Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2572123927', 'doi': 'https://doi.org/10.1002/cbf.3246', 'title': 'Small animal models to understand pathogenesis of osteoarthritis and use of stem cell in cartilage regeneration', 'display_name': 'Small animal models to understand pathogenesis of osteoarthritis and use of stem cell in cartilage regeneration', 'publication_year': 2017, 'publication_date': '2017-01-01', 'ids': {'openalex': 'https://openalex.org/W2572123927', 'doi': 'https://doi.org/10.1002/cbf.3246', 'mag': '2572123927', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28083966'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cbf.3246', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S960618578', 'display_name': 'Cell Biochemistry and Function', 'issn_l': '0263-6484', 'issn': ['0263-6484', '1099-0844'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.repository.cam.ac.uk/bitstreams/bae7842f-1b57-488a-a141-7e782ab52e7c/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081527293', 'display_name': 'Virginia Piombo', 'orcid': 'https://orcid.org/0000-0002-2698-3370'}, 'institutions': [{'id': 'https://openalex.org/I4210156194', 'display_name': "Addenbrooke's Hospital", 'ror': 'https://ror.org/055vbxf86', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802466933', 'https://openalex.org/I4210156194']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Virginia Piombo', 'raw_affiliation_strings': ["Division of Trauma and Orthopaedic Surgery, Addenbrooke's Hospital, Cambridge, Cambridgeshire, UK"], 'affiliations': [{'raw_affiliation_string': "Division of Trauma and Orthopaedic Surgery, Addenbrooke's Hospital, Cambridge, Cambridgeshire, UK", 'institution_ids': ['https://openalex.org/I4210156194']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5081527293'], 'corresponding_institution_ids': ['https://openalex.org/I4210156194'], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.059, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.164077, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 80}, 'biblio': {'volume': '35', 'issue': '1', 'first_page': '3', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis and Cartilage Repair', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis and Cartilage Repair', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10176', 'display_name': 'Multipotent Mesenchymal Stem Cells', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10442', 'display_name': 'Anterior Cruciate Ligament Injuries in Athletes', 'score': 0.9772, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/knee-osteoarthritis', 'display_name': 'Knee Osteoarthritis', 'score': 0.510797}, {'id': 'https://openalex.org/keywords/synovial-joint', 'display_name': 'Synovial joint', 'score': 0.5072691}], 'concepts': [{'id': 'https://openalex.org/C2776164576', 'wikidata': 'https://www.wikidata.org/wiki/Q62736', 'display_name': 'Osteoarthritis', 'level': 3, 'score': 0.8984145}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.8172059}, {'id': 'https://openalex.org/C171056886', 'wikidata': 'https://www.wikidata.org/wiki/Q193119', 'display_name': 'Regeneration (biology)', 'level': 2, 'score': 0.7735959}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.6196145}, {'id': 'https://openalex.org/C3020332539', 'wikidata': 'https://www.wikidata.org/wiki/Q2014564', 'display_name': 'Articular cartilage', 'level': 4, 'score': 0.5590822}, {'id': 'https://openalex.org/C2779663596', 'wikidata': 'https://www.wikidata.org/wiki/Q2741512', 'display_name': 'Synovial joint', 'level': 5, 'score': 0.5072691}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4243258}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.32865927}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27739233}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.2764482}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.26608902}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.22836113}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002358', 