 219, 264, 274, 289, 306, 338, 443], 'and': [42, 74, 78, 105, 141, 205, 266, 298, 302, 329, 365, 429], 'physically': [45, 269], 'interacts': [46, 270], 'with': [47, 129, 179, 271, 353, 403], 'other': [49, 273], 'remain': [53, 277], 'unclear.': [54, 278], 'Here,': [55, 279], 'we': [56, 116, 280, 340], 'demonstrate': [57, 281], 'that': [58, 136, 184, 212, 282, 360, 408, 436], 'regulates': [60, 214, 284, 438], 'by': [67, 165, 193, 221, 291, 389, 417, 445], 'mainly': [68, 292], 'acetylating': [69, 293], 'H4': [71, 101, 202, 295, 325, 426], 'Lys-16,': [72, 103, 296, 327], 'Lys-5,': [73, 104, 203, 297, 328, 427], 'Lys-8': [75, 299], 'via': [76, 300], 'O-GlcNAcylation': [77, 162, 301, 386], 'stabilization': [79, 172, 190, 303, 396, 414], 'subunit': [84, 111, 308, 335], 'NSL3.': [85, 143, 170, 223, 309, 367, 394, 447], 'Knocking': [86, 310], 'down': [87, 311], 'or': [88, 312], 'overexpressing': [89, 313], 'in': [91, 123, 130, 159, 207, 315, 347, 354, 383, 431], 'cells': [93, 317], 'remarkably': [94, 318], 'affected': [95, 319], 'global': [97, 198, 321, 422], 'acetylation': [98, 199, 322, 423], 'residues': [102, 326], 'Lys-8.': [106, 330], 'Because': [107, 331], 'is': [109, 333], 'a': [110, 334], 'complex,': [115, 339], 'also': [117, 341], 'investigated': [118, 342], 'function': [120, 344], 'this': [124, 348], 'complex.': [125, 349], 'Co-transfection/co-immunoprecipitation': [126, 350], 'experiments': [127, 351], 'combined': [128, 352], 'vitro': [131, 355], 'assays': [134, 358], 'confirmed': [135, 359], 'specifically': [138, 362], 'binds': [139, 363], 'to': [140, 364], 'O-GlcNAcylates': [142, 366], 'In': [144, 368], 'addition,': [145, 369], 'wheat': [146, 370], 'germ': [147, 371], 'agglutinin': [148, 372], 'affinity': [149, 373], 'purification': [150, 374], 'verified': [151, 375], 'occurrence': [153, 377], 'modification': [156, 380], 'NSL3': [158, 164, 178, 192, 382, 388, 402, 416], 'cells.': [160, 208, 384, 432], 'Moreover,': [161, 385], 'wild-type': [166, 390], '(OGT1-WT)': [168, 392], 'stabilized': [169, 393], 'This': [171, 395], 'was': [173, 397], 'lost': [174, 398], 'after': [175, 399], 'co-transfection': [176, 400], 'an': [180, 404], 'mutant,': [182, 406], 'OGT1C964A,': [183, 407], 'lacks': [185, 409], 'activity.': [188, 412], 'Furthermore,': [189, 413], 'OGT1-WT': [194, 418], 'significantly': [195, 419], 'increased': [196, 420], 'levels': [200, 424], 'Lys-8,': [204, 428], 'Lys-16': [206, 430], 'These': [209, 433], 'results': [210, 434], 'suggest': [211, 435], 'stabilizing': [222, 446]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2609952269', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-24T16:15:42.631664', 'created_date': '2017-05-05'}
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