'descriptor_name': 'Cartilage, Articular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002358', 'descriptor_name': 'Cartilage, Articular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002358', 'descriptor_name': 'Cartilage, Articular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D012038', 'descriptor_name': 'Regeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012038', 'descriptor_name': 'Regeneration', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D033581', 'descriptor_name': 'Stem Cell Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cbf.3246', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S960618578', 'display_name': 'Cell Biochemistry and Function', 'issn_l': '0263-6484', 'issn': ['0263-6484', '1099-0844'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/262779', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/bae7842f-1b57-488a-a141-7e782ab52e7c/download', 'source': {'id': 'https://openalex.org/S4306401777', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28083966', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/262779', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/bae7842f-1b57-488a-a141-7e782ab52e7c/download', 'source': {'id': 'https://openalex.org/S4306401777', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.5, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 127, 'referenced_works': ['https://openalex.org/W126539919', 'https://openalex.org/W1490404545', 'https://openalex.org/W1520384293', 'https://openalex.org/W1529276587', 'https://openalex.org/W1583565885', 'https://openalex.org/W162718904', 'https://openalex.org/W1688180349', 'https://openalex.org/W1764200940', 'https://openalex.org/W177397730', 'https://openalex.org/W1875416747', 'https://openalex.org/W1913334531', 'https://openalex.org/W192836234', 'https://openalex.org/W1941379021', 'https://openalex.org/W1963315781', 'https://openalex.org/W1967287827', 'https://openalex.org/W1968879356', 'https://openalex.org/W1969830786', 'https://openalex.org/W1973772276', 'https://openalex.org/W1974897852', 'https://openalex.org/W1980174191', 'https://openalex.org/W1980359398', 'https://openalex.org/W1983832419', 'https://openalex.org/W1985456809', 'https://openalex.org/W1985608961', 'https://openalex.org/W1985634042', 'https://openalex.org/W1985842679', 'https://openalex.org/W1986592776', 'https://openalex.org/W1988017079', 'https://openalex.org/W1988592246', 'https://openalex.org/W1991062831', 'https://openalex.org/W1991424506', 'https://openalex.org/W1993834457', 'https://openalex.org/W1994724005', 'https://openalex.org/W1995306753', 'https://openalex.org/W1999014699', 'https://openalex.org/W2000769193', 'https://openalex.org/W2001633027', 'https://openalex.org/W2001733207', 'https://openalex.org/W2002251686', 'https://openalex.org/W2003072177', 'https://openalex.org/W2003974937', 'https://openalex.org/W2004646124', 'https://openalex.org/W2009538670', 'https://openalex.org/W2009919278', 'https://openalex.org/W2011227409', 'https://openalex.org/W2011300682', 'https://openalex.org/W2013684315', 'https://openalex.org/W2015423555', 'https://openalex.org/W2017635145', 'https://openalex.org/W2017878971', 'https://openalex.org/W2018647053', 'https://openalex.org/W2019267756', 'https://openalex.org/W2020916353', 'https://openalex.org/W2025074364', 'https://openalex.org/W2025271177', 'https://openalex.org/W2026101620', 'https://openalex.org/W2028338364', 'https://openalex.org/W2028920679', 'https://openalex.org/W2035419502', 'https://openalex.org/W2036206658', 'https://openalex.org/W2040937120', 'https://openalex.org/W2041172383', 'https://openalex.org/W2042560195', 'https://openalex.org/W2047052363', 'https://openalex.org/W2048787681', 'https://openalex.org/W2050105202', 'https://openalex.org/W2050831894', 'https://openalex.org/W2051733637', 'https://openalex.org/W2053200644', 'https://openalex.org/W2056510698', 'https://openalex.org/W2057815348', 'https://openalex.org/W2060951121', 'https://openalex.org/W2062266932', 'https://openalex.org/W2062968651', 'https://openalex.org/W2063090620', 'https://openalex.org/W2064815984', 'https://openalex.org/W2064987181', 'https://openalex.org/W2069096538', 'https://openalex.org/W2070267630', 'https://openalex.org/W2070435400', 'https://openalex.org/W2071359561', 'https://openalex.org/W2071718640', 'https://openalex.org/W2073940027', 'https://openalex.org/W2076642520', 'https://openalex.org/W2076747902', 'https://openalex.org/W2079010022', 'https://openalex.org/W2082286201', 'https://openalex.org/W2082379059', 'https://openalex.org/W2088657142', 'https://openalex.org/W2089293788', 'https://openalex.org/W2092892410', 'https://openalex.org/W2093072634', 'https://openalex.org/W2094379754', 'https://openalex.org/W2094516299', 'https://openalex.org/W2095436179', 'https://openalex.org/W2098375711', 'https://openalex.org/W2100112117', 'https://openalex.org/W2102343281', 'https://openalex.org/W2104653602', 'https://openalex.org/W2113358240', 'https://openalex.org/W2113457553', 'https://openalex.org/W2115269982', 'https://openalex.org/W2118927304', 'https://openalex.org/W2118934189', 'https://openalex.org/W2124572309', 'https://openalex.org/W2127174807', 'https://openalex.org/W2128358050', 'https://openalex.org/W2129083253', 'https://openalex.org/W2135084900', 'https://openalex.org/W2139656906', 'https://openalex.org/W2144268541', 'https://openalex.org/W2149341739', 'https://openalex.org/W2150461606', 'https://openalex.org/W2153343790', 'https://openalex.org/W2155264840', 'https://openalex.org/W2156637446', 'https://openalex.org/W2158622693', 'https://openalex.org/W2161915238', 'https://openalex.org/W2168740468', 'https://openalex.org/W2169290563', 'https://openalex.org/W2170384389', 'https://openalex.org/W2236789517', 'https://openalex.org/W2267453521', 'https://openalex.org/W2313491747', 'https://openalex.org/W2418441967', 'https://openalex.org/W2732412084', 'https://openalex.org/W2993782230'], 'related_works': ['https://openalex.org/W4249655935', 'https://openalex.org/W4211001634', 'https://openalex.org/W2993030513', 'https://openalex.org/W2609988931', 'https://openalex.org/W2470558688', 'https://openalex.org/W2379670596', 'https://openalex.org/W2354155665', 'https://openalex.org/W2326020785', 'https://openalex.org/W2080714511', 'https://openalex.org/W1992004273'], 'abstract_inverted_index': {'Osteoarthritis': [0], '(OA)': [1], 'is': [2, 18, 30, 43], 'one': [3], 'of': [4, 14, 28, 39, 49, 64, 71, 86, 92, 116], 'the': [5, 11, 26, 34, 57, 69, 84, 114], 'most': [6], 'common': [7], 'diseases,': [8], 'which': [9], 'affect': [10, 60], 'correct': [12], 'functionality': [13], 'synovial': [15], 'joints': [16], 'and': [17, 89, 95, 112], 'characterized': [19], 'by': [20], 'articular': [21, 40], 'cartilage': [22, 41, 61, 87], 'degradation.': [23, 62], 'Limitation': [24], 'in': [25], 'treatment': [27], 'OA': [29], 'mostly': [31], 'due': [32], 'to': [33, 55, 77, 102, 105], 'very': [35], 'limited': [36], 'regenerative': [37], 'characteristic': [38], 'once': [42], 'damaged.': [44], 'Small': [45], 'animal': [46, 97], 'models': [47, 98], 'are': [48, 99], 'particular': [50], 'importance': [51], 'for': [52, 82], 'mechanistic': [53], 'analysis': [54], 'understand': [56], 'processes': [58, 85], 'that': [59, 109], 'Combination': [63], 'joint': [65], 'injury': [66], 'techniques': [67], 'with': [68], 'use': [70], 'stem': [72, 93], 'cells': [73, 94], 'has': [74], 'been': [75], 'shown': [76], 'be': [78], 'an': [79], 'important': [80, 100], 'tool': [81], 'understanding': [83], 'degradation': [88], 'regeneration.': [90], 'Implementation': [91], 'small': [96], 'tools': [101], 'help': [103], 'researchers': [104], 'find': [106], 'a': [107], 'solution': [108], 'could': [110], 'ameliorate': [111], 'prevent': [113], 'symptoms': [115], 'OA.': [117]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2572123927', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-27T03:53:26.390620', 'created_date': '2017-01-26'}